SCOP 1.73: Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat)

Lineage for Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat)

1. Root: SCOP 1.73

2. Class d: Alpha and beta proteins (a+b) [53931] (334 folds)

3. Fold d.108: Acyl-CoA N-acyltransferases (Nat) [55728] (1 superfamily)
   3 layers: a/b/a; contains mixed beta-sheet

4. Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) [55729] (9 families)

Families:

1. d.108.1.1: N-acetyl transferase, NAT [55730] (56 proteins)

2. d.108.1.2: N-myristoyl transferase, NMT [55748] (1 protein)
   duplication: consists of two NAT-like domains swapped with the C-terminal strands

3. d.108.1.3: Autoinducer synthetase [75508] (2 proteins)
   Pfam PF00765

4. d.108.1.4: FemXAB nonribosomal peptidyltransferases [82749] (2 proteins)
   duplication: consists of two NAT-like domains swapped with the C-terminal strands

5. d.108.1.5: Hypothetical protein cg14615-pa [103179] (1 protein)
   duplication: consists of two NAT-like domains swapped with the C-terminal strands

6. d.108.1.6: LFTR-like [143711] (1 protein)
   Pfam PF03588; closer relative to the nonribosomal peptidyltransferases (scop_fa 82749); deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events

7. d.108.1.7: Ornithine decarboxylase antizyme-like [143714] (1 protein)
   Pfam PF02100; may have evolved different function; putative active site maps to the same location in the common fold

8. d.108.1.8: AstA-like [143717] (1 protein)
   Pfam PF04958; contains extra C-terminal domain, similar to the double psi beta-barrel fold (scop_cf 50684) with missing one strand and untangled psi-loops

9. d.108.1.9: Aq 1966-like [143720] (1 protein)
   Pfam PF06557; DUF1122; probable biological unit is homotrimeric; may have evolved different function; putative active site maps to the same location in the common fold

More info for Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat)

Timeline for Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat):

• Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) first appeared (with stable ids) in SCOP 1.55
  
• Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) appears in SCOP 1.71
  
• Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) appears in SCOP 1.75
  
• Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) appears in the current release, SCOPe 2.08