SCOPe Funding Alert: SCOPe support from the NIH ended in April 2016. John-Marc Chandonia is the primary maintainer and has continued to develop SCOPe using vacation time. Three proposals to the NIH for continued funding have been unsuccessful. If our current NIH proposal is not funded, SCOPe will shut down permanently in Summer 2017 as Dr. Chandonia will need to seek a new position.

Lineage for Superfamily d.144.1: Protein kinase-like (PK-like)

  1. Root: SCOPe 2.06
  2. 2152203Class d: Alpha and beta proteins (a+b) [53931] (385 folds)
  3. 2195565Fold d.144: Protein kinase-like (PK-like) [56111] (1 superfamily)
    consists of two alpha+beta domains, C-terminal domain is mostly alpha helical
  4. 2195566Superfamily d.144.1: Protein kinase-like (PK-like) [56112] (8 families) (S)
    shares functional and structural similarities with the ATP-grasp fold and PIPK


  1. 2195567d.144.1.3: Actin-fragmin kinase, catalytic domain [56168] (1 protein)
    Atypical protein kinases
  2. 2195572d.144.1.4: Phoshoinositide 3-kinase (PI3K), catalytic domain [56171] (1 protein)
  3. 2195640d.144.1.5: MHCK/EF2 kinase [64408] (1 protein)
    Atypical protein kinases
  4. 2195649d.144.1.6: APH phosphotransferases [64411] (5 protein domains)
  5. 2195690d.144.1.7: Protein kinases, catalytic subunit [88854] (66 protein domains)
    members organized in the groups and subfamiles specified by the comments
  6. 2199053d.144.1.8: Choline kinase [90040] (2 protein domains)
    Pfam PF02958
  7. 2199092d.144.1.9: RIO1-like kinases [111204] (1 protein)
    Pfam PF01163
  8. 2199100d.144.1.0: automated matches [191359] (1 protein)
    not a true family

More info for Superfamily d.144.1: Protein kinase-like (PK-like)

Timeline for Superfamily d.144.1: Protein kinase-like (PK-like):