Lineage for Protein: Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain

  1. Root: SCOP 1.75
  2. 849709Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 871398Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 871399Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (1 family) (S)
  5. 871400Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (3 proteins)
  6. 871401Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

Species:

  1. 871402Cryptosporidium hominis [TaxId:237895] [100887] (4 PDB entries)
    1. Domains for 1j3j:
      1. 871403Domain d1j3jc_: 1j3j C: [84068]
        Other proteins in same PDB: d1j3ja_, d1j3jb_
      2. 871404Domain d1j3jd_: 1j3j D: [84069]
        Other proteins in same PDB: d1j3ja_, d1j3jb_
        complexed with cp6, ndp, ump; mutant
    2. Domains for 1qzf:
      1. 871410Domain d1qzfa2: 1qzf A:181-521 [96634]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
      2. 871411Domain d1qzfb2: 1qzf B:181-521 [96636]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
      3. 871412Domain d1qzfc2: 1qzf C:181-521 [96638]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
      4. 871413Domain d1qzfd2: 1qzf D:181-521 [96640]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
      5. 871414Domain d1qzfe2: 1qzf E:181-521 [96642]
        Other proteins in same PDB: d1qzfa1, d1qzfb1, d1qzfc1, d1qzfd1, d1qzfe1
        complexed with cb3, fol, ndp, ump
    3. Domains for 1sej:
      1. 871405Domain d1seja2: 1sej A:233-521 [105456]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
      2. 871406Domain d1sejb2: 1sej B:233-521 [105458]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
      3. 871407Domain d1sejc2: 1sej C:233-521 [105460]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
      4. 871408Domain d1sejd2: 1sej D:233-521 [105462]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
      5. 871409Domain d1seje2: 1sej E:233-521 [105464]
        Other proteins in same PDB: d1seja1, d1sejb1, d1sejc1, d1sejd1, d1seje1
        Q5CGA3 Q27552
        complexed with f89, ndp, ump
    4. Domains for 2oip:
      1. 871415Domain d2oipa2: 2oip A:181-521 [148785]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
      2. 871416Domain d2oipb2: 2oip B:181-521 [148787]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
      3. 871417Domain d2oipc2: 2oip C:186-521 [148789]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
      4. 871418Domain d2oipd2: 2oip D:181-521 [148791]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
      5. 871419Domain d2oipe2: 2oip E:181-521 [148793]
        Other proteins in same PDB: d2oipa1, d2oipb1, d2oipc1, d2oipd1, d2oipe1
        automatically matched to d1qzfa2
        complexed with cb3, mtx, ndp, ump; mutant
  2. 871420Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88964] (2 PDB entries)
    1. Domains for 1j3i:
      1. 871423Domain d1j3ic_: 1j3i C: [84064]
        Other proteins in same PDB: d1j3ia_, d1j3ib_
      2. 871424Domain d1j3id_: 1j3i D: [84065]
        Other proteins in same PDB: d1j3ia_, d1j3ib_
        complexed with ndp, ump, wra
    2. Domains for 1j3k:
      1. 871421Domain d1j3kc_: 1j3k C: [84072]
        Other proteins in same PDB: d1j3ka_, d1j3kb_
      2. 871422Domain d1j3kd_: 1j3k D: [84073]
        Other proteins in same PDB: d1j3ka_, d1j3kb_
        complexed with ndp, ump, wra; mutant

More info for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

Timeline for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase: