Lineage for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

  1. Root: SCOPe 2.03
  2. 1396887Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1423492Fold d.92: Zincin-like [55485] (2 superfamilies)
    contains mixed beta sheet with connection over free side of the sheet
  4. 1423493Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families) (S)

Families:

  1. 1423494d.92.1.1: Zinc protease [55487] (2 proteins)
    single domain
    automatically mapped to Pfam PF02031
  2. 1423507d.92.1.2: Thermolysin-like [55490] (5 proteins)
    includes alpha-helical C-terminal domain characteristic for the family
  3. 1423652d.92.1.3: Leishmanolysin [55499] (1 protein)
    automatically mapped to Pfam PF01457
  4. 1423656d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (2 proteins)
  5. 1423668d.92.1.5: Neurolysin-like [55505] (5 proteins)
    combines M2, M3 and M32 families of metalloproteases
    the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain
  6. 1423746d.92.1.6: Serralysin-like metalloprotease, catalytic (N-terminal) domain [55508] (2 proteins)
    characteristic HEXXHXXGXXH motif and Met located near C-terminus
  7. 1423777d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)
  8. 1423873d.92.1.8: Astacin [55516] (1 protein)
    automatically mapped to Pfam PF01400
  9. 1423884d.92.1.9: Reprolysin-like [55519] (3 proteins)
    Pfam PF01421
  10. 1423925d.92.1.10: TNF-alpha converting enzyme, TACE, catalytic domain [55525] (2 proteins)
    automatically mapped to Pfam PF13574
    automatically mapped to Pfam PF13583
  11. 1423977d.92.1.11: Matrix metalloproteases, catalytic domain [55528] (14 proteins)
  12. 1424345d.92.1.12: Fungal zinc peptidase [64335] (1 protein)
    single domain with insertions in the common fold
  13. 1424355d.92.1.13: Leukotriene A4 hydrolase catalytic domain [64338] (1 protein)
    adopts thermolysin-like fold
  14. 1424402d.92.1.14: Anthrax toxin lethal factor, N- and C-terminal domains [69775] (2 proteins)
    automatically mapped to Pfam PF07737
  15. 1424439d.92.1.15: Predicted metal-dependent hydrolase [103132] (3 proteins)
    Pfam PF02130; UPF0054; COG0319; MMP-like fold with a different sequence motif in the putative active site
  16. 1424452d.92.1.16: Caur0242-like [160552] (1 protein)
    Pfam PF10103; DUF2342; there is a characteristic HExxH motif but no metal ion bound to it in the first structure.
  17. 1424456d.92.1.17: TTHA0227-like [160555] (2 proteins)
    PF06262; DUF1025; minimal zincin fold that retains 3-stranded mixed beta-sheet and contains HExxH motif in the C-terminal helix; no metal ion bound to this motif is observed in the first determined structures
  18. 1424465d.92.1.0: automated matches [191495] (1 protein)
    not a true family

More info for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

Timeline for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain: