Lineage for Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase

  1. Root: SCOP 1.71
  2. 617324Class e: Multi-domain proteins (alpha and beta) [56572] (48 folds)
  3. 617469Fold e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)
    contains a cluster of helices and an alpha+beta sandwich
  4. 617470Superfamily e.3.1: beta-lactamase/transpeptidase-like [56601] (2 families) (S)
  5. 617471Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase [56602] (13 proteins)

Proteins:

  1. 617472AMPC beta-Lactamase, class C [56618] (3 species)
    contains small alpha+beta subdomain inserted in the common fold
    1. 617473Species Citrobacter freundii [TaxId:546] [56619] (3 PDB entries)
    2. 617479Species Enterobacter cloacae, P99, cephalosporinase [TaxId:550] [56620] (8 PDB entries)
    3. 617490Species Escherichia coli, cephalosporinase [TaxId:562] [56621] (32 PDB entries)
  2. 617555beta-Lactamase, class A [56606] (15 species)
    1. 617556Species Bacillus licheniformis [TaxId:1402] [56612] (5 PDB entries)
    2. 617567Species Enterobacter cloacae, NMC-A carbapenemase [TaxId:550] [56613] (2 PDB entries)
    3. 617570Species Escherichia coli, TEM-1 [TaxId:562] [56607] (28 PDB entries)
    4. 617601Species Escherichia coli, TOHO-1 [TaxId:562] [56608] (5 PDB entries)
    5. 617607Species Klebsiella pneumoniae, SHV-1 [TaxId:573] [56609] (7 PDB entries)
      inhibited by tazobactam
    6. 617615Species Klebsiella pneumoniae, SHV-2 [TaxId:573] [90082] (1 PDB entry)
      almost identical sequence to SHV-1
    7. 617617Species Klebsiella pneumoniae, TEM52 [TaxId:573] [64473] (1 PDB entry)
    8. 617624Species Mycobacterium fortuitum [TaxId:1766] [56615] (1 PDB entry)
    9. 617626Species Proteus vulgaris [TaxId:585] [75596] (1 PDB entry)
    10. 617629Species Pseudomonas aeruginosa, PER-1 [TaxId:287] [56616] (1 PDB entry)
    11. 617631Species Pseudomonas aeruginosa, PSE-4 carbenicillinase [TaxId:287] [56610] (2 PDB entries)
    12. 617634Species Serratia marcescens, Sme-1 [TaxId:615] [56617] (1 PDB entry)
      imipenem-hydrolyzing
    13. 617637Species Staphylococcus aureus [TaxId:1280] [56611] (16 PDB entries)
    14. 617656Species Stenotrophomonas maltophilia, L2 [TaxId:40324] [103374] (2 PDB entries)
    15. 617661Species Streptomyces albus G [TaxId:1962] [56614] (1 PDB entry)
  3. 617663Class D beta-lactamase [56622] (4 species)
    1. 617664Species Escherichia coli, OXA-1 [TaxId:562] [82837] (1 PDB entry)
    2. 617667Species Pseudomonas aeruginosa, OXA-10 [TaxId:287] [56623] (12 PDB entries)
    3. 617706Species Pseudomonas aeruginosa, OXA-13 [TaxId:287] [64474] (3 PDB entries)
    4. 617713Species Salmonella typhimurium, OXA-2 [TaxId:90371] [90083] (1 PDB entry)
  4. 617716D,D-carboxypeptidase DacA, N-terminal domain [118181] (1 species)
  5. 617722D-ala carboxypeptidase/transpeptidase [56603] (2 species)
    1. 617723Species Streptomyces sp., K15 [TaxId:1931] [56604] (7 PDB entries)
    2. 617731Species Streptomyces sp., R61 [TaxId:1931] [56605] (14 PDB entries)
  6. 617746D-aminopeptidase, N-terminal domain [56626] (1 species)
  7. 617749Esterase EstB [69873] (1 species)
  8. 617755Pencillin binding protein 4 (PbpD), N-terminal domain [111287] (1 species)
  9. 617759Penicillin binding protein 2a (PBP2A), C-terminal domain [82838] (1 species)
  10. 617771Penicillin receptor BlaR, C-terminal domain [103375] (1 species)
    closely related to class D beta-lactamase
  11. 617774Penicillin-binding protein 2x (pbp-2x), transpeptidase domain [56624] (1 species)
  12. 617786Penicillin-binding protein 5, N-terminal domain [69875] (1 species)
  13. 617792Regulatory protein BlaR1 [111289] (1 species)

More info for Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase

Timeline for Family e.3.1.1: beta-Lactamase/D-ala carboxypeptidase: