Lineage for Protein: Urate oxidase (uricase)

  1. Root: SCOP 1.73
  2. 713694Class d: Alpha and beta proteins (a+b) [53931] (334 folds)
  3. 730177Fold d.96: T-fold [55619] (2 superfamilies)
    beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
    tunnel-shaped: its known members form wide oligomeric barrels different sizes
  4. 730178Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (4 families) (S)
    bind purine or pterin in topologically similar sites between subunits
  5. 730408Family d.96.1.4: Urate oxidase (uricase) [55633] (1 protein)
  6. 730409Protein Urate oxidase (uricase) [55634] (3 species)
    duplication: one subunit consists of two domains of this fold; beta-sheets of two subunits form a barrel, closed: n=16, S=16

Species:

  1. 730410Arthrobacter globiformis [TaxId:1665] [143630] (2 PDB entries)
    1. Domains for 1vax:
      1. 730411Domain d1vaxa1: 1vax A:142-297 [119910]
      2. 730412Domain d1vaxa2: 1vax A:11-141 [119911]
      3. 730413Domain d1vaxb1: 1vax B:142-297 [119912]
        automatically matched to 1VAX A:142-297
      4. 730414Domain d1vaxb2: 1vax B:11-141 [119913]
        automatically matched to 1VAX A:11-141
      5. 730415Domain d1vaxc1: 1vax C:142-297 [119914]
        automatically matched to 1VAX A:142-297
      6. 730416Domain d1vaxc2: 1vax C:11-141 [119915]
        automatically matched to 1VAX A:11-141
      7. 730417Domain d1vaxd1: 1vax D:142-297 [119916]
        automatically matched to 1VAX A:142-297
      8. 730418Domain d1vaxd2: 1vax D:11-141 [119917]
        automatically matched to 1VAX A:11-141
      9. 730419Domain d1vaxe1: 1vax E:142-297 [119918]
        automatically matched to 1VAX A:142-297
      10. 730420Domain d1vaxe2: 1vax E:11-141 [119919]
        automatically matched to 1VAX A:11-141
      11. 730421Domain d1vaxf1: 1vax F:142-297 [119920]
        automatically matched to 1VAX A:142-297
      12. 730422Domain d1vaxf2: 1vax F:11-141 [119921]
        automatically matched to 1VAX A:11-141
      13. 730423Domain d1vaxg1: 1vax G:142-297 [119922]
        automatically matched to 1VAX A:142-297
      14. 730424Domain d1vaxg2: 1vax G:11-141 [119923]
        automatically matched to 1VAX A:11-141
      15. 730425Domain d1vaxh1: 1vax H:142-297 [119924]
        automatically matched to 1VAX A:142-297
      16. 730426Domain d1vaxh2: 1vax H:11-141 [119925]
        automatically matched to 1VAX A:11-141
    2. Domains for 1vay:
      1. 730427Domain d1vaya1: 1vay A:142-297 [119926]
        automatically matched to 1VAX A:142-297
        complexed with aza
      2. 730428Domain d1vaya2: 1vay A:11-141 [119927]
        automatically matched to 1VAX A:11-141
        complexed with aza
      3. 730429Domain d1vayb1: 1vay B:142-297 [119928]
        automatically matched to 1VAX A:142-297
        complexed with aza
      4. 730430Domain d1vayb2: 1vay B:11-141 [119929]
        automatically matched to 1VAX A:11-141
        complexed with aza
      5. 730431Domain d1vayc1: 1vay C:142-297 [119930]
        automatically matched to 1VAX A:142-297
        complexed with aza
      6. 730432Domain d1vayc2: 1vay C:11-141 [119931]
        automatically matched to 1VAX A:11-141
        complexed with aza
      7. 730433Domain d1vayd1: 1vay D:142-297 [119932]
        automatically matched to 1VAX A:142-297
        complexed with aza
      8. 730434Domain d1vayd2: 1vay D:11-141 [119933]
        automatically matched to 1VAX A:11-141
        complexed with aza
      9. 730435Domain d1vaye1: 1vay E:142-297 [119934]
        automatically matched to 1VAX A:142-297
        complexed with aza
      10. 730436Domain d1vaye2: 1vay E:11-141 [119935]
        automatically matched to 1VAX A:11-141
        complexed with aza
      11. 730437Domain d1vayf1: 1vay F:142-297 [119936]
        automatically matched to 1VAX A:142-297
        complexed with aza
      12. 730438Domain d1vayf2: 1vay F:11-141 [119937]
        automatically matched to 1VAX A:11-141
        complexed with aza
      13. 730439Domain d1vayg1: 1vay G:142-297 [119938]
        automatically matched to 1VAX A:142-297
        complexed with aza
      14. 730440Domain d1vayg2: 1vay G:11-141 [119939]
        automatically matched to 1VAX A:11-141
        complexed with aza
      15. 730441Domain d1vayh1: 1vay H:142-297 [119940]
        automatically matched to 1VAX A:142-297
        complexed with aza
      16. 730442Domain d1vayh2: 1vay H:11-141 [119941]
        automatically matched to 1VAX A:11-141
        complexed with aza
  2. 730443Aspergillus flavus [TaxId:5059] [55635] (15 PDB entries)
    1. Domains for 1r4s:
      1. 730458Domain d1r4sa1: 1r4s A:1-136 [97045]
      2. 730459Domain d1r4sa2: 1r4s A:137-296 [97046]
        complexed with fcy, mua
    2. Domains for 1r4u:
      1. 730454Domain d1r4ua1: 1r4u A:1-136 [97047]
      2. 730455Domain d1r4ua2: 1r4u A:137-295 [97048]
        complexed with oxc
    3. Domains for 1r51:
      1. 730452Domain d1r51a1: 1r51 A:1-136 [97057]
      2. 730453Domain d1r51a2: 1r51 A:137-296 [97058]
        complexed with aza, fcy
    4. Domains for 1r56:
      1. 730464Domain d1r56a1: 1r56 A:1-136 [97064]
      2. 730465Domain d1r56a2: 1r56 A:137-295 [97065]
      3. 730466Domain d1r56b1: 1r56 B:1-136 [97066]
      4. 730467Domain d1r56b2: 1r56 B:137-295 [97067]
      5. 730468Domain d1r56c1: 1r56 C:1-136 [97068]
      6. 730469Domain d1r56c2: 1r56 C:137-299 [97069]
      7. 730470Domain d1r56d1: 1r56 D:1-136 [97070]
      8. 730471Domain d1r56d2: 1r56 D:137-295 [97071]
      9. 730472Domain d1r56e1: 1r56 E:1-136 [97072]
      10. 730473Domain d1r56e2: 1r56 E:137-295 [97073]
      11. 730474Domain d1r56f1: 1r56 F:1-136 [97074]
      12. 730475Domain d1r56f2: 1r56 F:137-295 [97075]
      13. 730476Domain d1r56g1: 1r56 G:1-136 [97076]
      14. 730477Domain d1r56g2: 1r56 G:137-296 [97077]
      15. 730478Domain d1r56h1: 1r56 H:1-136 [97078]
      16. 730479Domain d1r56h2: 1r56 H:137-295 [97079]
        complexed with peg
    5. Domains for 1wrr:
      1. 730446Domain d1wrra1: 1wrr A:1-136 [121204]
        automatically matched to d1r4sa1
        complexed with unc
      2. 730447Domain d1wrra2: 1wrr A:137-295 [121205]
        automatically matched to d1r56c2
        complexed with unc
    6. Domains for 1ws2:
      1. 730480Domain d1ws2a1: 1ws2 A:1-136 [121206]
        automatically matched to d1r4sa1
        complexed with urn
      2. 730481Domain d1ws2a2: 1ws2 A:137-295 [121207]
        automatically matched to d1r56c2
        complexed with urn
      3. 730482Domain d1ws2b1: 1ws2 B:1-136 [121208]
        automatically matched to d1r4sa1
        complexed with urn
      4. 730483Domain d1ws2b2: 1ws2 B:137-295 [121209]
        automatically matched to d1r56c2
        complexed with urn
      5. 730484Domain d1ws2c1: 1ws2 C:1-136 [121210]
        automatically matched to d1r4sa1
        complexed with urn
      6. 730485Domain d1ws2c2: 1ws2 C:137-295 [121211]
        automatically matched to d1r56c2
        complexed with urn
      7. 730486Domain d1ws2d1: 1ws2 D:1-136 [121212]
        automatically matched to d1r4sa1
        complexed with urn
      8. 730487Domain d1ws2d2: 1ws2 D:137-295 [121213]
        automatically matched to d1r56c2
        complexed with urn
    7. Domains for 1ws3:
      1. 730496Domain d1ws3a1: 1ws3 A:1-136 [121214]
        automatically matched to d1r4sa1
        complexed with ura
      2. 730497Domain d1ws3a2: 1ws3 A:137-295 [121215]
        automatically matched to d1r56c2
        complexed with ura
      3. 730498Domain d1ws3b1: 1ws3 B:1-136 [121216]
        automatically matched to d1r4sa1
        complexed with ura
      4. 730499Domain d1ws3b2: 1ws3 B:137-295 [121217]
        automatically matched to d1r56c2
        complexed with ura
      5. 730500Domain d1ws3c1: 1ws3 C:1-136 [121218]
        automatically matched to d1r4sa1
        complexed with ura
      6. 730501Domain d1ws3c2: 1ws3 C:137-295 [121219]
        automatically matched to d1r56c2
        complexed with ura
      7. 730502Domain d1ws3d1: 1ws3 D:1-136 [121220]
        automatically matched to d1r4sa1
        complexed with ura
      8. 730503Domain d1ws3d2: 1ws3 D:137-295 [121221]
        automatically matched to d1r56c2
        complexed with ura
    8. Domains for 1xt4:
      1. 730462Domain d1xt4a1: 1xt4 A:1-136 [122291]
        automatically matched to d1r4sa1
        complexed with gun
      2. 730463Domain d1xt4a2: 1xt4 A:137-295 [122292]
        automatically matched to d1r56c2
        complexed with gun
    9. Domains for 1xxj:
      1. 730488Domain d1xxja1: 1xxj A:1-136 [122414]
        automatically matched to d1r4sa1
        complexed with bnz, unc
      2. 730489Domain d1xxja2: 1xxj A:137-295 [122415]
        automatically matched to d1r56c2
        complexed with bnz, unc
      3. 730490Domain d1xxjb1: 1xxj B:1-136 [122416]
        automatically matched to d1r4sa1
        complexed with bnz, unc
      4. 730491Domain d1xxjb2: 1xxj B:137-295 [122417]
        automatically matched to d1r56c2
        complexed with bnz, unc
      5. 730492Domain d1xxjc1: 1xxj C:1-136 [122418]
        automatically matched to d1r4sa1
        complexed with bnz, unc
      6. 730493Domain d1xxjc2: 1xxj C:137-295 [122419]
        automatically matched to d1r56c2
        complexed with bnz, unc
      7. 730494Domain d1xxjd1: 1xxj D:1-136 [122420]
        automatically matched to d1r4sa1
        complexed with bnz, unc
      8. 730495Domain d1xxjd2: 1xxj D:137-295 [122421]
        automatically matched to d1r56c2
        complexed with bnz, unc
    10. Domains for 1xy3:
      1. 730504Domain d1xy3a1: 1xy3 A:1-136 [122441]
        automatically matched to d1r4sa1
        complexed with gun
      2. 730505Domain d1xy3a2: 1xy3 A:137-295 [122442]
        automatically matched to d1r56c2
        complexed with gun
      3. 730506Domain d1xy3b1: 1xy3 B:1-136 [122443]
        automatically matched to d1r4sa1
        complexed with gun
      4. 730507Domain d1xy3b2: 1xy3 B:137-295 [122444]
        automatically matched to d1r56c2
        complexed with gun
      5. 730508Domain d1xy3c1: 1xy3 C:1-136 [122445]
        automatically matched to d1r4sa1
        complexed with gun
      6. 730509Domain d1xy3c2: 1xy3 C:137-295 [122446]
        automatically matched to d1r56c2
        complexed with gun
      7. 730510Domain d1xy3d1: 1xy3 D:1-136 [122447]
        automatically matched to d1r4sa1
        complexed with gun
      8. 730511Domain d1xy3d2: 1xy3 D:137-295 [122448]
        automatically matched to d1r56c2
        complexed with gun
      9. 730512Domain d1xy3e1: 1xy3 E:1-136 [122449]
        automatically matched to d1r4sa1
        complexed with gun
      10. 730513Domain d1xy3e2: 1xy3 E:137-295 [122450]
        automatically matched to d1r56c2
        complexed with gun
      11. 730514Domain d1xy3f1: 1xy3 F:1-136 [122451]
        automatically matched to d1r4sa1
        complexed with gun
      12. 730515Domain d1xy3f2: 1xy3 F:137-295 [122452]
        automatically matched to d1r56c2
        complexed with gun
      13. 730516Domain d1xy3g1: 1xy3 G:1-136 [122453]
        automatically matched to d1r4sa1
        complexed with gun
      14. 730517Domain d1xy3g2: 1xy3 G:137-295 [122454]
        automatically matched to d1r56c2
        complexed with gun
      15. 730518Domain d1xy3h1: 1xy3 H:1-136 [122455]
        automatically matched to d1r4sa1
        complexed with gun
      16. 730519Domain d1xy3h2: 1xy3 H:137-295 [122456]
        automatically matched to d1r56c2
        complexed with gun
    11. Domains for 2fub:
      1. 730460Domain d2fuba1: 2fub A:1-136 [134114]
        automatically matched to d1r4sa1
        complexed with aza, cys
      2. 730461Domain d2fuba2: 2fub A:137-295 [134115]
        automatically matched to d1r56c2
        complexed with aza, cys
    12. Domains for 2fxl:
      1. 730456Domain d2fxla1: 2fxl A:1-136 [134325]
        automatically matched to d1r4sa1
        complexed with 2al
      2. 730457Domain d2fxla2: 2fxl A:137-295 [134326]
        automatically matched to d1r56c2
        complexed with 2al
    13. Domains for 2iba:
      1. 730444Domain d2ibaa1: 2iba A:1-136 [137178]
        automatically matched to d1r4sa1
        complexed with ace, aza, na
      2. 730445Domain d2ibaa2: 2iba A:137-295 [137179]
        automatically matched to d1r56c2
        complexed with ace, aza, na
    14. Domains for 2ic0:
      1. 730450Domain d2ic0a1: 2ic0 A:1-136 [137231]
        automatically matched to d1r4sa1
        complexed with ace, aza, na, xe
      2. 730451Domain d2ic0a2: 2ic0 A:137-295 [137232]
        automatically matched to d1r56c2
        complexed with ace, aza, na, xe
    15. Domains for 2icq:
      1. 730448Domain d2icqa1: 2icq A:1-136 [137239]
        automatically matched to d1r4sa1
        complexed with ace, aza, cys, n2o
      2. 730449Domain d2icqa2: 2icq A:137-295 [137240]
        automatically matched to d1r56c2
        complexed with ace, aza, cys, n2o
  3. 730520Bacillus sp., strain TB-90 [TaxId:1409] [111089] (1 PDB entry)

More info for Protein Urate oxidase (uricase) from d.96.1.4: Urate oxidase (uricase)

Timeline for Protein Urate oxidase (uricase) from d.96.1.4: Urate oxidase (uricase):