SCOPe 2.03: Family d.92.1.4: Neutral endopeptidase (neprilysin)

Lineage for Family d.92.1.4: Neutral endopeptidase (neprilysin)

1. Root: SCOPe 2.03

2. Class d: Alpha and beta proteins (a+b) [53931] (376 folds)

3. Fold d.92: Zincin-like [55485] (2 superfamilies)
   contains mixed beta sheet with connection over free side of the sheet

4. Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families)

5. Family d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (2 proteins)

Proteins:

1. Neutral endopeptidase (neprilysin) [55503] (1 species)
   contains thermolysin-like catalytic domain (residues 419-749)
   the N-terminal half of the structure is multihelical

   • Species Human (Homo sapiens) [TaxId:9606] [55504] (6 PDB entries)
     Uniprot P08473 54-749

2. automated matches [191254] (1 species)
   not a true protein

   • Species Human (Homo sapiens) [TaxId:9606] [189792] (1 PDB entry)

More info for Family d.92.1.4: Neutral endopeptidase (neprilysin)

Timeline for Family d.92.1.4: Neutral endopeptidase (neprilysin):

• Family d.92.1.4: Neutral endopeptidase (neprilysin) first appeared (with stable ids) in SCOP 1.55
  
• Family d.92.1.4: Neutral endopeptidase (neprilysin) appears in SCOPe 2.02
  
• Family d.92.1.4: Neutral endopeptidase (neprilysin) appears in SCOPe 2.04
  
• Family d.92.1.4: Neutral endopeptidase (neprilysin) appears in the current release, SCOPe 2.08