SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Class e: Multi-domain proteins (alpha and beta)

  1. Root: SCOP 1.55
  2. 37754Class e: Multi-domain proteins (alpha and beta) [56572] (28 folds)

Folds:

  1. 37755e.1: Serpins [56573] (1 superfamily)
  2. 37837e.2: Replication terminator protein (Tus) [56595] (1 superfamily)
  3. 37843e.3: beta-Lactamase/D-ala carboxypeptidase [56600] (1 superfamily)
  4. 37965e.4: ADP ribosyl cyclase [56628] (1 superfamily)
  5. 37972e.5: Heme-linked catalases [56633] (1 superfamily)
  6. 38059e.6: Acyl-CoA dehydrogenase (flavoprotein), N-terminal and middle domains [56644] (1 superfamily)
  7. 38091e.7: Sugar phosphatases [56654] (1 superfamily)
  8. 38209e.8: DNA/RNA polymerases [56671] (1 superfamily)
  9. 38384e.9: Nucleotidyltransferases [56698] (1 superfamily)
  10. 38511e.10: Prokaryotic type I DNA topoisomerase [56711] (1 superfamily)
  11. 38531e.11: Type II DNA topoisomerase [56718] (1 superfamily)
  12. 38541e.12: DNA topoisomerase IV, alpha subunit [56725] (1 superfamily)
  13. 38548e.13: DNA primase DnaG catalytic core [56730] (1 superfamily)
  14. 38560e.14: DNA repair protein MutM (Fpg) [56735] (1 superfamily)
  15. 38567e.15: Eukaryotic DNA topoisomerase I, N-terminal DNA-binding fragment [56740] (1 superfamily)
  16. 38578e.16: DNA primase [56746] (1 superfamily)
  17. 38585e.17: D-amino acid aminotransferase-like PLP-dependent enzymes [56751] (1 superfamily)
  18. e.18: Nickel-iron hydrogenase, large subunit [56761] (1 superfamily)
  19. e.19: Nickel-iron hydrogenase, small subunit [56769] (1 superfamily)
  20. 38655e.20: Heat shock protein 70kD (HSP70), C-terminal, substrate-binding fragment [56777] (1 superfamily)
  21. 38670e.21: HAD-like [56783] (1 superfamily)
  22. 38706e.22: Dehydroquinate synthase, DHQS [56795] (1 superfamily)
  23. 38713e.23: Firefly luciferase-like [56800] (1 superfamily)
  24. 38724e.24: Ribosomal protein L1 [56807] (1 superfamily)
  25. 38735e.25: Neuronal Sec1, NSec1 [56814] (1 superfamily)
  26. 38746e.26: Hybrid cluster protein (prismane protein) [56820] (1 superfamily)
  27. 38753e.27: Upper collar protein gp10 (connector protein) [56825] (1 superfamily)
  28. 38770e.28: BTV inner layer core protein vp3 [56830] (1 superfamily)

More info for Class e: Multi-domain proteins (alpha and beta)

Timeline for Class e: Multi-domain proteins (alpha and beta):