SCOP 1.71: Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

Lineage for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.162: LDH C-terminal domain-like [56326] (1 superfamily)
   unusual fold, defines family

4. Superfamily d.162.1: LDH C-terminal domain-like [56327] (2 families)

5. Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain [56328] (4 proteins)
   N-terminal domain is NAD-binding module (alpha/beta Rossmann-fold domain)

Proteins:

1. L-2-hydroxyisocapronate dehydrogenase, L-HICDH [56337] (1 species)

   • Species Lactobacillus confusus [TaxId:1583] [56338] (1 PDB entry)

2. Lactate dehydrogenase [56339] (15 species)

   1. Species Archaeon Archaeoglobus fulgidus [TaxId:2234] [111253] (2 PDB entries)

   2. Species Bacillus stearothermophilus [TaxId:1422] [56344] (3 PDB entries)

   3. Species Bifidobacterium longum, strain am101-2 [TaxId:216816] [56346] (2 PDB entries)

   4. Species Clostridium thermocellum [TaxId:1515] [118160] (1 PDB entry)

   5. Species Dogfish (Squalus acanthias) [TaxId:7797] [56342] (3 PDB entries)

   6. Species Human (Homo sapiens), heart isoform (H chain) [TaxId:9606] [64444] (2 PDB entries)

   7. Species Human (Homo sapiens), muscle isoform (M chain) [TaxId:9606] [64445] (1 PDB entry)

   8. Species Lactobacillus casei [TaxId:1582] [56345] (1 PDB entry)

   9. Species Lactobacillus pentosus [TaxId:1589] [69843] (1 PDB entry)

   10. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [56343] (9 PDB entries)

   11. Species Mouse (Mus musculus) [TaxId:10090] [56341] (1 PDB entry)

   12. Species Pig (Sus scrofa) [TaxId:9823] [56340] (3 PDB entries)

   13. Species Plasmodium berghei [103325] (1 PDB entry)

   14. Species Thermotoga maritima [TaxId:243274] [56347] (1 PDB entry)

   15. Species Toxoplasma gondii [TaxId:5811] [103326] (4 PDB entries)

3. Malate dehydrogenase [56329] (11 species)

   1. Species Aquaspirillum arcticum [TaxId:87645] [56336] (3 PDB entries)

   2. Species Archaeon Haloarcula marismortui [TaxId:2238] [56335] (5 PDB entries)

   3. Species Chlorobium tepidum [TaxId:1097] [69841] (1 PDB entry)

   4. Species Chlorobium vibrioforme [TaxId:1098] [69842] (2 PDB entries)

   5. Species Chloroflexus aurantiacus [69840] (7 PDB entries)

   6. Species Escherichia coli [TaxId:562] [56333] (4 PDB entries)

   7. Species Flaveria bidentis, chloroplast [TaxId:4224] [56332] (1 PDB entry)

   8. Species Pig (Sus scrofa) [TaxId:9823] [56330] (3 PDB entries)

   9. Species Sorghum (Sorghum vulgare), chloroplast [TaxId:4558] [56331] (1 PDB entry)

   10. Species Thermus flavus [TaxId:274] [56334] (2 PDB entries)

   11. Species Thermus thermophilus [TaxId:274] [82806] (1 PDB entry)
       identical sequence to that from the Thermus flavus enzyme

4. MJ0490, lactate/malate dehydrogenase [64446] (1 species)

   • Species Archaeon Methanococcus jannaschii [TaxId:2190] [64447] (2 PDB entries)

More info for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain

Timeline for Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain:

• Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain first appeared (with stable ids) in SCOP 1.55
  
• Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in SCOP 1.69
  
• Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in SCOP 1.73
  
• Family d.162.1.1: Lactate & malate dehydrogenases, C-terminal domain appears in the current release, SCOPe 2.08