SCOP 1.69: Family d.93.1.1: SH2 domain

Lineage for Family d.93.1.1: SH2 domain

1. Root: SCOP 1.69

2. Class d: Alpha and beta proteins (a+b) [53931] (279 folds)

3. Fold d.93: SH2-like [55549] (1 superfamily)
   3 layers: a/b/a; antiparallel beta-sheet of 5 strands is flaked by two helices

4. Superfamily d.93.1: SH2 domain [55550] (1 family)

5. Family d.93.1.1: SH2 domain [55551] (30 proteins)
   Pfam 00017

Proteins:

1. Abl tyrosine kinase [55581] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [55582] (1 PDB entry)

   2. Species Mouse (Mus musculus) [TaxId:10090] [89998] (2 PDB entries)

2. Adaptor protein Aps [103139] (1 species)

   • Species Rat (Rattus norvegicus) [TaxId:10116] [103140] (2 PDB entries)

3. c-src tyrosine kinase [55556] (3 species)

   1. Species Chicken (Gallus gallus) [TaxId:9031] [55558] (3 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [55557] (40 PDB entries)

   3. Species Rous sarcoma virus [TaxId:11886] [69782] (12 PDB entries)

4. Carboxyl-terminal src kinase (csk) [75498] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75499] (1 PDB entry)

5. Cbl [55587] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [55588] (3 PDB entries)

6. Crk proto-oncogen [82741] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [82742] (1 PDB entry)

7. Csk homologous kinase Chk [64345] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [64346] (1 PDB entry)

8. Ews/fli1 activated transcript 2, Eat2 [89999] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [90000] (1 PDB entry)

9. GRB2-related adaptor protein 2 (MONA, GRID) [111086] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [111087] (3 PDB entries)

10. Growth factor receptor-bound protein 10, GRB10 [89994] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89995] (1 PDB entry)

11. Growth factor receptor-bound protein 2 (GRB2) [55563] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55564] (13 PDB entries)

12. Growth factor receptor-bound protein 7 [103135] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [103136] (1 PDB entry)

13. Hemopoetic cell kinase Hck [55565] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55566] (4 PDB entries)

14. Itk/tsk protein tyrosine kinase [82743] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [82744] (4 PDB entries)

15. P55 Blk protein tyrosine kinase [55579] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [55580] (2 PDB entries)

16. p56-lck tyrosine kinase [55552] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55553] (10 PDB entries)

17. Phosphatidylinositol 3-kinase, p85-alpha subunit [55569] (3 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [55570] (7 PDB entries)

    2. Species Human (Homo sapiens) [TaxId:9606] [55571] (2 PDB entries)

    3. Species Rat (Rattus norvegicus) [TaxId:10116] [55572] (2 PDB entries)

18. Phospholipase C-gamma-1 [55577] (1 species)

    • Species Cow (Bos taurus) [TaxId:9913] [55578] (2 PDB entries)

19. Proto-oncogen tyrosine kinase [55573] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55574] (1 PDB entry)

20. Shc adaptor protein [55567] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55568] (2 PDB entries)

21. STAT homologue [103137] (1 species)

    • Species Slime mold (Dictyostelium discoideum) [TaxId:44689] [103138] (2 PDB entries)

22. STAT-1 [55583] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55584] (1 PDB entry)

23. STAT3b [55585] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [55586] (1 PDB entry)

24. Syk tyrosine kinase [55575] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55576] (3 PDB entries)

25. The Xlp protein Sap [55591] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55592] (6 PDB entries)

26. Tyrosine kinase Fyn [55559] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55560] (3 PDB entries)

27. Tyrosine phoshatase shp-2 [55589] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [55590] (1 PDB entry)

28. Tyrosine phosphatase Syp [55561] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [55562] (4 PDB entries)

29. Tyrosine-protein kinase 6 (Breast tumor kinase, Brk) [111084] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [111085] (1 PDB entry)

30. Tyrosine-protein kinase zap-70 [89996] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [89997] (1 PDB entry)

More info for Family d.93.1.1: SH2 domain

Timeline for Family d.93.1.1: SH2 domain:

• Family d.93.1.1: SH2 domain first appeared (with stable ids) in SCOP 1.55
  
• Family d.93.1.1: SH2 domain appears in SCOP 1.67
  
• Family d.93.1.1: SH2 domain appears in SCOP 1.71
  
• Family d.93.1.1: SH2 domain appears in the current release, SCOPe 2.08