SCOPe 2.07: Family d.96.1.1: GTP cyclohydrolase I

Lineage for Family d.96.1.1: GTP cyclohydrolase I

1. Root: SCOPe 2.07

2. Class d: Alpha and beta proteins (a+b) [53931] (388 folds)

3. Fold d.96: T-fold [55619] (2 superfamilies)
   beta(2)-alpha(2)-beta(2); 2 layers: alpha/beta; antiparallel sheet 1234
   tunnel-shaped: its known members form wide oligomeric barrels different sizes

4. Superfamily d.96.1: Tetrahydrobiopterin biosynthesis enzymes-like [55620] (5 families)
   bind purine or pterin in topologically similar sites between subunits

5. Family d.96.1.1: GTP cyclohydrolase I [55621] (2 proteins)

Proteins:

1. GTP cyclohydrolase I [55622] (4 species)
   beta-sheets of five subunits form a barrel, closed: n=20, S=20

   1. Species Escherichia coli [TaxId:562] [55623] (7 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [55624] (1 PDB entry)

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [69790] (3 PDB entries)
      Uniprot P22288

   4. Species Thermus thermophilus [TaxId:274] [143627] (3 PDB entries)
      Uniprot Q5SH52 32-216

2. automated matches [195794] (2 species)
   not a true protein

   1. Species Homo sapiens [TaxId:9606] [396510] (6 PDB entries)

   2. Species Yersinia pseudotuberculosis [TaxId:214092] [195796] (1 PDB entry)

More info for Family d.96.1.1: GTP cyclohydrolase I

Timeline for Family d.96.1.1: GTP cyclohydrolase I:

• Family d.96.1.1: GTP cyclohydrolase I first appeared (with stable ids) in SCOP 1.55
  
• Family d.96.1.1: GTP cyclohydrolase I appears in SCOPe 2.06
  
• Family d.96.1.1: GTP cyclohydrolase I appears in the current release, SCOPe 2.08