Lineage for Family d.108.1.1: N-acetyl transferase, NAT

  1. Root: SCOP 1.75
  2. 849709Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 870001Fold d.108: Acyl-CoA N-acyltransferases (Nat) [55728] (1 superfamily)
    3 layers: a/b/a; contains mixed beta-sheet
  4. 870002Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) [55729] (10 families) (S)
  5. 870003Family d.108.1.1: N-acetyl transferase, NAT [55730] (57 proteins)

Proteins:

  1. 870004Aminoglycoside 2'-N-acetyltransferase [75506] (1 species)
  2. 870014Aminoglycoside 3-N-acetyltransferase [55733] (1 species)
  3. 870018Aminoglycoside 6'-N-acetyltransferase [55731] (1 species)
  4. 870027Aminoglycoside N-acetyltransferase AAC(6')-IY [111098] (2 species)
    1. 870028Species Salmonella choleraesuis [TaxId:28901] [160639] (1 PDB entry)
    2. 870031Species Salmonella enteritidis [TaxId:149539] [111099] (3 PDB entries)
      Uniprot Q9R381
  5. 870037Catalytic domain of GCN5 histone acetyltransferase [55737] (3 species)
    1. 870038Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [55738] (1 PDB entry)
    2. 870041Species Human (Homo sapiens) [TaxId:9606] [143647] (1 PDB entry)
      Uniprot Q92830 497-658
    3. 870043Species Tetrahymena thermophila [TaxId:5911] [55739] (9 PDB entries)
      Uniprot Q27198 49-209
  6. 870054Diamine acetyltransferase 1 [143652] (1 species)
  7. 870074Diamine acetyltransferase 2 [143688] (1 species)
  8. 870080Glucosamine-phosphate N-acetyltransferase GNA1 [64351] (1 species)
  9. 870096Histone acetyltransferase domain of P300/CBP associating factor, PCAF [55735] (1 species)
  10. 870100Histone acetyltransferase ESA1 [55744] (1 species)
    most similar to HAT1 including the N- and C-terminal (sub)domains; the N-terminal domain contains a rudiment CCHC zinc-finger (res. 191-220); the C-terminal domain (res. 351-434) has "winged helix" DNA-binding fold
  11. 870106Histone acetyltransferase HAT1 [55742] (1 species)
    contains additional N- and C-terminal (sub)domains
  12. 870109Histone acetyltransferase HPA2 [55740] (1 species)
  13. 870119Histone acetyltransferase MYST3 [143702] (1 species)
    ESA1 orthologue
    • 870120Species Human (Homo sapiens) [TaxId:9606] [143703] (2 PDB entries)
      Uniprot Q92794 507-776
      solution structure of the zinc-binding motif have been determined in isolation (PDB 1m36, (103600))
      solution structure of the zinc-binding motif have been determined in isolation (PDB 1m36, (103600))
  14. 870123Hypothetical protein AT1g77540 [118064] (1 species)
  15. 870128Hypothetical protein MW0638 [143690] (1 species)
    SA0631 ortholog
  16. 870131Hypothetical protein PA0115 [118066] (1 species)
  17. 870141Hypothetical protein PA3270 [143686] (1 species)
  18. 870147Hypothetical protein PA4866 [143694] (1 species)
    Putative phosphinothricin acetyltransferase
  19. 870152Hypothetical protein PH0736 [143666] (1 species)
  20. 870156Hypothetical protein PH1933 [143648] (1 species)
  21. 870160Hypothetical protein Rv1347c/MT1389 [143668] (1 species)
  22. 870170Hypothetical protein SA2161 [143674] (1 species)
  23. 870174Hypothetical protein SA2309 [103173] (1 species)
  24. 870178Hypothetical protein TTHA1254 [160640] (1 species)
  25. 870182Hypothetical protein YqiY [90013] (1 species)
  26. 870186Hypothetical protein YsnE [143654] (1 species)
  27. 870189Hypothetical protein YvbK (BSu33890) [143706] (1 species)
  28. 870195IAA acetyltransferase [143696] (1 species)
    YvbK ortholojg
  29. 870201L7/L12-Ribosomal-protein-serine acetyltransferase RimL [143678] (1 species)
  30. 870212Mycothiol synthase MshD [103175] (1 species)
    duplication: consists of two NAT domains swapped with the C-terminal strands with both domains binding acetyl-CoA; structural link with the other families
  31. 870217Phosphinothricin acetyltransferase [143698] (1 species)
  32. 870223Probable acetyltranferase Atu2435 [143704] (1 species)
  33. 870226Probable acetyltransferase Atu2258 [143656] (1 species)
  34. 870229Probable acetyltransferase Atu2290 [143660] (1 species)
  35. 870235Probable acetyltransferase BC2806 [143650] (1 species)
  36. 870239Probable acetyltransferase EF1919 [143662] (1 species)
  37. 870243Probable acetyltransferase PA4026 [143692] (1 species)
  38. 870249Probable acetyltransferase SP0256 [143680] (1 species)
    probable SA2161 ortholog
  39. 870252Probable acetyltransferase TTHA1209 [118068] (1 species)
  40. 870258Probable acetyltransferase YdaF [90015] (1 species)
  41. 870266Probable acetyltransferase YitI [143670] (1 species)
  42. 870271Probable acetyltransferase YjcF [103169] (1 species)
  43. 870274Probable histone acetyltransferase MYST1 [143672] (1 species)
    ESA1 orthologue
  44. 870277Probable N-acetyltransferase PA0478 [143676] (1 species)
  45. 870281Probable N-acetyltransferase RPA1999 [143708] (1 species)
  46. 870284Probable spermine/spermidine acetyltransferase EF1086 [143682] (1 species)
  47. 870287Protease synthase and sporulation negative regulatory protein PaiA [111100] (1 species)
  48. 870291Putative acetyltransferase EF0244 [143664] (1 species)
  49. 870297Putative acetyltransferase EF0945 [118070] (1 species)
  50. 870303Putative acetyltransferase PA4794 [143700] (1 species)
  51. 870306Putative acetyltransferase PF0028 [118072] (1 species)
  52. 870310Putative acetyltransferase YycN [90011] (1 species)
  53. 870318Putative phosphinothricin acetyltransferase YwnH [103171] (1 species)
  54. 870322Putative ribosomal-protein-serine acetyltransferase VC1889 [143684] (1 species)
    similar to RimL and RimJ
  55. 870325Serotonin N-acetyltranferase [55746] (1 species)
  56. 870338Tabtoxin resistance protein [82747] (1 species)
    possesses HAT activity
  57. 870344Transcriptional regulator BH1968 [143658] (1 species)

More info for Family d.108.1.1: N-acetyl transferase, NAT

Timeline for Family d.108.1.1: N-acetyl transferase, NAT: