SCOPe 2.01: Family d.148.1.1: Hect, E3 ligase catalytic domain

Lineage for Family d.148.1.1: Hect, E3 ligase catalytic domain

1. Root: SCOPe 2.01

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.148: Hect, E3 ligase catalytic domain [56203] (1 superfamily)
   consists of two alpha+beta domains; the N-terminal domain is array of helices and beta-hairpins; the C-terminal domain is an a/b sandwich with one left-handed beta-alpha(n)-beta unit; conformational flexibility of domain orientation

4. Superfamily d.148.1: Hect, E3 ligase catalytic domain [56204] (1 family)

5. Family d.148.1.1: Hect, E3 ligase catalytic domain [56205] (2 proteins)

Proteins:

1. Ubiquitin-protein ligase E3a (E6ap) [56206] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [56207] (2 PDB entries)

2. WW domain-containing protein 1, WWP1 [103308] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [103309] (1 PDB entry)

More info for Family d.148.1.1: Hect, E3 ligase catalytic domain

Timeline for Family d.148.1.1: Hect, E3 ligase catalytic domain:

• Family d.148.1.1: Hect, E3 ligase catalytic domain first appeared (with stable ids) in SCOP 1.55, called Family d.148.1.1: Ubiquitin-protein ligase E3a, Hect catalytic domain (E6ap)
  
• Family d.148.1.1: Hect, E3 ligase catalytic domain appears in SCOP 1.75
  
• Family d.148.1.1: Hect, E3 ligase catalytic domain appears in SCOPe 2.02
  
• Family d.148.1.1: Hect, E3 ligase catalytic domain appears in the current release, SCOPe 2.08