SCOPe 2.02: Family d.92.1.5: Neurolysin-like

Lineage for Family d.92.1.5: Neurolysin-like

1. Root: SCOPe 2.02

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.5: Neurolysin-like [55505] (5 proteins)
   combines M2, M3 and M32 families of metalloproteases
   the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

Proteins:

1. Angiotensin converting enzyme 2, ACE2 [103125] (2 species)

   1. Species Human (Homo sapiens) [TaxId:9606] [103126] (4 PDB entries)

   2. Species Paguma larvata [188486] (2 PDB entries)

2. Angiotensin converting enzyme, ACE [82733] (2 species)
   M2 family member; overall fold is similar to that of neurolysin but is less elaborated

   1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [89991] (3 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [82734] (9 PDB entries)
      Uniprot P22966

3. Neurolysin (endopeptidase 24.16, thimet oligopeptidase) [55506] (2 species)
   M3 family member; the thermolysin-like catalytic domain consists of residues 352-674

   1. Species Human (Homo sapiens) [TaxId:9606] [111081] (2 PDB entries)
      Uniprot P52888

   2. Species Norway rat (Rattus norvegicus) [TaxId:10116] [55507] (1 PDB entry)

4. Thermostable carboxypeptidase 1 [82731] (1 species)
   M32 (Taq) family member; overall fold is similar to that of neurolysin but is less elaborated

   • Species Pyrococcus furiosus [TaxId:2261] [82732] (3 PDB entries)

5. automated matches [190340] (3 species)
   not a true protein

   1. Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [189355] (13 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [187164] (3 PDB entries)

   3. Species Norway rat (Rattus norvegicus) [TaxId:10116] [187944] (1 PDB entry)

More info for Family d.92.1.5: Neurolysin-like

Timeline for Family d.92.1.5: Neurolysin-like:

• Family d.92.1.5: Neurolysin-like first appeared (with stable ids) in SCOP 1.55, called Family d.92.1.5: Neurolysin (endopeptidase 24.16)
  
• Family d.92.1.5: Neurolysin-like appears in SCOPe 2.01
  
• Family d.92.1.5: Neurolysin-like appears in SCOPe 2.03
  
• Family d.92.1.5: Neurolysin-like appears in the current release, SCOPe 2.08