Lineage for Family d.92.1.5: Neurolysin-like

  1. Root: SCOP 1.73
  2. 713694Class d: Alpha and beta proteins (a+b) [53931] (334 folds)
  3. 729090Fold d.92: Zincin-like [55485] (2 superfamilies)
    contains mixed beta sheet with connection over free side of the sheet
  4. 729091Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (15 families) (S)
  5. 729182Family d.92.1.5: Neurolysin-like [55505] (4 proteins)
    combines M2, M3 and M32 families of metalloproteases
    the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain

Proteins:

  1. 729183Angiotensin converting enzyme 2, ACE2 [103125] (1 species)
  2. 729189Angiotensin converting enzyme, ACE [82733] (2 species)
    M2 family member; overall fold is similar to that of neurolysin but is less elaborated
    1. 729190Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [89991] (3 PDB entries)
    2. 729197Species Human (Homo sapiens) [TaxId:9606] [82734] (5 PDB entries)
  3. 729203Neurolysin (endopeptidase 24.16, thimet oligopeptidase) [55506] (2 species)
    M3 family member; the thermolysin-like catalytic domain consists of residues 352-674
    1. 729204Species Human (Homo sapiens) [TaxId:9606] [111081] (1 PDB entry)
    2. 729206Species Rat (Rattus norvegicus) [TaxId:10116] [55507] (1 PDB entry)
  4. 729208Thermostable carboxypeptidase 1 [82731] (1 species)
    M32 (Taq) family member; overall fold is similar to that of neurolysin but is less elaborated

More info for Family d.92.1.5: Neurolysin-like

Timeline for Family d.92.1.5: Neurolysin-like: