Class d: Alpha and beta proteins (a+b) [53931] (385 folds) |
Fold d.108: Acyl-CoA N-acyltransferases (Nat) [55728] (1 superfamily) 3 layers: a/b/a; contains mixed beta-sheet |
Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) [55729] (11 families) |
d.108.1.1: N-acetyl transferase, NAT [55730] (58 proteins) |
d.108.1.2: N-myristoyl transferase, NMT [55748] (1 protein) duplication: consists of two NAT-like domains swapped with the C-terminal strands |
d.108.1.3: Autoinducer synthetase [75508] (2 proteins) Pfam PF00765 |
d.108.1.4: FemXAB nonribosomal peptidyltransferases [82749] (3 proteins) duplication: consists of two NAT-like domains swapped with the C-terminal strands |
d.108.1.5: Hypothetical protein cg14615-pa [103179] (1 protein) duplication: consists of two NAT-like domains swapped with the C-terminal strands |
d.108.1.6: LFTR-like [143711] (2 proteins) Pfam PF03588; closer relative to the nonribosomal peptidyltransferases (82749); deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events |
d.108.1.7: Ornithine decarboxylase antizyme-like [143714] (2 proteins) Pfam PF02100; may have evolved different function; putative active site maps to the same location in the common fold |
d.108.1.8: AstA-like [143717] (1 protein) Pfam PF04958; contains extra C-terminal domain, similar to the double psi beta-barrel fold (50684) with missing one strand and untangled psi-loops |
d.108.1.9: Aq_1966-like [143720] (1 protein) Pfam PF06557; DUF1122; probable biological unit is homotrimeric; may have evolved different function; putative active site maps to the same location in the common fold |
d.108.1.10: EF1021-like [160644] (3 proteins) duplication: consists of two NAT domains swapped with the C-terminal strands; overall structural similarity to Mycothiol synthase and N-myristoyl transferase (NMT); the similarity to NMT extends to the participation of the protein C-terminus (after the SCP2-like C-terminal domain) in the active site |
d.108.1.0: automated matches [191308] (1 protein) not a true family |
Timeline for Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat):