Lineage for Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat)

  1. Root: SCOPe 2.08
  2. 2923792Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. 2968378Fold d.108: Acyl-CoA N-acyltransferases (Nat) [55728] (1 superfamily)
    3 layers: a/b/a; contains mixed beta-sheet
  4. 2968379Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat) [55729] (12 families) (S)

Families:

  1. 2968380d.108.1.1: N-acetyl transferase, NAT [55730] (58 proteins)
  2. 2968821d.108.1.2: N-myristoyl transferase, NMT [55748] (1 protein)
    duplication: consists of two NAT-like domains swapped with the C-terminal strands
  3. 2968867d.108.1.3: Autoinducer synthetase [75508] (2 proteins)
    Pfam PF00765
  4. 2968875d.108.1.4: FemXAB nonribosomal peptidyltransferases [82749] (3 proteins)
    duplication: consists of two NAT-like domains swapped with the C-terminal strands
  5. 2968898d.108.1.5: Hypothetical protein cg14615-pa [103179] (1 protein)
    duplication: consists of two NAT-like domains swapped with the C-terminal strands
  6. 2968902d.108.1.6: LFTR-like [143711] (2 proteins)
    Pfam PF03588; closer relative to the nonribosomal peptidyltransferases (82749); deletion of the N-terminal half of the N-terminal NAT-like domain after the domain duplication/swapping events
  7. 2968924d.108.1.7: Ornithine decarboxylase antizyme-like [143714] (2 proteins)
    Pfam PF02100; may have evolved different function; putative active site maps to the same location in the common fold
  8. 2968931d.108.1.8: AstA-like [143717] (1 protein)
    Pfam PF04958; contains extra C-terminal domain, similar to the double psi beta-barrel fold (50684) with missing one strand and untangled psi-loops
  9. 2968935d.108.1.9: Aq_1966-like [143720] (1 protein)
    Pfam PF06557; DUF1122; probable biological unit is homotrimeric; may have evolved different function; putative active site maps to the same location in the common fold
  10. 2968941d.108.1.10: EF1021-like [160644] (3 proteins)
    duplication: consists of two NAT domains swapped with the C-terminal strands; overall structural similarity to Mycothiol synthase and N-myristoyl transferase (NMT); the similarity to NMT extends to the participation of the protein C-terminus (after the SCP2-like C-terminal domain) in the active site
  11. 2968961d.108.1.11: Histone acyltransferase p300-like [418814] (1 protein)
    Pfam PF08214; adds C-terminal subdomain with extra strand and helices to common fold
  12. 2968970d.108.1.0: automated matches [191308] (1 protein)
    not a true family

More info for Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat)

Timeline for Superfamily d.108.1: Acyl-CoA N-acyltransferases (Nat):