SCOPe 2.05: Family d.93.1.1: SH2 domain

Lineage for Family d.93.1.1: SH2 domain

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flanked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (2 families)

5. Family d.93.1.1: SH2 domain [55551] (35 proteins)
   Pfam PF00017

Proteins:

1. Abl tyrosine kinase [55581] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [55582] (2 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [89998] (1 PDB entry)

2. Adaptor protein Aps [103139] (1 species)

   • Species Norway rat (Rattus norvegicus) [TaxId:10116] [103140] (2 PDB entries)

3. Beta-chimaerin, N-terminal domain [118052] (1 species)
   includes N-terminal tail and the linker to the next domain

   • Species Human (Homo sapiens) [TaxId:9606] [118053] (1 PDB entry)
     Uniprot P52757 23-468

4. c-src tyrosine kinase [55556] (3 species)

   1. Species Chicken (Gallus gallus) [TaxId:9031] [55558] (4 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [55557] (46 PDB entries)

   3. Species Rous sarcoma virus [TaxId:11886] [69782] (12 PDB entries)

5. Carboxyl-terminal src kinase (csk) [75498] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75499] (1 PDB entry)

6. Cbl [55587] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [55588] (10 PDB entries)

7. Crk proto-oncogen [82741] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [82742] (2 PDB entries)

8. Csk homologous kinase Chk [64345] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [64346] (2 PDB entries)

9. Ews/fli1 activated transcript 2, Eat2 [89999] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [90000] (1 PDB entry)

10. GRB2-related adaptor protein 2 (MONA, GRID) [111086] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [111087] (3 PDB entries)
      Uniprot O89100 53-147

11. Growth factor receptor-bound protein 10, GRB10 [89994] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89995] (1 PDB entry)

12. Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55564] (34 PDB entries)

13. Growth factor receptor-bound protein 7 [103135] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [103136] (4 PDB entries)

14. Hematopoietic SH2 domain containing protein HSH2D [143623] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [143624] (1 PDB entry)
      Uniprot Q96JZ2 24-129

15. Hemopoetic cell kinase Hck [55565] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55566] (18 PDB entries)

16. Itk/tsk protein tyrosine kinase [82743] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [82744] (8 PDB entries)

17. P55 Blk protein tyrosine kinase [55579] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [55580] (2 PDB entries)

18. p56-lck tyrosine kinase [55552] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55553] (11 PDB entries)

19. Phosphatidylinositol 3-kinase, p85-alpha subunit [55569] (3 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [55570] (7 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [55571] (2 PDB entries)

    3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [55572] (2 PDB entries)

20. Phospholipase C-gamma-1 [55577] (2 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [55578] (3 PDB entries)

    2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [226824] (2 PDB entries)

21. Proto-oncogen tyrosine kinase [55573] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55574] (2 PDB entries)

22. Shc adaptor protein [55567] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55568] (2 PDB entries)

23. STAT homologue [103137] (1 species)

    • Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [103138] (2 PDB entries)

24. STAT-1 [55583] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55584] (1 PDB entry)

25. STAT3b [55585] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [55586] (1 PDB entry)

26. Suppressor of cytokine signaling 2, SOCS-2 [160562] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [160563] (2 PDB entries)
      Uniprot O14508 32-134

27. Suppressor of cytokine signaling 4, SOCS-4 [160564] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [160565] (1 PDB entry)
      Uniprot Q8WXH5 274-385

28. Syk tyrosine kinase [55575] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55576] (3 PDB entries)

29. The Xlp protein Sap [55591] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55592] (6 PDB entries)

30. Tyrosine kinase Fyn [55559] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55560] (5 PDB entries)

31. Tyrosine phoshatase shp-2 [55589] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55590] (1 PDB entry)

32. Tyrosine phosphatase Syp [55561] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [55562] (4 PDB entries)

33. Tyrosine-protein kinase 6 (Breast tumor kinase, Brk) [111084] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [111085] (1 PDB entry)
      Uniprot Q13882 75-174

34. Tyrosine-protein kinase zap-70 [89996] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89997] (2 PDB entries)

35. automated matches [190202] (2 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [186949] (13 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [187800] (5 PDB entries)

More info for Family d.93.1.1: SH2 domain

Timeline for Family d.93.1.1: SH2 domain:

• Family d.93.1.1: SH2 domain first appeared (with stable ids) in SCOP 1.55
  
• Family d.93.1.1: SH2 domain appears in SCOPe 2.04
  
• Family d.93.1.1: SH2 domain appears in SCOPe 2.06
  
• Family d.93.1.1: SH2 domain appears in the current release, SCOPe 2.08