SCOP 1.71: Family d.108.1.1: N-acetyl transferase, NAT

Lineage for Family d.108.1.1: N-acetyl transferase, NAT

1. Root: SCOP 1.71

2. Class d: Alpha and beta proteins (a+b) [53931] (286 folds)

3. Fold d.108: Acyl-CoA N-acyltransferases (Nat) [55728] (1 superfamily)
   3 layers: a/b/a; contains mixed beta-sheet

4. Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) [55729] (5 families)

5. Family d.108.1.1: N-acetyl transferase, NAT [55730] (25 proteins)

Proteins:

1. Aminoglycoside 2'-N-acetyltransferase [75506] (1 species)

   • Species Mycobacterium tuberculosis [TaxId:1773] [75507] (4 PDB entries)

2. Aminoglycoside 3-N-acetyltransferase [55733] (1 species)

   • Species Serratia marcescens [TaxId:615] [55734] (1 PDB entry)

3. Aminoglycoside 6'-N-acetyltransferase [55731] (1 species)

   • Species Enterococcus faecium [TaxId:1352] [55732] (2 PDB entries)

4. Aminoglycoside N-acetyltransferase AAC(6')-IY [111098] (1 species)

   • Species Salmonella enteritidis [111099] (3 PDB entries)

5. Catalytic domain of GCN5 histone acetyltransferase [55737] (2 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [55738] (1 PDB entry)

   2. Species Tetrahymena thermophila [TaxId:5911] [55739] (9 PDB entries)

6. Glucosamine-phosphate N-acetyltransferase GNA1 [64351] (1 species)

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [64352] (3 PDB entries)

7. Histone acetyltransferase domain of P300/CBP associating factor, PCAF [55735] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [55736] (1 PDB entry)

8. Histone acetyltransferase ESA1 [55744] (1 species)
   most similar to HAT1 including the N- and C-terminal (sub)domains; the N-terminal domain contains a rudiment CCHC zinc-finger (res. 191-220); the C-terminal domain (res. 351-434) has "winged helix" DNA-binding fold

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [55745] (4 PDB entries)

9. Histone acetyltransferase HAT1 [55742] (1 species)
   contains additional N- and C-terminal (sub)domains

   • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [55743] (1 PDB entry)

10. Histone acetyltransferase HPA2 [55740] (1 species)

    • Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [55741] (2 PDB entries)

11. Hypothetical protein AT1g77540 [118064] (1 species)

    • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [118065] (2 PDB entries)

12. Hypothetical protein PA0115 [118066] (1 species)

    • Species Pseudomonas aeruginosa [TaxId:287] [118067] (1 PDB entry)

13. Hypothetical protein SA2309 [103173] (1 species)

    • Species Staphylococcus aureus [TaxId:1280] [103174] (1 PDB entry)

14. Hypothetical protein YqiY [90013] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [90014] (1 PDB entry)

15. Mycothiol synthase MshD [103175] (1 species)
    duplication: consists of two NAT domains swapped with the C-terminal strands with both domains binding acetyl-CoA; structural link with the other families

    • Species Mycobacterium tuberculosis [TaxId:1773] [103176] (2 PDB entries)
      Rv0819

16. Probable acetyltransferase TTHA1209 [118068] (1 species)

    • Species Thermus thermophilus [TaxId:274] [118069] (1 PDB entry)

17. Probable acetyltransferase YdaF [90015] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [90016] (1 PDB entry)

18. Probable acetyltransferase YjcF [103169] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [103170] (1 PDB entry)

19. Protease synthase and sporulation negative regulatory protein PaiA [111100] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [111101] (1 PDB entry)

20. Putative acetyltransferase EF0945 [118070] (1 species)

    • Species Enterococcus faecalis [TaxId:1351] [118071] (1 PDB entry)

21. Putative acetyltransferase PF0028 [118072] (1 species)

    • Species Pyrococcus furiosus [TaxId:186497] [118073] (1 PDB entry)

22. Putative acetyltransferase YycN [90011] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [90012] (2 PDB entries)

23. Putative phosphinothricin acetyltransferase YwnH [103171] (1 species)

    • Species Bacillus subtilis [TaxId:1423] [103172] (1 PDB entry)

24. Serotonin N-acetyltranferase [55746] (1 species)

    • Species Sheep (Ovis aries) [TaxId:9940] [55747] (7 PDB entries)

25. Tabtoxin resistance protein [82747] (1 species)
    possesses HAT activity

    • Species Pseudomonas syringae [TaxId:317] [82748] (2 PDB entries)

More info for Family d.108.1.1: N-acetyl transferase, NAT

Timeline for Family d.108.1.1: N-acetyl transferase, NAT:

• Family d.108.1.1: N-acetyl transferase, NAT first appeared (with stable ids) in SCOP 1.55
  
• Family d.108.1.1: N-acetyl transferase, NAT appears in SCOP 1.69
  
• Family d.108.1.1: N-acetyl transferase, NAT appears in SCOP 1.73
  
• Family d.108.1.1: N-acetyl transferase, NAT appears in the current release, SCOPe 2.08