Lineage for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

  1. Root: SCOPe 2.02
  2. 1190016Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 1211973Fold d.92: Zincin-like [55485] (2 superfamilies)
    contains mixed beta sheet with connection over free side of the sheet
  4. 1211974Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain [55486] (18 families) (S)


  1. 1211975d.92.1.1: Zinc protease [55487] (2 proteins)
    single domain
  2. 1211984d.92.1.2: Thermolysin-like [55490] (5 proteins)
    includes alpha-helical C-terminal domain characteristic for the family
  3. 1212117d.92.1.3: Leishmanolysin [55499] (1 protein)
  4. 1212121d.92.1.4: Neutral endopeptidase (neprilysin) [55502] (2 proteins)
  5. 1212133d.92.1.5: Neurolysin-like [55505] (5 proteins)
    combines M2, M3 and M32 families of metalloproteases
    the N-terminal half of the structure is multihelical; the C-terminal half contains the thermolysin-like catalytic domain
  6. 1212199d.92.1.6: Serralysin-like metalloprotease, catalytic (N-terminal) domain [55508] (1 protein)
    characteristic HEXXHXXGXXH motif and Met located near C-terminus
  7. 1212225d.92.1.7: Clostridium neurotoxins, catalytic domain [55512] (2 proteins)
  8. 1212297d.92.1.8: Astacin [55516] (1 protein)
  9. 1212308d.92.1.9: Reprolysin-like [55519] (3 proteins)
    Pfam PF01421
  10. 1212349d.92.1.10: TNF-alpha converting enzyme, TACE, catalytic domain [55525] (2 proteins)
  11. 1212397d.92.1.11: Matrix metalloproteases, catalytic domain [55528] (14 proteins)
  12. 1212743d.92.1.12: Fungal zinc peptidase [64335] (1 protein)
    single domain with insertions in the common fold
  13. 1212753d.92.1.13: Leukotriene A4 hydrolase catalytic domain [64338] (1 protein)
    adopts thermolysin-like fold
  14. 1212771d.92.1.14: Anthrax toxin lethal factor, N- and C-terminal domains [69775] (1 protein)
  15. 1212805d.92.1.15: Predicted metal-dependent hydrolase [103132] (3 proteins)
    Pfam PF02130; UPF0054; COG0319; MMP-like fold with a different sequence motif in the putative active site
  16. 1212818d.92.1.16: Caur0242-like [160552] (1 protein)
    Pfam PF10103; DUF2342; there is a characteristic HExxH motif but no metal ion bound to it in the first structure.
  17. 1212822d.92.1.17: TTHA0227-like [160555] (2 proteins)
    PF06262; DUF1025; minimal zincin fold that retains 3-stranded mixed beta-sheet and contains HExxH motif in the C-terminal helix; no metal ion bound to this motif is observed in the first determined structures
  18. 1212831d.92.1.0: automated matches [191495] (1 protein)
    not a true family

More info for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain

Timeline for Superfamily d.92.1: Metalloproteases ("zincins"), catalytic domain: