Lineage for Protein: Thymidylate synthase

  1. Root: SCOP 1.73
  2. 713694Class d: Alpha and beta proteins (a+b) [53931] (334 folds)
  3. 732217Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
    contains large mixed beta-sheet
  4. 732218Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (1 family) (S)
  5. 732219Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (3 proteins)
  6. 732247Protein Thymidylate synthase [55833] (7 species)

Species:

  1. 732248Bacillus subtilis [TaxId:1423] [55836] (5 PDB entries)
    1. Domain for 1b02:
    2. Domains for 1bko:
      1. 732256Domain d1bkoa_: 1bko A: [41036]
      2. 732257Domain d1bkob_: 1bko B: [41037]
      3. 732258Domain d1bkoc_: 1bko C: [41038]
      4. 732259Domain d1bkod_: 1bko D: [41039]
    3. Domains for 1bkp:
      1. 732249Domain d1bkpa_: 1bkp A: [41029]
      2. 732250Domain d1bkpb_: 1bkp B: [41030]
    4. Domains for 1bsf:
      1. 732253Domain d1bsfa_: 1bsf A: [41033]
      2. 732254Domain d1bsfb_: 1bsf B: [41034]
    5. Domains for 1bsp:
      1. 732251Domain d1bspa_: 1bsp A: [41031]
      2. 732252Domain d1bspb_: 1bsp B: [41032]
        complexed with po4
  2. 732260Bacteriophage T4 [TaxId:10665] [55837] (1 PDB entry)
  3. 732262Escherichia coli [TaxId:562] [55834] (52 PDB entries)
    1. Domains for 1aiq:
      1. 732303Domain d1aiqa_: 1aiq A: [40967]
      2. 732304Domain d1aiqb_: 1aiq B: [40968]
        complexed with cb3, ump; mutant
    2. Domain for 1ajm:
    3. Domains for 1an5:
      1. 732333Domain d1an5a_: 1an5 A: [40986]
      2. 732334Domain d1an5b_: 1an5 B: [40987]
        complexed with cb3, cbx, po4
    4. Domain for 1aob:
    5. Domains for 1axw:
      1. 732274Domain d1axwa_: 1axw A: [40938]
      2. 732275Domain d1axwb_: 1axw B: [40939]
        complexed with cbx, mtx, ump
    6. Domain for 1bdu:
    7. Domain for 1bid:
    8. Domain for 1bjg:
    9. Domains for 1bq1:
      1. 732307Domain d1bq1a_: 1bq1 A: [40965]
      2. 732308Domain d1bq1b_: 1bq1 B: [40966]
        complexed with cb3, ump; mutant
    10. Domain for 1bq2:
    11. Domains for 1ddu:
      1. 732309Domain d1ddua_: 1ddu A: [40961]
      2. 732310Domain d1ddub_: 1ddu B: [40962]
        complexed with cb3, cbx, ddu, po4
    12. Domains for 1dna:
      1. 732299Domain d1dnaa_: 1dna A: [40956]
      2. 732300Domain d1dnab_: 1dna B: [40957]
        complexed with cb3, ump; mutant
    13. Domain for 1ev5:
    14. Domain for 1ev8:
    15. Domain for 1evf:
    16. Domain for 1evg:
    17. Domain for 1f4b:
    18. Domains for 1f4c:
      1. 732289Domain d1f4ca_: 1f4c A: [40950]
      2. 732290Domain d1f4cb_: 1f4c B: [40951]
        complexed with gol, sul, tp2
    19. Domains for 1f4d:
      1. 732317Domain d1f4da_: 1f4d A: [40972]
      2. 732318Domain d1f4db_: 1f4d B: [40973]
        complexed with gol, sul, tp2; mutant
    20. Domain for 1f4e:
    21. Domains for 1f4f:
      1. 732287Domain d1f4fa_: 1f4f A: [40946]
      2. 732288Domain d1f4fb_: 1f4f B: [40947]
        complexed with sul, tp3
    22. Domains for 1f4g:
      1. 732272Domain d1f4ga_: 1f4g A: [40933]
      2. 732273Domain d1f4gb_: 1f4g B: [40934]
        complexed with gol, mho, sul, tp4
    23. Domain for 1ffl:
    24. Domains for 1fwm:
      1. 732314Domain d1fwma_: 1fwm A: [90500]
      2. 732315Domain d1fwmb_: 1fwm B: [90501]
        complexed with cb3, so4; mutant
    25. Domains for 1jg0:
      1. 732296Domain d1jg0a_: 1jg0 A: [66659]
      2. 732297Domain d1jg0b_: 1jg0 B: [66660]
        complexed with ddt, ump
    26. Domains for 1jtq:
