SCOP 1.75: Family d.108.1.1: N-acetyl transferase, NAT

Lineage for Family d.108.1.1: N-acetyl transferase, NAT

1. Root: SCOP 1.75

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.108: Acyl-CoA N-acyltransferases (Nat) [55728] (1 superfamily)
   3 layers: a/b/a; contains mixed beta-sheet

4. Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) [55729] (10 families)

5. Family d.108.1.1: N-acetyl transferase, NAT [55730] (57 proteins)

Proteins:

1. Aminoglycoside 2'-N-acetyltransferase [75506] (1 species)

   • Species Mycobacterium tuberculosis [TaxId:1773] [75507] (4 PDB entries)

2. Aminoglycoside 3-N-acetyltransferase [55733] (1 species)

   • Species Serratia marcescens [TaxId:615] [55734] (1 PDB entry)

3. Aminoglycoside 6'-N-acetyltransferase [55731] (1 species)

   • Species Enterococcus faecium [TaxId:1352] [55732] (3 PDB entries)

4. Aminoglycoside N-acetyltransferase AAC(6')-IY [111098] (2 species)

   1. Species Salmonella choleraesuis [TaxId:28901] [160639] (1 PDB entry)

   2. Species Salmonella enteritidis [TaxId:149539] [111099] (3 PDB entries)
      Uniprot Q9R381

5. Catalytic domain of GCN5 histone acetyltransferase [55737] (3 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [55738] (1 PDB entry)

   2. Species Human (Homo sapiens) [TaxId:9606] [143647] (1 PDB entry)
      Uniprot Q92830 497-658

   3. Species Tetrahymena thermophila [TaxId:5911] [55739] (9 PDB entries)
      Uniprot Q27198 49-209

6. Diamine acetyltransferase 1 [143652] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [143653] (10 PDB entries)
     Uniprot P21673 2-170! Uniprot P21673 3-169

7. Diamine acetyltransferase 2 [143688] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [143689] (2 PDB entries)
     Uniprot Q96F10 3-169

8. Glucosamine-phosphate N-acetyltransferase GNA1 [64351] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64352] (3 PDB entries)

9. Histone acetyltransferase domain of P300/CBP associating factor, PCAF [55735] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [55736] (1 PDB entry)

10. Histone acetyltransferase ESA1 [55744] (1 species)
    most similar to HAT1 including the N- and C-terminal (sub)domains; the N-terminal domain contains a rudiment CCHC zinc-finger (res. 191-220); the C-terminal domain (res. 351-434) has "winged helix" DNA-binding fold

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [55745] (4 PDB entries)

11. Histone acetyltransferase HAT1 [55742] (1 species)
    contains additional N- and C-terminal (sub)domains

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [55743] (1 PDB entry)

12. Histone acetyltransferase HPA2 [55740] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [55741] (2 PDB entries)

13. Histone acetyltransferase MYST3 [143702] (1 species)
    ESA1 orthologue

    • Species Human (Homo sapiens) [TaxId:9606] [143703] (2 PDB entries)
      Uniprot Q92794 507-776
      solution structure of the zinc-binding motif have been determined in isolation (PDB 1m36, (103600))
      solution structure of the zinc-binding motif have been determined in isolation (PDB 1m36, (103600))

14. Hypothetical protein AT1g77540 [118064] (1 species)

    • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [118065] (3 PDB entries)
      Uniprot Q8LEN2

15. Hypothetical protein MW0638 [143690] (1 species)
    SA0631 ortholog

    • Species Staphylococcus aureus [TaxId:1280] [143691] (1 PDB entry)
      Uniprot Q8NXQ8 1-118

16. Hypothetical protein PA0115 [118066] (1 species)

    • Species Pseudomonas aeruginosa [TaxId:287] [118067] (1 PDB entry)
      Uniprot Q9I717

17. Hypothetical protein PA3270 [143686] (1 species)

    • Species Pseudomonas aeruginosa [TaxId:287] [143687] (1 PDB entry)
      Uniprot Q9HYX1 11-193

18. Hypothetical protein PA4866 [143694] (1 species)
    Putative phosphinothricin acetyltransferase

    • Species Pseudomonas aeruginosa [TaxId:287] [143695] (2 PDB entries)
      Uniprot Q9HUU7 3-172! Uniprot Q9HUU7 4-172

19. Hypothetical protein PH0736 [143666] (1 species)

    • Species Pyrococcus horikoshii [TaxId:53953] [143667] (1 PDB entry)
      Uniprot O58467 1-182

20. Hypothetical protein PH1933 [143648] (1 species)

    • Species Pyrococcus horikoshii [TaxId:53953] [143649] (1 PDB entry)
      Uniprot O59596 1-157

21. Hypothetical protein Rv1347c/MT1389 [143668] (1 species)

    • Species Mycobacterium tuberculosis [TaxId:1773] [143669] (1 PDB entry)
      Uniprot P64819 10-207

22. Hypothetical protein SA2161 [143674] (1 species)

    • Species Staphylococcus aureus [TaxId:1280] [143675] (1 PDB entry)
      Uniprot Q7A3W2 1-133

23. Hypothetical protein SA2309 [103173] (1 species)

    • Species Staphylococcus aureus [TaxId:1280] [103174] (2 PDB entries)

24. Hypothetical protein TTHA1254 [160640] (1 species)

    • Species Thermus thermophilus [TaxId:274] [160641] (2 PDB entries)
      Uniprot Q5SIW0 1-130

25. Hypothetical protein YqiY [90013] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [90014] (1 PDB entry)

26. Hypothetical protein YsnE [143654] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [143655] (1 PDB entry)
      Uniprot P94562 1-151

27. Hypothetical protein YvbK (BSu33890) [143706] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [143707] (1 PDB entry)
      Uniprot O32248 5-156

28. IAA acetyltransferase [143696] (1 species)
    YvbK ortholojg

    • Species Bacillus cereus [TaxId:1396] [143697] (1 PDB entry)
      Uniprot Q81FK8 1-152

29. L7/L12-Ribosomal-protein-serine acetyltransferase RimL [143678] (1 species)

    • Species Salmonella typhimurium [TaxId:90371] [143679] (5 PDB entries)
      Uniprot Q8ZPC0 1-176

30. Mycothiol synthase MshD [103175] (1 species)
    duplication: consists of two NAT domains swapped with the C-terminal strands with both domains binding acetyl-CoA; structural link with the other families

    • Species Mycobacterium tuberculosis [TaxId:1773] [103176] (3 PDB entries)
      Rv0819

31. Phosphinothricin acetyltransferase [143698] (1 species)

    • Species Agrobacterium tumefaciens [TaxId:358] [143699] (1 PDB entry)
      Uniprot Q8UGX8 2-164

32. Probable acetyltranferase Atu2435 [143704] (1 species)

    • Species Agrobacterium tumefaciens [TaxId:358] [143705] (1 PDB entry)
      Uniprot Q8UCP8 4-167

33. Probable acetyltransferase Atu2258 [143656] (1 species)

    • Species Agrobacterium tumefaciens [TaxId:358] [143657] (1 PDB entry)
      Uniprot Q7CXI0 1-137

34. Probable acetyltransferase Atu2290 [143660] (1 species)

    • Species Agrobacterium tumefaciens [TaxId:358] [143661] (1 PDB entry)
      Uniprot Q8UD38 6-169

35. Probable acetyltransferase BC2806 [143650] (1 species)

    • Species Bacillus cereus [TaxId:1396] [143651] (1 PDB entry)
      Uniprot Q81CG1 1-140

36. Probable acetyltransferase EF1919 [143662] (1 species)

    • Species Enterococcus faecalis [TaxId:1351] [143663] (1 PDB entry)
      Uniprot Q833M5 1-157

37. Probable acetyltransferase PA4026 [143692] (1 species)

    • Species Pseudomonas aeruginosa [TaxId:287] [143693] (1 PDB entry)
      Uniprot Q9HX01 1-153

38. Probable acetyltransferase SP0256 [143680] (1 species)
    probable SA2161 ortholog

    • Species Streptococcus pneumoniae [TaxId:1313] [143681] (1 PDB entry)
      Uniprot Q97SR8 1-137

39. Probable acetyltransferase TTHA1209 [118068] (1 species)

    • Species Thermus thermophilus [TaxId:274] [118069] (2 PDB entries)
      Uniprot Q5SJ05

40. Probable acetyltransferase YdaF [90015] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [90016] (1 PDB entry)

41. Probable acetyltransferase YitI [143670] (1 species)

    • Species Bacillus licheniformis [TaxId:1402] [143671] (3 PDB entries)
      Uniprot Q65LG7 2-146

42. Probable acetyltransferase YjcF [103169] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [103170] (1 PDB entry)

43. Probable histone acetyltransferase MYST1 [143672] (1 species)
    ESA1 orthologue

    • Species Human (Homo sapiens) [TaxId:9606] [143673] (1 PDB entry)
      Uniprot Q9H7Z6 178-448

44. Probable N-acetyltransferase PA0478 [143676] (1 species)

    • Species Pseudomonas aeruginosa [TaxId:287] [143677] (1 PDB entry)
      Uniprot Q9I640 3-158

45. Probable N-acetyltransferase RPA1999 [143708] (1 species)

    • Species Rhodopseudomonas palustris [TaxId:1076] [143709] (1 PDB entry)
      Uniprot Q6N8A5 2-157

46. Probable spermine/spermidine acetyltransferase EF1086 [143682] (1 species)

    • Species Enterococcus faecalis [TaxId:1351] [143683] (1 PDB entry)
      Uniprot Q836M4 1-146

47. Protease synthase and sporulation negative regulatory protein PaiA [111100] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [111101] (1 PDB entry)
      Uniprot P21340

48. Putative acetyltransferase EF0244 [143664] (1 species)

    • Species Enterococcus faecalis [TaxId:1351] [143665] (1 PDB entry)
      Uniprot Q839D1 1-161

49. Putative acetyltransferase EF0945 [118070] (1 species)

    • Species Enterococcus faecalis [TaxId:1351] [118071] (1 PDB entry)
      Uniprot Q836Z8

50. Putative acetyltransferase PA4794 [143700] (1 species)

    • Species Pseudomonas aeruginosa [TaxId:287] [143701] (1 PDB entry)
      Uniprot Q9HV14 1-160

51. Putative acetyltransferase PF0028 [118072] (1 species)

    • Species Pyrococcus furiosus [TaxId:2261] [118073] (1 PDB entry)
      Uniprot Q8U4Q2

52. Putative acetyltransferase YycN [90011] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [90012] (2 PDB entries)

53. Putative phosphinothricin acetyltransferase YwnH [103171] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [103172] (1 PDB entry)

54. Putative ribosomal-protein-serine acetyltransferase VC1889 [143684] (1 species)
    similar to RimL and RimJ

    • Species Vibrio cholerae [TaxId:666] [143685] (1 PDB entry)
      Uniprot Q9KQV9 1-178

55. Serotonin N-acetyltranferase [55746] (1 species)

    • Species Sheep (Ovis aries) [TaxId:9940] [55747] (7 PDB entries)

56. Tabtoxin resistance protein [82747] (1 species)
    possesses HAT activity

    • Species Pseudomonas syringae [TaxId:317] [82748] (2 PDB entries)

57. Transcriptional regulator BH1968 [143658] (1 species)

    • Species Bacillus halodurans [TaxId:86665] [143659] (1 PDB entry)
      Uniprot Q9KBG0 4-153

More info for Family d.108.1.1: N-acetyl transferase, NAT

Timeline for Family d.108.1.1: N-acetyl transferase, NAT:

• Family d.108.1.1: N-acetyl transferase, NAT first appeared (with stable ids) in SCOP 1.55
  
• Family d.108.1.1: N-acetyl transferase, NAT appears in SCOP 1.73
  
• Family d.108.1.1: N-acetyl transferase, NAT appears in SCOPe 2.01
  
• Family d.108.1.1: N-acetyl transferase, NAT appears in the current release, SCOPe 2.08