SCOPe 2.07: Family d.96.1.4: Urate oxidase (uricase)

Lineage for Family d.96.1.4: Urate oxidase (uricase)

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.96: T-fold [55619] (2 superfamilies)
   beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
   tunnel-shaped: its known members form wide oligomeric barrels different sizes

4. Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (5 families)
   bind purine or pterin in topologically similar sites between subunits

5. Family d.96.1.4: Urate oxidase (uricase) [55633] (2 proteins)
   automatically mapped to Pfam PF01014

Proteins:

1. Urate oxidase (uricase) [55634] (3 species)
   duplication: one subunit consists of two domains of this fold; beta-sheets of two subunits form a barrel, closed: n=16, S=16

   1. Species Arthrobacter globiformis [TaxId:1665] [143630] (2 PDB entries)

   2. Species Aspergillus flavus [TaxId:5059] [55635] (71 PDB entries)

   3. Species Bacillus sp., strain TB-90 [TaxId:1409] [111089] (1 PDB entry)
      Uniprot Q45697 177-482

2. automated matches [254656] (4 species)
   not a true protein

   1. Species Arthrobacter globiformis [TaxId:1665] [255720] (5 PDB entries)

   2. Species Aspergillus flavus [TaxId:5059] [260668] (5 PDB entries)

   3. Species Bacillus sp. [TaxId:36824] [312567] (14 PDB entries)

   4. Species Bacillus tb-90 [TaxId:36824] [280497] (1 PDB entry)

More info for Family d.96.1.4: Urate oxidase (uricase)

Timeline for Family d.96.1.4: Urate oxidase (uricase):

• Family d.96.1.4: Urate oxidase (uricase) first appeared (with stable ids) in SCOP 1.55
  
• Family d.96.1.4: Urate oxidase (uricase) appears in SCOPe 2.06
  
• Family d.96.1.4: Urate oxidase (uricase) appears in the current release, SCOPe 2.08