      1. 732327Domain d1jtqa_: 1jtq A: [63282]
      2. 732328Domain d1jtqb_: 1jtq B: [63283]
        complexed with ly3, ump
    27. Domains for 1jtu:
      1. 732321Domain d1jtua_: 1jtu A: [63284]
      2. 732322Domain d1jtub_: 1jtu B: [63285]
        complexed with lyb, ump
    28. Domains for 1ju6:
      1. 732349Domain d1ju6a_: 1ju6 A: [63289]
      2. 732350Domain d1ju6b_: 1ju6 B: [63290]
      3. 732351Domain d1ju6c_: 1ju6 C: [63291]
      4. 732352Domain d1ju6d_: 1ju6 D: [63292]
        complexed with lya, po4, ump; mutant
    29. Domains for 1juj:
      1. 732353Domain d1juja_: 1juj A: [63297]
      2. 732354Domain d1jujb_: 1juj B: [63298]
      3. 732355Domain d1jujc_: 1juj C: [63299]
      4. 732356Domain d1jujd_: 1juj D: [63300]
        complexed with lya, ump; mutant
    30. Domains for 1jut:
      1. 732347Domain d1juta_: 1jut A: [63301]
      2. 732348Domain d1jutb_: 1jut B: [63302]
        complexed with lyd, ump
    31. Domains for 1kce:
      1. 732283Domain d1kcea_: 1kce A: [40944]
      2. 732284Domain d1kceb_: 1kce B: [40945]
        complexed with cb3, ump; mutant
    32. Domains for 1kzi:
      1. 732277Domain d1kzia_: 1kzi A: [73363]
      2. 732278Domain d1kzib_: 1kzi B: [73364]
        complexed with co3, cxm, dtt, gol, thg, ump
    33. Domains for 1kzj:
      1. 732340Domain d1kzja_: 1kzj A: [73365]
      2. 732341Domain d1kzjb_: 1kzj B: [73366]
      3. 732342Domain d1kzjc_: 1kzj C: [73367]
      4. 732343Domain d1kzjd_: 1kzj D: [73368]
      5. 732344Domain d1kzje_: 1kzj E: [73369]
      6. 732345Domain d1kzjf_: 1kzj F: [73370]
        complexed with cb3, cxm, ump; mutant
    34. Domains for 1nce:
      1. 732329Domain d1ncea_: 1nce A: [80401]
      2. 732330Domain d1nceb_: 1nce B: [80402]
        complexed with cb3, cxm, ump; mutant
    35. Domain for 1qqq:
    36. Domains for 1syn:
      1. 732301Domain d1syna_: 1syn A: [40958]
      2. 732302Domain d1synb_: 1syn B: [40959]
        complexed with cbx, f89, ump
    37. Domains for 1tdu:
      1. 732311Domain d1tdua_: 1tdu A: [40963]
      2. 732312Domain d1tdub_: 1tdu B: [40964]
        complexed with cb3, cbx, dur, po4
    38. Domain for 1tjs:
    39. Domains for 1tlc:
      1. 732285Domain d1tlca_: 1tlc A: [40942]
      2. 732286Domain d1tlcb_: 1tlc B: [40943]
        complexed with cbx, dgp, f89
    40. Domains for 1tls:
      1. 732335Domain d1tlsa_: 1tls A: [40982]
      2. 732336Domain d1tlsb_: 1tls B: [40983]
        complexed with c2f, ufp
    41. Domain for 1trg:
    42. Domains for 1tsd:
      1. 732291Domain d1tsda_: 1tsd A: [40948]
      2. 732292Domain d1tsdb_: 1tsd B: [40949]
        complexed with bme, cbx, u18, ump
    43. Domain for 1tsn:
    44. Domain for 1tys:
    45. Domains for 1zpr:
      1. 732325Domain d1zpra_: 1zpr A: [40978]
      2. 732326Domain d1zprb_: 1zpr B: [40979]
        complexed with cb3, ump; mutant
    46. Domains for 2a9w:
      1. 732267Domain d2a9wa1: 2a9w A:1-264 [126456]
        automatically matched to d1tlca_
        complexed with 2br, bme, ga9, gol, po4, ump
      2. 732268Domain d2a9wb1: 2a9w B:1-264 [126457]
        automatically matched to d1tlca_
        complexed with 2br, bme, ga9, gol, po4, ump
      3. 732269Domain d2a9wc1: 2a9w C:1-264 [126458]
        automatically matched to d1tlca_
        complexed with 2br, bme, ga9, gol, po4, ump
      4. 732270Domain d2a9wd1: 2a9w D:1-264 [126459]
        automatically matched to d1tlca_
        complexed with 2br, bme, ga9, gol, po4, ump
    47. Domains for 2bbq:
      1. 732319Domain d2bbqa_: 2bbq A: [40974]
      2. 732320Domain d2bbqb_: 2bbq B: [40975]
        complexed with pfg, ump
    48. Domain for 2ftq:
    49. Domains for 2g8o:
      1. 732263Domain d2g8oa1: 2g8o A:1-264 [134779]
        automatically matched to d1tlca_
        complexed with cb3, ump
      2. 732264Domain d2g8ob1: 2g8o B:1-264 [134780]
        automatically matched to d1tlca_
        complexed with cb3, ump
    50. Domains for 2kce:
      1. 732337Domain d2kcea_: 2kce A: [40984]
      2. 732338Domain d2kceb_: 2kce B: [40985]
        complexed with d16, ump
    51. Domains for 2tsc:
      1. 732293Domain d2tsca_: 2tsc A: [40952]
      2. 732294Domain d2tscb_: 2tsc B: [40953]
        complexed with cb3, ump
    52. Domain for 3tms:
  4. 732357Human (Homo sapiens) [TaxId:9606] [55840] (5 PDB entries)
    1. Domains for 1hvy:
      1. 732362Domain d1hvya_: 1hvy A: [41049]
      2. 732363Domain d1hvyb_: 1hvy B: [41050]
      3. 732364Domain d1hvyc_: 1hvy C: [41051]
      4. 732365Domain d1hvyd_: 1hvy D: [41052]
        complexed with bme, d16, ump
    2. Domain for 1hw3:
    3. Domain for 1hw4:
    4. Domains for 1hzw:
      1. 732358Domain d1hzwa_: 1hzw A: [61464]
      2. 732359Domain d1hzwb_: 1hzw B: [61465]
        complexed with po4
    5. Domains for 1i00:
      1. 732366Domain d1i00a_: 1i00 A: [61475]
      2. 732367Domain d1i00b_: 1i00 B: [61476]
        complexed with d16, ump
  5. 732368Lactobacillus casei [TaxId:1582] [55835] (39 PDB entries)
    1. Domain for 1bo7:
    2. Domain for 1bo8:
    3. Domain for 1bp0:
    4. Domain for 1bp6:
    5. Domain for 1bpj:
    6. Domain for 1jmf:
    7. Domain for 1jmg:
    8. Domain for 1jmh:
    9. Domain for 1jmi:
    10. Domain for 1lca:
    11. Domain for 1lcb:
    12. Domain for 1lce:
    13. Domain for 1nja:
    14. Domain for 1njb:
    15. Domain for 1njc:
    16. Domain for 1njd:
    17. Domain for 1nje:
    18. Domain for 1tda:
    19. Domain for 1tdb:
    20. Domain for 1tdc:
    21. Domain for 1thy:
    22. Domain for 1tsl:
    23. Domain for 1tsm:
    24. Domain for 1tsv:
    25. Domain for 1tsw:
    26. Domain for 1tsx:
    27. Domain for 1tsy:
    28. Domain for 1tsz:
    29. Domain for 1tvu:
    30. Domain for 1tvv:
    31. Domain for 1tvw:
    32. Domain for 1vza:
    33. Domain for 1vzb:
    34. Domain for 1vzc:
    35. Domain for 1vzd:
    36. Domain for 1vze:
    37. Domain for 2tdd:
    38. Domain for 2tdm:
    39. Domain for 4tms:
  6. 732408Pneumocystis carinii [TaxId:4754] [55838] (2 PDB entries)
    1. Domains for 1ci7:
      1. 732413Domain d1ci7a_: 1ci7 A: [41041]
      2. 732414Domain d1ci7b_: 1ci7 B: [41042]
        complexed with cb3, ump
    2. Domains for 1f28:
      1. 732409Domain d1f28a_: 1f28 A: [59608]
      2. 732410Domain d1f28b_: 1f28 B: [59609]
      3. 732411Domain d1f28c_: 1f28 C: [59610]
      4. 732412Domain d1f28d_: 1f28 D: [59611]
        complexed with f89, ump
  7. 732415Rat (Rattus norvegicus) [TaxId:10116] [55839] (2 PDB entries)
    1. Domains for 1rts:
      1. 732420Domain d1rtsa_: 1rts A: [41047]
      2. 732421Domain d1rtsb_: 1rts B: [41048]
        complexed with d16, ump
    2. Domains for 2tsr:
      1. 732416Domain d2tsra_: 2tsr A: [41043]
      2. 732417Domain d2tsrb_: 2tsr B: [41044]
      3. 732418Domain d2tsrc_: 2tsr C: [41045]
      4. 732419Domain d2tsrd_: 2tsr D: [41046]
        complexed with d16, ump

More info for Protein Thymidylate synthase from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

Timeline for Protein Thymidylate synthase from d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase: