Folds:

1. e.1: Serpins [56573] (1 superfamily) contains a cluster of helices and a beta-sandwich

2. e.2: Replication terminator protein (Tus) [56595] (1 superfamily) contains a cluster of helices and a beta-sandwich

3. e.3: beta-lactamase/transpeptidase-like [56600] (1 superfamily) contains a cluster of helices and an alpha+beta sandwich

4. e.4: ADP ribosyl cyclase-like [56628] (1 superfamily) contains a cluster of helices and an alpha/beta domain

5. e.5: Heme-dependent catalases [56633] (1 superfamily) contains an (8,10) beta-barrel and an all-alpha domain

6. e.6: Acyl-CoA dehydrogenase NM domain-like [56644] (1 superfamily) 2 domains: (1) all-alpha: 5 helices; (2) contains an open beta-sheet barrel: n*=5, S*=8; complex topology

7. e.7: Carbohydrate phosphatase [56654] (1 superfamily) N-terminal domain is an alpha+beta, C-terminal domain is an alpha/beta with mixed beta-sheet

8. e.8: DNA/RNA polymerases [56671] (1 superfamily) divided into morphological domains including "palm", "thumb" and "fingers"; the catalytic "palm" domain is conserved to all members

9. e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily) 4 domains: (1) Toprim alpha/beta; (2&4) "winged helix"-like; (3) barrel: n=6, S=8

10. e.11: Type II DNA topoisomerase [56718] (1 superfamily) 4 domains: (1) toprim alpha/beta; (2) "winged helix"-like; (3) alpha+beta; (4) all-alpha

11. e.12: DNA topoisomerase IV, alpha subunit [56725] (1 superfamily) 2 domains: (1) toprim alpha/beta; (2) "winged helix"-like

12. e.13: DNA primase core [56730] (1 superfamily) 2 domains: (1) alpha+beta; (2) toprim alpha/beta

13. e.15: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1 superfamily) 2 domains: alpha+beta and all-beta

14. e.17: D-aminoacid aminotransferase-like PLP-dependent enzymes [56751] (1 superfamily) 2 domains: (1) alpha+beta: beta3-alpha2-beta2; (2) alpha/beta, a part of its mixed sheet forms barrel: n=6, S=8

15. e.18: Nickel-iron hydrogenase, large subunit [56761] (1 superfamily) 3 domains: (1) all-alpha; (2&3) alpha+beta

16. e.19: Nickel-iron hydrogenase, small subunit [56769] (1 superfamily) 2 domains: (1) alpa/beta; (2) Fe-S cluster-bound

17. e.22: Dehydroquinate synthase-like [56795] (1 superfamily) 2 domains: (1) alpha/beta of a Rossmann-fold topology, binds NAD (2) multihelical array

18. e.23: Acetyl-CoA synthetase-like [56800] (1 superfamily) 4 domains: (1&2) duplication: share the same alpha/beta fold; (3) beta-barrel; (4) alpha+beta

19. e.24: Ribosomal protein L1 [56807] (1 superfamily) 2 domains: (1) alpha+beta; (2) alpha/beta (interrupts domain 1)

20. e.25: Sec1/munc18-like (SM) proteins [56814] (1 superfamily) 3 domains: (1 and 2) alpha+beta; (3) mostly alpha, inserted in domain 2

21. e.26: Prismane protein-like [56820] (1 superfamily) 3 domains: (1) spectrin repeat-like 3-helical bundle; (2 and 3) alpha/beta: Rossmann-fold topology

22. e.27: Upper collar protein gp10 (connector protein) [56825] (1 superfamily) 2 domains: (1) alpha-helical bundle; (2) beta-barrel (n=5, S=8)

23. e.28: Reovirus inner layer core protein p3 [56830] (1 superfamily) large protein without apparent domain division; has a number of all-alpha regions and one all beta domain near the C-end

24. e.29: beta and beta-prime subunits of DNA dependent RNA-polymerase [64483] (1 superfamily) Multidomain subunits of complex domain organization

25. e.30: DNA-binding domain of intron endonuclease I-TevI [64495] (1 superfamily) extended structure wrapping around DNA; contains a zinc finger, a minor groove-binding helix and an alpha+beta domain with an HTH motif

26. e.32: Phase 1 flagellin [64517] (1 superfamily) 3 domains: (1) alpha-helical bundle; (2&3) complex all-beta folds

27. e.34: NSP3 homodimer [69902] (1 superfamily) 2 domains: (1) all-alpha, (2) alpha+beta; asymmetric homodimer with each domain intertwining with its counterpart

28. e.35: Membrane penetration protein mu1 [69907] (1 superfamily) 4 domains: three intertwined predominately alpha domains and one jelly-roll beta-sandwich

29. e.37: Siroheme synthase middle domains-like [75614] (1 superfamily) 2 domains: (1) alpha+beta, 2 layers; (2) 3/4-helical bundle, right-handed twist, left-handed superhelix

30. e.38: Polypeptide chain release factor 2 (RF2) [75619] (1 superfamily) 4 domains: (1) 3-helical bundle; (2) alpha+beta of ferredoxin-like fold (3 and 4) alpha+beta of dsRDB-like fold

31. e.39: YebC-like [75624] (1 superfamily) 3 domains: (1) 3-helical bundle; (2 and 3 ) alpha+beta of different folds: domain 3 has a ferredoxin-like fold and is inserted in domain 2

32. e.40: Cullin homology domain [75631] (1 superfamily) 3 domains: (1) 4-helical bundle; (2) alpha+beta; (3) "winged helix"-like

33. e.41: Adenylylcyclase toxin (the edema factor) [81299] (1 superfamily) 3 domains: (1&2) alpha+beta, with domain 2 being inserted in domain 1; (3) all-alpha

34. e.42: L-A virus major coat protein [82855] (1 superfamily) large protein without apparent domain division

35. e.43: Subunits of heterodimeric actin filament capping protein Capz [90095] (1 superfamily) 3 domains: (1) protozoan pheromone-like alpha-helical bundle; (2) rubredoxin-like domain lacking metal-binding site; (3) alpha+beta heterodimerisation domain: alpha-beta(5)-alpha

36. e.44: 2-methylcitrate dehydratase PrpD [103377] (1 superfamily) consists of an all-alpha and alpha+beta domains

37. e.45: Antivirulence factor [103382] (1 superfamily) contains a helical bundle with a buried helix and an alpha+beta insert domain

38. e.46: Virulence-associated V antigen [103387] (1 superfamily) consists of an all-alpha and alpha+beta domains connected by antiparallel coiled coil

39. e.47: 39 kda initiator binding protein, IBP39, C-terminal domains [103408] (1 superfamily) 2 closely associated domains: (1) all-alpha, EF-hand like; (2) alpha+beta, Frataxin-like

40. e.48: Major capsid protein VP5 [103416] (1 superfamily) large protein without apparent domain division

More info for Class e: Multi-domain proteins (alpha and beta)

Timeline for Class e: Multi-domain proteins (alpha and beta):

• Class e: Multi-domain proteins (alpha and beta) first appeared (with stable ids) in SCOP 1.55
  
• Class e: Multi-domain proteins (alpha and beta) appears in SCOP 1.65
  
• Class e: Multi-domain proteins (alpha and beta) appears in SCOP 1.69
  
• Class e: Multi-domain proteins (alpha and beta) appears in the current release, SCOPe 2.08