Lineage for Protein: GTP cyclohydrolase I

  1. Root: SCOPe 2.08
  2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)
  3. Fold d.96: T-fold [55619] (2 superfamilies)
    beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
    tunnel-shaped: its known members form wide oligomeric barrels different sizes
  4. Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (5 families) (S)
    bind purine or pterin in topologically similar sites between subunits
  5. Family d.96.1.1: GTP cyclohydrolase I [55621] (2 proteins)
  6. Protein GTP cyclohydrolase I [55622] (4 species)
    beta-sheets of five subunits form a barrel, closed: n=20, S=20

Species:

  1. Escherichia coli [TaxId:562] [55623] (7 PDB entries)
    1. Domains for 1a8r:
      1. Domain d1a8ra_: 1a8r A: [40587]
        complexed with gtp; mutant
      2. Domain d1a8rb_: 1a8r B: [40588]
        complexed with gtp; mutant
      3. Domain d1a8rc_: 1a8r C: [40589]
        complexed with gtp; mutant
      4. Domain d1a8rd_: 1a8r D: [40590]
        complexed with gtp; mutant
      5. Domain d1a8re_: 1a8r E: [40591]
        complexed with gtp; mutant
      6. Domain d1a8rf_: 1a8r F: [40592]
        complexed with gtp; mutant
      7. Domain d1a8rg_: 1a8r G: [40593]
        complexed with gtp; mutant
      8. Domain d1a8rh_: 1a8r H: [40594]
        complexed with gtp; mutant
      9. Domain d1a8ri_: 1a8r I: [40595]
        complexed with gtp; mutant
      10. Domain d1a8rj_: 1a8r J: [40596]
        complexed with gtp; mutant
      11. Domain d1a8rk_: 1a8r K: [40597]
        complexed with gtp; mutant
      12. Domain d1a8rl_: 1a8r L: [40598]
        complexed with gtp; mutant
      13. Domain d1a8rm_: 1a8r M: [40599]
        complexed with gtp; mutant
      14. Domain d1a8rn_: 1a8r N: [40600]
        complexed with gtp; mutant
      15. Domain d1a8ro_: 1a8r O: [40601]
        complexed with gtp; mutant
    2. Domains for 1a9c:
      1. Domain d1a9ca_: 1a9c A: [40602]
        complexed with gtp; mutant
      2. Domain d1a9cb_: 1a9c B: [40603]
        complexed with gtp; mutant
      3. Domain d1a9cc_: 1a9c C: [40604]
        complexed with gtp; mutant
      4. Domain d1a9cd_: 1a9c D: [40605]
        complexed with gtp; mutant
      5. Domain d1a9ce_: 1a9c E: [40606]
        complexed with gtp; mutant
      6. Domain d1a9cf_: 1a9c F: [40607]
        complexed with gtp; mutant
      7. Domain d1a9cg_: 1a9c G: [40608]
        complexed with gtp; mutant
      8. Domain d1a9ch_: 1a9c H: [40609]
        complexed with gtp; mutant
      9. Domain d1a9ci_: 1a9c I: [40610]
        complexed with gtp; mutant
      10. Domain d1a9cj_: 1a9c J: [40611]
        complexed with gtp; mutant
      11. Domain d1a9ck_: 1a9c K: [40612]
        complexed with gtp; mutant
      12. Domain d1a9cl_: 1a9c L: [40613]
        complexed with gtp; mutant
      13. Domain d1a9cm_: 1a9c M: [40614]
        complexed with gtp; mutant
      14. Domain d1a9cn_: 1a9c N: [40615]
        complexed with gtp; mutant
      15. Domain d1a9co_: 1a9c O: [40616]
        complexed with gtp; mutant
    3. Domains for 1fbx:
      1. Domain d1fbxa_: 1fbx A: [40617]
        zinc-containing active form
        complexed with cl, zn
      2. Domain d1fbxb_: 1fbx B: [40618]
        zinc-containing active form
        complexed with cl, zn
      3. Domain d1fbxc_: 1fbx C: [40619]
        zinc-containing active form
        complexed with cl, zn
      4. Domain d1fbxd_: 1fbx D: [40620]
        zinc-containing active form
        complexed with cl, zn
      5. Domain d1fbxe_: 1fbx E: [40621]
        zinc-containing active form
        complexed with cl, zn
      6. Domain d1fbxf_: 1fbx F: [40622]
        zinc-containing active form
        complexed with cl, zn
      7. Domain d1fbxg_: 1fbx G: [40623]
        zinc-containing active form
        complexed with cl, zn
      8. Domain d1fbxh_: 1fbx H: [40624]
        zinc-containing active form
        complexed with cl, zn
      9. Domain d1fbxi_: 1fbx I: [40625]
        zinc-containing active form
        complexed with cl, zn
      10. Domain d1fbxj_: 1fbx J: [40626]
        zinc-containing active form
        complexed with cl, zn
      11. Domain d1fbxk_: 1fbx K: [40627]
        zinc-containing active form
        complexed with cl, zn
      12. Domain d1fbxl_: 1fbx L: [40628]
        zinc-containing active form
        complexed with cl, zn
      13. Domain d1fbxm_: 1fbx M: [40629]
        zinc-containing active form
        complexed with cl, zn
      14. Domain d1fbxn_: 1fbx N: [40630]
        zinc-containing active form
        complexed with cl, zn
      15. Domain d1fbxo_: 1fbx O: [40631]
        zinc-containing active form
        complexed with cl, zn
    4. Domains for 1gtp:
      1. Domain d1gtpa_: 1gtp A: [40632]
        complexed with so4
      2. Domain d1gtpb_: 1gtp B: [40633]
        complexed with so4
      3. Domain d1gtpc_: 1gtp C: [40634]
        complexed with so4
      4. Domain d1gtpd_: 1gtp D: [40635]
        complexed with so4
      5. Domain d1gtpe_: 1gtp E: [40636]
        complexed with so4
      6. Domain d1gtpf_: 1gtp F: [40637]
        complexed with so4
      7. Domain d1gtpg_: 1gtp G: [40638]
        complexed with so4
      8. Domain d1gtph_: 1gtp H: [40639]
        complexed with so4
      9. Domain d1gtpi_: 1gtp I: [40640]
        complexed with so4
      10. Domain d1gtpj_: 1gtp J: [40641]
        complexed with so4
      11. Domain d1gtpk_: 1gtp K: [40642]
        complexed with so4
      12. Domain d1gtpl_: 1gtp L: [40643]
        complexed with so4
      13. Domain d1gtpm_: 1gtp M: [40644]
        complexed with so4
      14. Domain d1gtpn_: 1gtp N: [40645]
        complexed with so4
      15. Domain d1gtpo_: 1gtp O: [40646]
        complexed with so4
      16. Domain d1gtpp_: 1gtp P: [40647]
        complexed with so4
      17. Domain d1gtpq_: 1gtp Q: [40648]
        complexed with so4
      18. Domain d1gtpr_: 1gtp R: [40649]
        complexed with so4
      19. Domain d1gtps_: 1gtp S: [40650]
        complexed with so4
      20. Domain d1gtpt_: 1gtp T: [40651]
        complexed with so4
    5. Domains for 1n3r:
      1. Domain d1n3ra_: 1n3r A: [91568]
        complexed with gtp
      2. Domain d1n3rb_: 1n3r B: [91569]
        complexed with gtp
      3. Domain d1n3rc_: 1n3r C: [91570]
        complexed with gtp
      4. Domain d1n3rd_: 1n3r D: [91571]
        complexed with gtp
      5. Domain d1n3re_: 1n3r E: [91572]
        complexed with gtp
      6. Domain d1n3rf_: 1n3r F: [91573]
        complexed with gtp
      7. Domain d1n3rg_: 1n3r G: [91574]
        complexed with gtp
      8. Domain d1n3rh_: 1n3r H: [91575]
        complexed with gtp
      9. Domain d1n3ri_: 1n3r I: [91576]
        complexed with gtp
      10. Domain d1n3rj_: 1n3r J: [91577]
        complexed with gtp
      11. Domain d1n3rk_: 1n3r K: [91578]
        complexed with gtp
      12. Domain d1n3rl_: 1n3r L: [91579]
        complexed with gtp
      13. Domain d1n3rm_: 1n3r M: [91580]
        complexed with gtp
      14. Domain d1n3rn_: 1n3r N: [91581]
        complexed with gtp
      15. Domain d1n3ro_: 1n3r O: [91582]
        complexed with gtp
    6. Domains for 1n3s:
      1. Domain d1n3sa_: 1n3s A: [91583]
        complexed with gtp
      2. Domain d1n3sb_: 1n3s B: [91584]
        complexed with gtp
      3. Domain d1n3sc_: 1n3s C: [91585]
        complexed with gtp
      4. Domain d1n3sd_: 1n3s D: [91586]
        complexed with gtp
      5. Domain d1n3se_: 1n3s E: [91587]
        complexed with gtp
      6. Domain d1n3sf_: 1n3s F: [91588]
        complexed with gtp
      7. Domain d1n3sg_: 1n3s G: [91589]
        complexed with gtp
      8. Domain d1n3sh_: 1n3s H: [91590]
        complexed with gtp
      9. Domain d1n3si_: 1n3s I: [91591]
        complexed with gtp
      10. Domain d1n3sj_: 1n3s J: [91592]
        complexed with gtp
    7. Domains for 1n3t:
      1. Domain d1n3ta_: 1n3t A: [91593]
        complexed with gtp
      2. Domain d1n3tb_: 1n3t B: [91594]
        complexed with gtp
      3. Domain d1n3tc_: 1n3t C: [91595]
        complexed with gtp
      4. Domain d1n3td_: 1n3t D: [91596]
        complexed with gtp
      5. Domain d1n3te_: 1n3t E: [91597]
        complexed with gtp
      6. Domain d1n3tf_: 1n3t F: [91598]
        complexed with gtp
      7. Domain d1n3tg_: 1n3t G: [91599]
        complexed with gtp
      8. Domain d1n3th_: 1n3t H: [91600]
        complexed with gtp
      9. Domain d1n3ti_: 1n3t I: [91601]
        complexed with gtp
      10. Domain d1n3tj_: 1n3t J: [91602]
        complexed with gtp
      11. Domain d1n3tk_: 1n3t K: [91603]
        complexed with gtp
      12. Domain d1n3tl_: 1n3t L: [91604]
        complexed with gtp
      13. Domain d1n3tm_: 1n3t M: [91605]
        complexed with gtp
      14. Domain d1n3tn_: 1n3t N: [91606]
        complexed with gtp
      15. Domain d1n3to_: 1n3t O: [91607]
        complexed with gtp
  2. Human (Homo sapiens) [TaxId:9606] [55624] (1 PDB entry)
  3. Norway rat (Rattus norvegicus) [TaxId:10116] [69790] (3 PDB entries)
    Uniprot P22288
    1. Domains for 1is7:
      1. Domain d1is7a_: 1is7 A: [66301]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
      2. Domain d1is7b_: 1is7 B: [66302]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
      3. Domain d1is7c_: 1is7 C: [66303]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
      4. Domain d1is7d_: 1is7 D: [66304]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
      5. Domain d1is7e_: 1is7 E: [66305]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
      6. Domain d1is7f_: 1is7 F: [66306]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
      7. Domain d1is7g_: 1is7 G: [66307]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
      8. Domain d1is7h_: 1is7 H: [66308]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
      9. Domain d1is7i_: 1is7 I: [66309]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
      10. Domain d1is7j_: 1is7 J: [66310]
        Other proteins in same PDB: d1is7k_, d1is7l_, d1is7m_, d1is7n_, d1is7o_, d1is7p_, d1is7q_, d1is7r_, d1is7s_, d1is7t_
        complexed with k, phe
    2. Domains for 1is8:
      1. Domain d1is8a_: 1is8 A: [66321]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
      2. Domain d1is8b_: 1is8 B: [66322]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
      3. Domain d1is8c_: 1is8 C: [66323]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
      4. Domain d1is8d_: 1is8 D: [66324]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
      5. Domain d1is8e_: 1is8 E: [66325]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
      6. Domain d1is8f_: 1is8 F: [66326]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
      7. Domain d1is8g_: 1is8 G: [66327]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
      8. Domain d1is8h_: 1is8 H: [66328]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
      9. Domain d1is8i_: 1is8 I: [66329]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
      10. Domain d1is8j_: 1is8 J: [66330]
        Other proteins in same PDB: d1is8k_, d1is8l_, d1is8m_, d1is8n_, d1is8o_, d1is8p_, d1is8q_, d1is8r_, d1is8s_, d1is8t_
        complexed with k, phe, zn
    3. Domains for 1wpl:
      1. Domain d1wpla_: 1wpl A: [109472]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
      2. Domain d1wplb_: 1wpl B: [109473]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
      3. Domain d1wplc_: 1wpl C: [109474]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
      4. Domain d1wpld_: 1wpl D: [109475]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
      5. Domain d1wple_: 1wpl E: [109476]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
      6. Domain d1wplf_: 1wpl F: [109477]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
      7. Domain d1wplg_: 1wpl G: [109478]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
      8. Domain d1wplh_: 1wpl H: [109479]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
      9. Domain d1wpli_: 1wpl I: [109480]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
      10. Domain d1wplj_: 1wpl J: [109481]
        Other proteins in same PDB: d1wplk_, d1wpll_, d1wplm_, d1wpln_, d1wplo_, d1wplp_, d1wplq_, d1wplr_, d1wpls_, d1wplt_
        complexed with 3po, hbi, na, zn
  4. Thermus thermophilus [TaxId:274] [143627] (3 PDB entries)
    Uniprot Q5SH52 32-216
    1. Domains for 1wm9:
      1. Domain d1wm9a1: 1wm9 A:32-216 [121037]
        complexed with zn
      2. Domain d1wm9b_: 1wm9 B: [121038]
        automated match to d1wm9a1
        complexed with zn
      3. Domain d1wm9c_: 1wm9 C: [121039]
        automated match to d1wm9a1
        complexed with zn
      4. Domain d1wm9d_: 1wm9 D: [121040]
        automated match to d1wm9a1
        complexed with zn
      5. Domain d1wm9e_: 1wm9 E: [121041]
        automated match to d1wm9a1
        complexed with zn
    2. Domains for 1wuq:
      1. Domain d1wuqa_: 1wuq A: [121304]
        automated match to d1wm9a1
        complexed with 8gt, zn
      2. Domain d1wuqb_: 1wuq B: [121305]
        automated match to d1wm9a1
        complexed with 8gt, zn
      3. Domain d1wuqc_: 1wuq C: [121306]
        automated match to d1wm9a1
        complexed with 8gt, zn
      4. Domain d1wuqd_: 1wuq D: [121307]
        automated match to d1wm9a1
        complexed with 8gt, zn
      5. Domain d1wuqe_: 1wuq E: [121308]
        automated match to d1wm9a1
        complexed with 8gt, zn
    3. Domains for 1wur:
      1. Domain d1wura_: 1wur A: [121309]
        automated match to d1wm9a1
        complexed with 8dg, zn
      2. Domain d1wurb_: 1wur B: [121310]
        automated match to d1wm9a1
        complexed with 8dg, zn
      3. Domain d1wurc_: 1wur C: [121311]
        automated match to d1wm9a1
        complexed with 8dg, zn
      4. Domain d1wurd_: 1wur D: [121312]
        automated match to d1wm9a1
        complexed with 8dg, zn
      5. Domain d1wure_: 1wur E: [121313]
        automated match to d1wm9a1
        complexed with 8dg, zn

More info for Protein GTP cyclohydrolase I from d.96.1.1: GTP cyclohydrolase I

Timeline for Protein GTP cyclohydrolase I from d.96.1.1: GTP cyclohydrolase I: