Lineage for Protein: Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain

  1. Root: SCOPe 2.01
  2. 1013083Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1038908Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 1038909Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (1 family) (S)
  5. 1038910Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)
  6. 1038911Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

Species:

  1. 1038912Cryptosporidium hominis [TaxId:237895] [100887] (4 PDB entries)
    1. Domains for 1j3j:
      1. 1038913Domain d1j3jc_: 1j3j C: [84068]
        Other proteins in same PDB: d1j3ja_, d1j3jb_
        complexed with cp6, ndp, ump; mutant
      2. 1038914Domain d1j3jd_: 1j3j D: [84069]
        Other proteins in same PDB: d1j3ja_, d1j3jb_
        complexed with cp6, ndp, ump; mutant
    2. Domains for 1qzf:
      1. 1038920Domain d1qzfa2: 1qzf A:181-521 [96634]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
      2. 1038921Domain d1qzfb2: 1qzf B:181-521 [96636]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
      3. 1038922Domain d1qzfc2: 1qzf C:181-521 [96638]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
      4. 1038923Domain d1qzfd2: 1qzf D:181-521 [96640]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
      5. 1038924Domain d1qzfe2: 1qzf E:181-521 [96642]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
    3. Domains for 1sej:
      1. 1038925Domain d1seja2: 1sej A:233-521 [105456]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
      2. 1038926Domain d1sejb2: 1sej B:233-521 [105458]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
      3. 1038927Domain d1sejc2: 1sej C:233-521 [105460]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
      4. 1038928Domain d1sejd2: 1sej D:233-521 [105462]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
      5. 1038929Domain d1seje2: 1sej E:233-521 [105464]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
    4. Domains for 2oip:
      1. 1038915Domain d2oipa2: 2oip A:181-521 [148785]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
      2. 1038916Domain d2oipb2: 2oip B:181-521 [148787]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
      3. 1038917Domain d2oipc2: 2oip C:186-521 [148789]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
      4. 1038918Domain d2oipd2: 2oip D:181-521 [148791]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
      5. 1038919Domain d2oipe2: 2oip E:181-521 [148793]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
  2. 1038930Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88964] (2 PDB entries)
    1. Domains for 1j3i:
      1. 1038933Domain d1j3ic_: 1j3i C: [84064]
        Other proteins in same PDB: d1j3ia_, d1j3ib_
        complexed with ndp, ump, wra
      2. 1038934Domain d1j3id_: 1j3i D: [84065]
        Other proteins in same PDB: d1j3ia_, d1j3ib_
        complexed with ndp, ump, wra
    2. Domains for 1j3k:
      1. 1038931Domain d1j3kc_: 1j3k C: [84072]
        Other proteins in same PDB: d1j3ka_, d1j3kb_
        complexed with ndp, ump, wra; mutant
      2. 1038932Domain d1j3kd_: 1j3k D: [84073]
        Other proteins in same PDB: d1j3ka_, d1j3kb_
        complexed with ndp, ump, wra; mutant

More info for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

Timeline for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase: