SCOPe 2.02: Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

Lineage for Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.117: Thymidylate synthase/dCMP hydroxymethylase [55830] (1 superfamily)
   contains large mixed beta-sheet

4. Superfamily d.117.1: Thymidylate synthase/dCMP hydroxymethylase [55831] (1 family)

5. Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase [55832] (4 proteins)

Proteins:

1. Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, TS domain [55841] (2 species)

   1. Species Cryptosporidium hominis [TaxId:237895] [100887] (4 PDB entries)

   2. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88964] (2 PDB entries)

2. dCMP hydroxymethylase [55843] (1 species)

   • Species Bacteriophage T4 [TaxId:10665] [55844] (3 PDB entries)

3. Thymidylate synthase [55833] (7 species)

   1. Species Bacillus subtilis [TaxId:1423] [55836] (5 PDB entries)

   2. Species Bacteriophage T4 [TaxId:10665] [55837] (1 PDB entry)

   3. Species Escherichia coli [TaxId:562] [55834] (65 PDB entries)

   4. Species Fungus (Pneumocystis carinii) [TaxId:4754] [55838] (2 PDB entries)

   5. Species Human (Homo sapiens) [TaxId:9606] [55840] (5 PDB entries)

   6. Species Lactobacillus casei [TaxId:1582] [55835] (51 PDB entries)

   7. Species Norway rat (Rattus norvegicus) [TaxId:10116] [55839] (2 PDB entries)

4. automated matches [190469] (7 species)
   not a true protein

   1. Species Encephalitozoon cuniculi [TaxId:284813] [189107] (1 PDB entry)

   2. Species Enterococcus faecalis [TaxId:1351] [194752] (1 PDB entry)

   3. Species Fungus (Filobasidiella neoformans) [TaxId:5207] [187389] (1 PDB entry)

   4. Species Human (Homo sapiens) [TaxId:9606] [189245] (1 PDB entry)

   5. Species Malaria parasite (Plasmodium falciparum) [TaxId:5833] [188759] (2 PDB entries)

   6. Species Mycobacterium tuberculosis [TaxId:1773] [189990] (1 PDB entry)

   7. Species Staphylococcus aureus [TaxId:158878] [195805] (1 PDB entry)

More info for Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase

Timeline for Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase:

• Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase first appeared (with stable ids) in SCOP 1.55
  
• Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase appears in SCOPe 2.01
  
• Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase appears in SCOPe 2.03
  
• Family d.117.1.1: Thymidylate synthase/dCMP hydroxymethylase appears in the current release, SCOPe 2.08