Lineage for Protein: Thymidylate synthase

  1. Root: SCOPe 2.05
  2. 1886641Class d: Alpha and beta proteins (a+b) [53931] (381 folds)
  3. 1923787Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 1923788Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (2 families) (S)
    automatically mapped to Pfam PF00303
  5. 1923789Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)
  6. 1923827Protein Thymidylate synthase [55833] (7 species)

Species:

  1. 1923828Bacillus subtilis [TaxId:1423] [55836] (5 PDB entries)
    1. Domain for 1b02:
    2. Domains for 1bko:
      1. 1923836Domain d1bkoa_: 1bko A: [41036]
      2. 1923837Domain d1bkob_: 1bko B: [41037]
      3. 1923838Domain d1bkoc_: 1bko C: [41038]
      4. 1923839Domain d1bkod_: 1bko D: [41039]
    3. Domains for 1bkp:
      1. 1923829Domain d1bkpa_: 1bkp A: [41029]
      2. 1923830Domain d1bkpb_: 1bkp B: [41030]
    4. Domains for 1bsf:
      1. 1923833Domain d1bsfa_: 1bsf A: [41033]
      2. 1923834Domain d1bsfb_: 1bsf B: [41034]
    5. Domains for 1bsp:
      1. 1923831Domain d1bspa_: 1bsp A: [41031]
        complexed with po4
      2. 1923832Domain d1bspb_: 1bsp B: [41032]
        complexed with po4
  2. 1923840Bacteriophage T4 [TaxId:10665] [55837] (1 PDB entry)
  3. 1923842Escherichia coli [TaxId:562] [55834] (64 PDB entries)
    1. Domains for 1aiq:
      1. 1923904Domain d1aiqa_: 1aiq A: [40967]
        complexed with cb3, ump; mutant
      2. 1923905Domain d1aiqb_: 1aiq B: [40968]
        complexed with cb3, ump; mutant
    2. Domain for 1ajm:
    3. Domains for 1an5:
      1. 1923938Domain d1an5a_: 1an5 A: [40986]
        complexed with cb3, po4
      2. 1923939Domain d1an5b_: 1an5 B: [40987]
        complexed with cb3, po4
    4. Domain for 1aob:
    5. Domains for 1axw:
      1. 1923865Domain d1axwa_: 1axw A: [40938]
        complexed with mtx, ump
      2. 1923866Domain d1axwb_: 1axw B: [40939]
        complexed with mtx, ump
    6. Domain for 1bdu:
    7. Domain for 1bid:
    8. Domain for 1bjg:
    9. Domains for 1bq1:
      1. 1923906Domain d1bq1a_: 1bq1 A: [40965]
        complexed with cb3, ump; mutant
      2. 1923907Domain d1bq1b_: 1bq1 B: [40966]
        complexed with cb3, ump; mutant
    10. Domain for 1bq2:
    11. Domains for 1ddu:
      1. 1923910Domain d1ddua_: 1ddu A: [40961]
        complexed with cb3, ddu, po4
      2. 1923911Domain d1ddub_: 1ddu B: [40962]
        complexed with cb3, ddu, po4
    12. Domains for 1dna:
      1. 1923899Domain d1dnaa_: 1dna A: [40956]
        complexed with cb3, ump; mutant
      2. 1923900Domain d1dnab_: 1dna B: [40957]
        complexed with cb3, ump; mutant
    13. Domain for 1ev5:
    14. Domain for 1ev8:
    15. Domain for 1evf:
    16. Domain for 1evg:
    17. Domain for 1f4b:
    18. Domains for 1f4c:
      1. 1923885Domain d1f4ca_: 1f4c A: [40950]
        complexed with gol, so4, tp2
      2. 1923886Domain d1f4cb_: 1f4c B: [40951]
        complexed with gol, so4, tp2
    19. Domains for 1f4d:
      1. 1923917Domain d1f4da_: 1f4d A: [40972]
        complexed with gol, so4, tp2
      2. 1923918Domain d1f4db_: 1f4d B: [40973]
        complexed with gol, so4, tp2
    20. Domain for 1f4e:
    21. Domains for 1f4f:
      1. 1923875Domain d1f4fa_: 1f4f A: [40946]
        complexed with so4, tp3
      2. 1923876Domain d1f4fb_: 1f4f B: [40947]
        complexed with so4, tp3
    22. Domains for 1f4g:
      1. 1923857Domain d1f4ga_: 1f4g A: [40933]
        complexed with gol, so4, tp4
      2. 1923858Domain d1f4gb_: 1f4g B: [40934]
        complexed with gol, so4, tp4
    23. Domain for 1ffl:
    24. Domains for 1fwm:
      1. 1923914Domain d1fwma_: 1fwm A: [90500]
        complexed with cb3, so4; mutant
      2. 1923915Domain d1fwmb_: 1fwm B: [90501]
        complexed with cb3, so4; mutant
    25. Domains for 1jg0:
      1. 1923889Domain d1jg0a_: 1jg0 A: [66659]
        complexed with ddt, ump
      2. 1923890Domain d1jg0b_: 1jg0 B: [66660]
        complexed with ddt, ump
    26. Domains for 1jtq:
      1. 1923931Domain d1jtqa_: 1jtq A: [63282]
        complexed with ly3, ump
      2. 1923932Domain d1jtqb_: 1jtq B: [63283]
        complexed with ly3, ump
    27. Domains for 1jtu:
      1. 1923922Domain d1jtua_: 1jtu A: [63284]
        complexed with lyb, ump
      2. 1923923Domain d1jtub_: 1jtu B: [63285]
        complexed with lyb, ump
    28. Domains for 1jut:
      1. 1923951Domain d1juta_: 1jut A: [63301]
        complexed with lyd, ump
      2. 1923952Domain d1jutb_: 1jut B: [63302]
        complexed with lyd, ump
    29. Domains for 1kce:
      1. 1923872Domain d1kcea_: 1kce A: [40944]
        complexed with cb3, ump; mutant
      2. 1923873Domain d1kceb_: 1kce B: [40945]
        complexed with cb3, ump; mutant
    30. Domains for 1kzi:
      1. 1923862Domain d1kzia_: 1kzi A: [73363]
        complexed with co3, dtt, dtu, gol, thg, ump
      2. 1923863Domain d1kzib_: 1kzi B: [73364]
        complexed with co3, dtt, dtu, gol, thg, ump
    31. Domains for 1kzj:
      1. 1923944Domain d1kzja_: 1kzj A: [73365]
        complexed with cb3, ump
      2. 1923945Domain d1kzjb_: 1kzj B: [73366]
        complexed with cb3, ump
      3. 1923946Domain d1kzjc_: 1kzj C: [73367]
        complexed with cb3, ump
      4. 1923947Domain d1kzjd_: 1kzj D: [73368]
        complexed with cb3, ump
      5. 1923948Domain d1kzje_: 1kzj E: [73369]
        complexed with cb3, ump
      6. 1923949Domain d1kzjf_: 1kzj F: [73370]
        complexed with cb3, ump
    32. Domains for 1nce:
      1. 1923928Domain d1ncea_: 1nce A: [80401]
        complexed with cb3, ump
      2. 1923929Domain d1nceb_: 1nce B: [80402]
        complexed with cb3, ump
    33. Domain for 1qqq:
    34. Domains for 1syn:
      1. 1923895Domain d1syna_: 1syn A: [40958]
        complexed with f89, ump
      2. 1923896Domain d1synb_: 1syn B: [40959]
        complexed with f89, ump
    35. Domains for 1tdu:
      1. 1923902Domain d1tdua_: 1tdu A: [40963]
        complexed with cb3, dur, po4
      2. 1923903Domain d1tdub_: 1tdu B: [40964]
        complexed with cb3, dur, po4
    36. Domain for 1tjs:
    37. Domains for 1tlc:
      1. 1923897Domain d1tlca_: 1tlc A: [40942]
        complexed with dgp, f89
      2. 1923898Domain d1tlcb_: 1tlc B: [40943]
        complexed with dgp, f89
    38. Domains for 1tls:
      1. 1923933Domain d1tlsa_: 1tls A: [40982]
        complexed with c2f, ufp
      2. 1923934Domain d1tlsb_: 1tls B: [40983]
        complexed with c2f, ufp
    39. Domain for 1trg:
    40. Domains for 1tsd:
      1. 1923892Domain d1tsda_: 1tsd A: [40948]
        complexed with bme, f89, ump
      2. 1923893Domain d1tsdb_: 1tsd B: [40949]
        complexed with bme, f89, ump
    41. Domain for 1tsn:
    42. Domain for 1tys:
    43. Domains for 1zpr:
      1. 1923925Domain d1zpra_: 1zpr A: [40978]
        complexed with cb3, ump; mutant
      2. 1923926Domain d1zprb_: 1zpr B: [40979]
        complexed with cb3, ump; mutant
    44. Domains for 2a9w:
      1. 1923851Domain d2a9wa_: 2a9w A: [126456]
        automated match to d1an5a_
        complexed with 2br, bme, ga9, gol, po4, ump
      2. 1923852Domain d2a9wb_: 2a9w B: [126457]
        automated match to d1an5a_
        complexed with 2br, bme, ga9, gol, po4, ump
      3. 1923853Domain d2a9wc_: 2a9w C: [126458]
        automated match to d1an5a_
        complexed with 2br, bme, ga9, gol, po4, ump
      4. 1923854Domain d2a9wd_: 2a9w D: [126459]
        automated match to d1an5a_
        complexed with 2br, bme, ga9, gol, po4, ump
    45. Domains for 2bbq:
      1. 1923920Domain d2bbqa_: 2bbq A: [40974]
        complexed with pfg, ump
      2. 1923921Domain d2bbqb_: 2bbq B: [40975]
        complexed with pfg, ump
    46. Domain for 2ftn:
    47. Domain for 2fto:
    48. Domain for 2ftq:
    49. Domains for 2g8x:
      1. 1923859Domain d2g8xa_: 2g8x A: [164605]
        automated match to d1an5a_
        complexed with co3, dtt, po4
      2. 1923860Domain d2g8xb_: 2g8x B: [164606]
        automated match to d1an5a_
        complexed with co3, dtt, po4
    50. Domains for 2kce:
      1. 1923936Domain d2kcea_: 2kce A: [40984]
        complexed with d16, ump
      2. 1923937Domain d2kceb_: 2kce B: [40985]
        complexed with d16, ump
    51. Domains for 2tsc:
      1. 1923887Domain d2tsca_: 2tsc A: [40952]
        complexed with cb3, ump
      2. 1923888Domain d2tscb_: 2tsc B: [40953]
        complexed with cb3, ump
    52. Domain for 2vet:
    53. Domains for 2vf0:
      1. 1923953Domain d2vf0a_: 2vf0 A: [243863]
        automated match to d2veta_
        protein/RNA complex; complexed with f89, ndu, so4
      2. 1923954Domain d2vf0b_: 2vf0 B: [243864]
        automated match to d2veta_
        protein/RNA complex; complexed with f89, ndu, so4
    54. Domains for 3b5b:
      1. 1923940Domain d3b5ba_: 3b5b A: [172428]
        automated match to d1aiqa_
        complexed with fmt, ndn, ndu
      2. 1923941Domain d3b5bb_: 3b5b B: [172429]
        automated match to d1aiqa_
        complexed with fmt, ndn, ndu
    55. Domain for 3b9h:
    56. Domain for 3bfi:
    57. Domain for 3bgx:
      • 1923871Domain d3bgxa_: 3bgx A: [172629]
        automated match to d1an5a_
        protein/RNA complex; complexed with mef, so4, tmp; mutant
    58. Domains for 3bhl:
      1. 1923847Domain d3bhla_: 3bhl A: [172637]
        automated match to d1aiqa_
        protein/RNA complex; complexed with ndu, so4, thg
      2. 1923848Domain d3bhlb_: 3bhl B: [172638]
        automated match to d1aiqa_
        protein/RNA complex; complexed with ndu, so4, thg
    59. Domain for 3bhr:
    60. Domain for 3tms:
    61. Domains for 4gev:
      1. 1923843Domain d4geva_: 4gev A: [192445]
        automated match to d2g8ma_
        complexed with cb3, umc
      2. 1923844Domain d4gevb_: 4gev B: [192446]
        automated match to d2g8ma_
        complexed with cb3, umc
    62. Domains for 4isk:
      1. 1923877Domain d4iska_: 4isk A: [230059]
        automated match to d1f4ba_
        complexed with 1jy, mg, umc, ump
      2. 1923878Domain d4iskb_: 4isk B: [230056]
        automated match to d1f4ba_
        complexed with 1jy, mg, umc, ump
      3. 1923879Domain d4iskc_: 4isk C: [230058]
        automated match to d1f4ba_
        complexed with 1jy, mg, umc, ump
      4. 1923880Domain d4iskd_: 4isk D: [230057]
        automated match to d1f4ba_
        complexed with 1jy, mg, umc, ump
      5. 1923881Domain d4iske_: 4isk E: [230060]
        automated match to d1f4ba_
        complexed with 1jy, mg, umc, ump
      6. 1923882Domain d4iskf_: 4isk F: [230063]
        automated match to d1f4ba_
        complexed with 1jy, mg, umc, ump
      7. 1923883Domain d4iskg_: 4isk G: [230061]
        automated match to d1f4ba_
        complexed with 1jy, mg, umc, ump
      8. 1923884Domain d4iskh_: 4isk H: [230062]
        automated match to d1f4ba_
        complexed with 1jy, mg, umc, ump
    63. Domains for 4knz:
      1. 1923845Domain d4knza_: 4knz A: [192989]
        automated match to d2g8oa_
        complexed with cb3, na, umc
      2. 1923846Domain d4knzb_: 4knz B: [192990]
        automated match to d2g8oa_
        complexed with cb3, na, umc
    64. Domain for 4lrr:
  4. 1923955Fungus (Pneumocystis carinii) [TaxId:4754] [55838] (2 PDB entries)
    1. Domains for 1ci7:
      1. 1923960Domain d1ci7a_: 1ci7 A: [41041]
        complexed with cb3, ump
      2. 1923961Domain d1ci7b_: 1ci7 B: [41042]
        complexed with cb3, ump
    2. Domains for 1f28:
      1. 1923956Domain d1f28a_: 1f28 A: [59608]
        complexed with f89, ump
      2. 1923957Domain d1f28b_: 1f28 B: [59609]
        complexed with f89, ump
      3. 1923958Domain d1f28c_: 1f28 C: [59610]
        complexed with f89, ump
      4. 1923959Domain d1f28d_: 1f28 D: [59611]
        complexed with f89, ump
  5. 1923962Human (Homo sapiens) [TaxId:9606] [55840] (24 PDB entries)
    1. Domains for 1hvy:
      1. 1923963Domain d1hvya_: 1hvy A: [41049]
        complexed with bme, d16, ump
      2. 1923964Domain d1hvyb_: 1hvy B: [41050]
        complexed with bme, d16, ump
      3. 1923965Domain d1hvyc_: 1hvy C: [41051]
        complexed with bme, d16, ump
      4. 1923966Domain d1hvyd_: 1hvy D: [41052]
        complexed with bme, d16, ump
    2. Domain for 1hw3:
    3. Domain for 1hw4:
    4. Domains for 1hzw:
      1. 1923969Domain d1hzwa_: 1hzw A: [61464]
        complexed with po4
      2. 1923970Domain d1hzwb_: 1hzw B: [61465]
        complexed with po4
    5. Domains for 1i00:
      1. 1923977Domain d1i00a_: 1i00 A: [61475]
        complexed with d16, ump
      2. 1923978Domain d1i00b_: 1i00 B: [61476]
        complexed with d16, ump
    6. Domains for 1ju6:
      1. 1924006Domain d1ju6a_: 1ju6 A: [63289]
        complexed with lya, po4, ump
      2. 1924007Domain d1ju6b_: 1ju6 B: [63290]
        complexed with lya, po4, ump
      3. 1924008Domain d1ju6c_: 1ju6 C: [63291]
        complexed with lya, po4, ump
      4. 1924009Domain d1ju6d_: 1ju6 D: [63292]
        complexed with lya, po4, ump
    7. Domains for 1juj:
      1. 1924015Domain d1juja_: 1juj A: [63297]
        complexed with lya, ump
      2. 1924016Domain d1jujb_: 1juj B: [63298]
        complexed with lya, ump
      3. 1924017Domain d1jujc_: 1juj C: [63299]
        complexed with lya, ump
      4. 1924018Domain d1jujd_: 1juj D: [63300]
        complexed with lya, ump
    8. Domain for 1ypv:
    9. Domain for 2onb:
    10. Domains for 2rd8:
      1. 1923980Domain d2rd8a_: 2rd8 A: [206084]
        automated match to d2aaza_
        complexed with bme, po4; mutant
      2. 1923981Domain d2rd8b_: 2rd8 B: [206085]
        automated match to d2aaza_
        complexed with bme, po4; mutant
    11. Domains for 2rda:
      1. 1923995Domain d2rdaa_: 2rda A: [206086]
        automated match to d2aaza_
        complexed with bme, po4; mutant
      2. 1923996Domain d2rdab_: 2rda B: [206087]
        automated match to d2aaza_
        complexed with bme, po4; mutant
      3. 1923997Domain d2rdac_: 2rda C: [206088]
        automated match to d2aaza_
        complexed with bme, po4; mutant
      4. 1923998Domain d2rdad_: 2rda D: [206089]
        automated match to d2aaza_
        complexed with bme, po4; mutant
      5. 1923999Domain d2rdae_: 2rda E: [206090]
        automated match to d2aaza_
        complexed with bme, po4; mutant
      6. 1924000Domain d2rdaf_: 2rda F: [206091]
        automated match to d2aaza_
        complexed with bme, po4; mutant
    12. Domain for 3egy:
    13. Domain for 3ehi:
    14. Domains for 3h9k:
      1. 1923982Domain d3h9ka_: 3h9k A: [210912]
        automated match to d2aaza_
        complexed with edo, po4, ufp
      2. 1923983Domain d3h9kb_: 3h9k B: [210913]
        automated match to d2aaza_
        complexed with edo, po4, ufp
      3. 1923984Domain d3h9kc_: 3h9k C: [210914]
        automated match to d2aaza_
        complexed with edo, po4, ufp
      4. 1923985Domain d3h9kd_: 3h9k D: [210915]
        automated match to d2aaza_
        complexed with edo, po4, ufp
      5. 1923986Domain d3h9ke_: 3h9k E: [210916]
        automated match to d2aaza_
        complexed with edo, po4, ufp
    15. Domains for 3hb8:
      1. 1923987Domain d3hb8a_: 3hb8 A: [210970]
        automated match to d2aaza_
        complexed with edo, po4, ump
      2. 1923988Domain d3hb8b_: 3hb8 B: [210971]
        automated match to d2aaza_
        complexed with edo, po4, ump
      3. 1923989Domain d3hb8c_: 3hb8 C: [210972]
        automated match to d2aaza_
        complexed with edo, po4, ump
      4. 1923990Domain d3hb8d_: 3hb8 D: [210973]
        automated match to d2aaza_
        complexed with edo, po4, ump
      5. 1923991Domain d3hb8e_: 3hb8 E: [210974]
        automated match to d2aaza_
        complexed with edo, po4, ump
    16. Domain for 3n5g:
    17. Domains for 3ob7:
      1. 1924001Domain d3ob7a_: 3ob7 A: [214286]
        automated match to d2aaza_
        complexed with gsh, po4
      2. 1924002Domain d3ob7b_: 3ob7 B: [214287]
        automated match to d2aaza_
        complexed with gsh, po4
      3. 1924003Domain d3ob7c_: 3ob7 C: [214288]
        automated match to d2aaza_
        complexed with gsh, po4
      4. 1924004Domain d3ob7d_: 3ob7 D: [214289]
        automated match to d2aaza_
        complexed with gsh, po4
      5. 1924005Domain d3ob7e_: 3ob7 E: [214290]
        automated match to d2aaza_
        complexed with gsh, po4
    18. Domain for 4e28:
    19. Domain for 4g6w:
    20. Domain for 4gd7:
    21. Domain for 4gyh:
    22. Domains for 4h1i:
      1. 1924011Domain d4h1ia_: 4h1i A: [252362]
        automated match to d4eb4a_
        complexed with so4
      2. 1924012Domain d4h1ib_: 4h1i B: [252363]
        automated match to d4eb4a_
        complexed with so4
      3. 1924013Domain d4h1ic_: 4h1i C: [252364]
        automated match to d4eb4a_
        complexed with so4
      4. 1924014Domain d4h1id_: 4h1i D: [252365]
        automated match to d4eb4a_
        complexed with so4
    23. Domain for 4jef:
    24. Domain for 4kpw:
  6. 1924019Lactobacillus casei [TaxId:1582] [55835] (51 PDB entries)
    1. Domain for 1bo7:
    2. Domain for 1bo8:
    3. Domain for 1bp0:
    4. Domain for 1bp6:
    5. Domain for 1bpj:
    6. Domain for 1jmf:
    7. Domain for 1jmg:
    8. Domain for 1jmh:
    9. Domain for 1jmi:
    10. Domain for 1lca:
    11. Domain for 1lcb:
    12. Domain for 1lce:
    13. Domain for 1nja:
    14. Domain for 1njb:
    15. Domain for 1njc:
    16. Domain for 1njd:
    17. Domain for 1nje:
    18. Domain for 1tda:
    19. Domain for 1tdb:
    20. Domain for 1tdc:
    21. Domain for 1thy:
    22. Domain for 1tsl:
    23. Domain for 1tsm:
    24. Domain for 1tsv:
    25. Domain for 1tsw:
    26. Domain for 1tsx:
    27. Domain for 1tsy:
    28. Domain for 1tsz:
    29. Domain for 1tvu:
    30. Domain for 1tvv:
    31. Domain for 1tvw:
    32. Domain for 1vza:
    33. Domain for 1vzb:
    34. Domain for 1vzc:
    35. Domain for 1vzd:
    36. Domain for 1vze:
    37. Domain for 2g86:
    38. Domain for 2g89:
    39. Domain for 2g8a:
    40. Domain for 2g8d:
    41. Domain for 2tdd:
    42. Domain for 2tdm:
    43. Domain for 3bnz:
    44. Domain for 3byx:
    45. Domain for 3bz0:
    46. Domain for 3c06:
    47. Domain for 3c0a:
    48. Domain for 3ijz:
    49. Domain for 3ik0:
    50. Domain for 3ik1:
    51. Domain for 4tms:
  7. 1924071Norway rat (Rattus norvegicus) [TaxId:10116] [55839] (2 PDB entries)
    1. Domains for 1rts:
      1. 1924076Domain d1rtsa_: 1rts A: [41047]
        complexed with d16, ump
      2. 1924077Domain d1rtsb_: 1rts B: [41048]
        complexed with d16, ump
    2. Domains for 2tsr:
      1. 1924072Domain d2tsra_: 2tsr A: [41043]
        complexed with d16, ump
      2. 1924073Domain d2tsrb_: 2tsr B: [41044]
        complexed with d16, ump
      3. 1924074Domain d2tsrc_: 2tsr C: [41045]
        complexed with d16, ump
      4. 1924075Domain d2tsrd_: 2tsr D: [41046]
        complexed with d16, ump

More info for Protein Thymidylate synthase from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

Timeline for Protein Thymidylate synthase from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase: