Lineage for Protein: Glycosylasparaginase (aspartylglucosaminidase, AGA)

  1. Root: SCOP 1.75
  2. 849709Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 875596Fold d.153: Ntn hydrolase-like [56234] (2 superfamilies)
    4 layers: alpha/beta/beta/alpha; has an unusual sheet-to-sheet packing
  4. 875597Superfamily d.153.1: N-terminal nucleophile aminohydrolases (Ntn hydrolases) [56235] (7 families) (S)
    N-terminal residue provides two catalytic groups, nucleophile and proton donor
  5. 876412Family d.153.1.5: (Glycosyl)asparaginase [56261] (1 protein)
  6. 876413Protein Glycosylasparaginase (aspartylglucosaminidase, AGA) [56262] (3 species)
    the precursor chain is cleaved onto 2 fragments by autoproteolysis

Species:

  1. 876414Escherichia coli [TaxId:562] [103315] (3 PDB entries)
    Uniprot P37595
    isoaspartyl peptidase with L-asparaginase activity
    putative L-asparaginase YbiK
    1. Domains for 1jn9:
      1. 876419Domain d1jn9.1: 1jn9 A:,B: [90898]
      2. 876420Domain d1jn9.2: 1jn9 C:,D: [90899]
        complexed with ca, cl, na
    2. Domains for 1k2x:
      1. 876415Domain d1k2x.1: 1k2x A:,B: [90929]
      2. 876416Domain d1k2x.2: 1k2x C:,D: [90930]
        complexed with cl, na
    3. Domains for 1t3m:
      1. 876417Domain d1t3m.1: 1t3m A:,B: [106361]
      2. 876418Domain d1t3m.2: 1t3m C:,D: [106362]
        complexed with na, no3
  2. 876421Flavobacterium meningosepticum [TaxId:238] [56264] (8 PDB entries)
    1. Domains for 1ayy:
      1. 876426Domain d1ayy.1: 1ayy A:,B: [42016]
      2. 876427Domain d1ayy.2: 1ayy C:,D: [42017]
    2. Domains for 1p4k:
      1. 876428Domain d1p4ka_: 1p4k A: [87772]
        precursor D151N mutant
      2. 876429Domain d1p4kc_: 1p4k C: [87773]
        precursor D151N mutant
    3. Domains for 1p4v:
      1. 876432Domain d1p4va_: 1p4v A: [87781]
        precursor D151N mutant
      2. 876433Domain d1p4vc_: 1p4v C: [87782]
        precursor D151N mutant
    4. Domains for 2gac:
      1. 876422Domain d2gac.1: 2gac A:,B: [42012]
      2. 876423Domain d2gac.2: 2gac C:,D: [42013]
        mutant
    5. Domains for 2gaw:
      1. 876424Domain d2gaw.1: 2gaw A:,B: [42018]
      2. 876425Domain d2gaw.2: 2gaw C:,D: [42019]
    6. Domains for 9gaa:
      1. 876436Domain d9gaaa_: 9gaa A: [42014]
        Precursor T152A mutant
      2. 876437Domain d9gaac_: 9gaa C: [42015]
        Precursor T152A mutant
    7. Domains for 9gac:
      1. 876434Domain d9gaca_: 9gac A: [42010]
        Precursor of the T152C mutant
      2. 876435Domain d9gacc_: 9gac C: [42011]
        Precursor of the T152C mutant
    8. Domains for 9gaf:
      1. 876430Domain d9gafa_: 9gaf A: [42008]
        Precursor W11F mutant
      2. 876431Domain d9gafc_: 9gaf C: [42009]
        Precursor W11F mutant
  3. 876438Human (Homo sapiens) [TaxId:9606] [56263] (2 PDB entries)
    1. Domains for 1apy:
      1. 876439Domain d1apy.1: 1apy A:,B: [42004]
      2. 876440Domain d1apy.2: 1apy C:,D: [42005]
        complexed with man, nag
    2. Domains for 1apz:
      1. 876441Domain d1apz.1: 1apz A:,B: [42006]
      2. 876442Domain d1apz.2: 1apz C:,D: [42007]
        complexed with man, nag

More info for Protein Glycosylasparaginase (aspartylglucosaminidase, AGA) from d.153.1.5: (Glycosyl)asparaginase

Timeline for Protein Glycosylasparaginase (aspartylglucosaminidase, AGA) from d.153.1.5: (Glycosyl)asparaginase: