Class d: Alpha and beta proteins (a+b) [53931] (388 folds) |
Fold d.92: Zincin-like [55485] (2 superfamilies) contains mixed beta sheet with connection over free side of the sheet |
Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families) |
d.92.1.1: Zinc protease [55487] (2 proteins) single domain automatically mapped to Pfam PF02031 |
d.92.1.2: Thermolysin-like [55490] (5 proteins) includes alpha-helical C-terminal domain characteristic for the family |
d.92.1.3: Leishmanolysin [55499] (1 protein) automatically mapped to Pfam PF01457 |
d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (2 proteins) |
d.92.1.5: Neurolysin-like [55505] (5 proteins) combines M2, M3 and M32 families of metalloproteases the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain |
d.92.1.6: Serralysin-like metalloprotease, catalytic (N-terminal) domain [55508] (2 proteins) characteristic HEXXHXXGXXH motif and Met located near C-terminus |
d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins) |
d.92.1.8: Astacin [55516] (2 proteins) automatically mapped to Pfam PF01400 |
d.92.1.9: Reprolysin-like [55519] (3 proteins) Pfam PF01421 |
d.92.1.10: TNF-alpha converting enzyme, TACE, catalytic domain [55525] (2 proteins) automatically mapped to Pfam PF13574 automatically mapped to Pfam PF13583 |
d.92.1.11: Matrix metalloproteases, catalytic domain [55528] (14 proteins) |
d.92.1.12: Fungal zinc peptidase [64335] (1 protein) single domain with insertions in the common fold |
d.92.1.13: Zn aminopeptidase catalytic domain [64338] (5 proteins) adopts thermolysin-like fold |
d.92.1.14: Anthrax toxin lethal factor, N- and C-terminal domains [69775] (2 proteins) automatically mapped to Pfam PF07737 |
d.92.1.15: Predicted metal-dependent hydrolase [103132] (4 proteins) Pfam PF02130; UPF0054; COG0319; MMP-like fold with a different sequence motif in the putative active site |
d.92.1.16: Caur0242-like [160552] (1 protein) Pfam PF10103; DUF2342; there is a characteristic HExxH motif but no metal ion bound to it in the first structure. |
d.92.1.17: TTHA0227-like [160555] (2 proteins) Pfam PFPF06262; DUF1025; minimal zincin fold that retains 3-stranded mixed beta-sheet and contains HExxH motif in the C-terminal helix; no metal ion bound to this motif is observed in the first determined structures Pfam PF06262; DUF1025; minimal zincin fold that retains 3-stranded mixed beta-sheet and contains HExxH motif in the C-terminal helix; no metal ion bound to this motif is observed in the first determined structures |
d.92.1.0: automated matches [191495] (1 protein) not a true family |
Timeline for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain: