- Root: SCOP 1.75
Class e: Multi-domain proteins (alpha and beta) [56572] (66 folds)

e.1: Serpins [56573] (1 superfamily)

*contains a cluster of helices and a beta-sandwich*e.2: Replication terminator protein (Tus) [56595] (1 superfamily)

*contains a cluster of helices and a beta-sandwich*e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily)

*contains a cluster of helices and an alpha+beta sandwich*e.5: Heme-dependent catalase-like [56633] (1 superfamily)

*contains an (8,10) beta-barrel and an all-alpha domain*e.6: Acyl-CoA dehydrogenase NM domain-like [56644] (1 superfamily)

*2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology*e.7: Carbohydrate phosphatase [56654] (1 superfamily)

*N-terminal domain is an alpha+beta, C-terminal domain is an alpha/beta with mixed beta-sheet*e.8: DNA/RNA polymerases [56671] (1 superfamily)

*divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members*e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily)

*4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8*e.11: Type II DNA topoisomerase [56718] (1 superfamily)

*4 domains: (1) toprim alpha/beta; (2) "winged helix"-like; (3) alpha+beta; (4) all-alpha*e.12: DNA topoisomerase IV, alpha subunit [56725] (1 superfamily)

*2 domains: (1) toprim alpha/beta; (2) "winged helix"-like*e.13: DNA primase core [56730] (1 superfamily)

*2 domains: (1) alpha+beta; (2) toprim alpha/beta*e.15: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1 superfamily)

*2 domains: alpha+beta and all-beta*e.17: D-aminoacid aminotransferase-like PLP-dependent enzymes [56751] (1 superfamily)

*2 domains: (1) alpha+beta: beta3-alpha2-beta2; (2) alpha/beta, a part of its mixed sheet forms barrel: n=6, S=8*e.18: HydB/Nqo4-like [56761] (1 superfamily)

*3 domains: (1) all-alpha; (2&3) alpha+beta*e.19: HydA/Nqo6-like [56769] (1 superfamily)

*2 domains: (1) alpa/beta; (2) Fe-S cluster-bound*e.22: Dehydroquinate synthase-like [56795] (1 superfamily)

*2 domains: (1) alpha/beta of a Rossmann-fold topology, binds NAD (2) multihelical array*e.23: Acetyl-CoA synthetase-like [56800] (1 superfamily)

*4 domains: (1&2) duplication: share the same alpha/beta fold; (3) beta-barrel; (4) alpha+beta*e.24: Ribosomal protein L1 [56807] (1 superfamily)

*2 domains: (1) alpha+beta; (2) alpha/beta (interrupts domain 1)*e.25: Sec1/munc18-like (SM) proteins [56814] (1 superfamily)

*3 domains: (1 and 2) alpha+beta; (3) mostly alpha, inserted in domain 2*e.26: Prismane protein-like [56820] (1 superfamily)

*3 domains: (1) spectrin repeat-like 3-helical bundle; (2 and 3) alpha/beta: Rossmann-fold topology*e.27: Upper collar protein gp10 (connector protein) [56825] (1 superfamily)

*2 domains: (1) alpha-helical bundle; (2) beta-barrel (n=5, S=8)*e.28: Reovirus inner layer core protein p3 [56830] (1 superfamily)

*large protein without apparent domain division; has a number of all-alpha regions and one all beta domain near the C-end*e.29: beta and beta-prime subunits of DNA dependent RNA-polymerase [64483] (1 superfamily)

*Multidomain subunits of complex domain organization*e.32: Phase 1 flagellin [64517] (1 superfamily)

*3 domains: (1) alpha-helical bundle; (2&3) complex all-beta folds*e.34: NSP3 homodimer [69902] (1 superfamily)

*2 domains: (1) all-alpha, (2) alpha+beta; asymmetric homodimer with each domain intertwining with its counterpart*e.35: Membrane penetration protein mu1 [69907] (1 superfamily)

*4 domains: three intertwined predominately alpha domains and one jelly-roll beta-sandwich*e.37: Siroheme synthase middle domains-like [75614] (1 superfamily)

*2 domains: (1) alpha+beta, 2 layers; (2) 3/4-helical bundle, right-handed twist, left-handed superhelix*e.38: Release factor [75619] (1 superfamily)

*4 domains: (1) 3-helical bundle; (2) alpha+beta of ferredoxin-like fold (3 and 4) alpha+beta of dsRDB-like fold*e.39: YebC-like [75624] (1 superfamily)

*3 domains: (1) 3-helical bundle; (2 and 3 ) alpha+beta of different folds: domain 3 has a ferredoxin-like fold and is inserted in domain 2*e.40: Cullin homology domain [75631] (1 superfamily)

*3 domains: (1) 4-helical bundle; (2) alpha+beta; (3) "winged helix"-like*e.41: Adenylylcyclase toxin (the edema factor) [81299] (1 superfamily)

*3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha*e.42: L-A virus major coat protein [82855] (1 superfamily)

*large protein without apparent domain division*e.43: Subunits of heterodimeric actin filament capping protein Capz [90095] (1 superfamily)

*3 domains: (1) protozoan pheromone-like alpha-helical bundle; (2) rubredoxin-like domain lacking metal-binding site; (3) alpha+beta heterodimerisation domain: alpha-beta(5)-alpha*e.44: 2-methylcitrate dehydratase PrpD [103377] (1 superfamily)

*consists of an all-alpha and alpha+beta domains*e.45: Antivirulence factor [103382] (1 superfamily)

*contains a helical bundle with a buried helix and an alpha+beta insert domain*e.46: Virulence-associated V antigen [103387] (1 superfamily)

*consists of an all-alpha and alpha+beta domains connected by antiparallel coiled coil*e.47: 39 kda initiator binding protein, IBP39, C-terminal domains [103408] (1 superfamily)

*2 closely associated domains: (1) all-alpha, EF-hand like; (2) alpha+beta, Frataxin-like*e.48: Major capsid protein VP5 [103416] (1 superfamily)

*large protein without apparent domain division*e.49: Recombination protein RecR [111303] (1 superfamily)

*consists of three domains: alpha-helical dimerisation domain (res. 1-53) with HhH motif; 'treble cleft' C4 zinc-finger domain (54-76); and Toprim domain (76-199; segment-swapped dimer)*e.50: AF1104-like [111320] (1 superfamily)

*2 domains; d1: [all-alpha; 3-helical bundle, similar to the immunoglobulin/albumin-binding domain-like fold ((46996))]; d2: [alpha/beta; 3 layers, a/b/a; 6-stranded mixed beta-sheet, order: 321456, strand 6 is antiparallel to the rest]*

2 domains; d1: [all-alpha; 3-helical bundle, similar to the immunoglobulin/albumin-binding domain-like fold ((46996))]; d2: [alpha/beta; 3 layers, a/b/a; 6-stranded mixed beta-sheet, order: 321456, strand 6 is antiparallel to the rest]e.51: Urocanase [111325] (1 superfamily)

*3 domains; d1: alpha+beta [alpha(2)-beta(3); mixed sheet: 213]; d2: alpha/beta of the NAD(P)-binding Rossmann-fold superfamily ((51735), most similar to (51883) and (51736)); d3: alpha+beta of the glutamine synthetase/guanido kinase fold ((55930)); d1 and d3 form a single beta-sheet*

3 domains; d1: alpha+beta [alpha(2)-beta(3); mixed sheet: 213]; d2: alpha/beta of the NAD(P)-binding Rossmann-fold superfamily ((51735), most similar to (51883) and (51736)); d3: alpha+beta of the glutamine synthetase/guanido kinase fold (55930)); d1 and d3 form a single beta-sheete.52: NAD kinase/diacylglycerol kinase-like [111330] (1 superfamily)

*2 domains: d1 [alpha/beta; related to the PFK N-terminal domain ((53784))]; d2 [all-beta; atypical beta-sandwich made of 4 structural repeats of beta(3) unit]*

2 domains: d1 [alpha/beta; related to the PFK N-terminal domain ((53784))]; d2 [all-beta; atypical beta-sandwich made of 4 structural repeats of beta(3) unit]e.53: QueA-like [111336] (1 superfamily)

*2 domains; d1 (1-64,174-335) [alpha/beta; 3 layers, a/b/a; mixed beta sheet of 9 strands, order: 219863457; strands 1, 5 and 8 are antiparallel to the rest]; d2 (65-142) [all-beta; barrel, closed (n=6, S=10); greek-key; topologically similar to the split barrel fold ((50474))*

2 domains; d1 (1-64,174-335) [alpha/beta; 3 layers, a/b/a; mixed beta sheet of 9 strands, order: 219863457; strands 1, 5 and 8 are antiparallel to the rest]; d2 (65-142) [all-beta; barrel, closed (n=6, S=10); greek-key; topologically similar to the split barrel fold ((50474))e.54: CbiD-like [111341] (1 superfamily)

*2 domains; (1) alpha+beta (res 1-192), a circularly permuted rS5 domain 2-like fold ((54210)); (2) alpha/beta with parallel beta-sheet of 4 strands, order 2134*

2 domains; (1) alpha+beta (res 1-192), a circularly permuted rS5 domain 2-like fold ((54210)); (2) alpha/beta with parallel beta-sheet of 4 strands, order 2134e.55: Rap/Ran-GAP [111346] (1 superfamily)

*consists of two domains; d1: alpha+beta (78-190; alpha-beta(4)-alpha-beta-alpha; 3 layers; antiparallel beta-sheet of 5 strands; order 51234); d2: alpha/beta similar to the G-domain fold (191-381; (52592))*

consists of two domains; d1: alpha+beta (78-190; alpha-beta(4)-alpha-beta-alpha; 3 layers; antiparallel beta-sheet of 5 strands; order 51234); d2: alpha/beta similar to the G-domain fold (191-381; (52592))e.56: YaeB-like [118195] (1 superfamily)

*2 domains; d1: [beta-barrel (n=6, S=10), similar to the Reductase/isomerase/elongation factor common domain fold ((50412)), provides homodimerisation interface]; d2: [alpha+beta (disordered)]*

2 domains; d1: [beta-barrel (n=6, S=10), similar to the Reductase/isomerase/elongation factor common domain fold ((50412)), provides homodimerisation interface]; d2: [alpha+beta (disordered)]e.57: Vacuolar ATP synthase subunit C [118202] (1 superfamily)

*2 alpha+beta (sub)domains [each has a ferredoxin-like fold; (54861)], connected with 3-helical bundle; duplication: two repeats of beta-alpha-beta-[alpha coiled-coil]-beta-alpha-beta motif*

2 alpha+beta (sub)domains [each has a ferredoxin-like fold; (54861)], connected with 3-helical bundle; duplication: two repeats of beta-alpha-beta-[alpha coiled-coil]-beta-alpha-beta motife.58: Viral ssDNA binding protein [118207] (1 superfamily)

*2 domains; d1: [large alpha+beta domain subdivided into the 'head', 'neck' and 'shoulders' regions; in the 'neck', there is an OB-fold interrupted by large insertions]; d2: [all-alpha, 6 helices; orthogonal array]*e.59: FdhE-like [144019] (1 superfamily)

*consists on the N-terminal five-helical bundle, a tandem repeat of two rubredoxin-like domains and the C-terminal helix packed together*e.60: Thermophilic metalloprotease-like [144051] (1 superfamily)

*consists of two domains; d1: alpha/beta (3 layers, a/b/a; parralel beta-sheet, order 2134); d2: pseudo beta-barrel capped by helices*e.61: ImpE-like [144058] (1 superfamily)

*consists of two domains; d1: right-handed superhelix of five helices; d2: pseudo beta-barrel containing structurally similar part to the "Histone-like" proteins from archaea ((54161))*

consists of two domains; d1: right-handed superhelix of five helices; d2: pseudo beta-barrel containing structurally similar part to the "Histone-like" proteins from archaea ((54161))e.62: Heme iron utilization protein-like [144063] (1 superfamily)

*2 domains; d1 - 3-helical bundle similar to the homeodomain-like fold; d2 - 6-stranded beta-barrel capped by two helices at one end, similar topology to the PH-like fold*e.63: E2F-DP heterodimerization region [144073] (1 superfamily)

*heterodimeric fold with the N-terminal long helices of both chains forming a parallel coiled coil and their C-terminal folded beta-hairpins interlocking together in a beta-sandwich*e.64: FlhC-like [160929] (1 superfamily)

*3 domains; d1 & d2 are similar three-helical bundles, with d1 containing an HTH motif; d3: zinc finger of a rubredoxin-like fold*e.65: VPA0735-like [160934] (1 superfamily)

*consists of a cluster of helices and two beta-sandwich domains of similar topology; probable duplication*e.66: Api92-like [160939] (1 superfamily)

*2 domains; d1: [alpha+beta with similarity to ferredoxin-like fold]; d2: [6 helices, bundle, one buried central helix], inserted into d1*e.67: PH0156-like [160944] (1 superfamily)

*2 (sub)domains; d1: [alpha/beta with central mixed beta-sheet, order: 23415876, similarity to the G protein but no P-loop]; d2: [all-alpha, 5 helices, provides dimerization interface]*e.68: YacF-like [160949] (1 superfamily)

*2 domains; d1: kinked four-helical bundle, inserted in d2: beta-sandwich of 7 strands in two sheets*e.69: Poly(A) polymerase catalytic subunit-like [160956] (1 superfamily)

*3 domains; d1: all-alpha, contains HhH motif; d2: alpha+beta of nucleotidyltransferase fold ((81302)); d3: [alpha+beta; beta(3)-alpha-beta(3)-alpha(2); 3 layers: a/b/a; mixed beta-sheet of 6 strands, order 123654, strands 2 and 5 are antiparallel to the rest*

3 domains; d1: all-alpha, contains HhH motif; d2: alpha+beta of nucleotidyltransferase fold ((81302)); d3: [alpha+beta; beta(3)-alpha-beta(3)-alpha(2); 3 layers: a/b/a; mixed beta-sheet of 6 strands, order 123654, strands 2 and 5 are antiparallel to the reste.70: MalF N-terminal region-like [160963] (1 superfamily)

*consists of 3 N-terminal transmembrane helices, an alpha+beta linker domain and a beta-barrel (n=7; S=8) with one overside loop*e.71: AF1531-like [160974] (1 superfamily)

*2 domains; d1: incomplete barrel similar to the OB-fold domain of ribosomal L2 protein, d2: six helices, array*e.72: SSO1389-like [160979] (1 superfamily)

*2 domains; d1: [alpha/beta, central parallel beta-sheet of 6 strands, order 321456, Rossmann-like]; d2: [alpha+beta, cluster of helices and a small 4-stranded beta-sheet]*e.73: CV3147-like [160990] (1 superfamily)

*2 domains; d1: [alpha/beta; 3 layers, a/b/a, mixed beta-sheet of 8 strands, order 12543876, strands 1, 7 and 8 are antiparallel to the rest]; d2: [pseudo beta-barrel of 6 strands, meander]*e.74: HI0933 insert domain-like [160995] (1 superfamily)

*2 domains; d1: barrel, closed, n=6, S=12, greek-key; d2: four-helical bundle, inserted in d1*e.75: Flu NP-like [161002] (1 superfamily)

*consists of alpha+beta and all-alpha domains; biological unit is a trimer*e.76: Viral glycoprotein ectodomain-like [161007] (1 superfamily)

*complex fold; contains three rigid, mostly-beta domains and an alpha-helical region, acting as a conformatiomal switch ("fusion stalk")*

**Timeline for Class e: Multi-domain proteins (alpha and beta)**:

- Class e: Multi-domain proteins (alpha and beta) first appeared (with stable ids) in SCOP 1.55

- Class e: Multi-domain proteins (alpha and beta) appears in SCOP 1.73

- Class e: Multi-domain proteins (alpha and beta) appears in SCOPe 2.01

- Class e: Multi-domain proteins (alpha and beta) appears in the current release, SCOPe 2.08