SCOPe 2.08: Family d.65.1.2: Hedgehog (development protein), N-terminal signaling domain

Lineage for Family d.65.1.2: Hedgehog (development protein), N-terminal signaling domain

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.65: Hedgehog/DD-peptidase [55165] (1 superfamily)
   alpha-beta(2)-alpha-beta(2); 2 layers: alpha/beta

4. Superfamily d.65.1: Hedgehog/DD-peptidase [55166] (5 families)
   zinc-binding motif

5. Family d.65.1.2: Hedgehog (development protein), N-terminal signaling domain [55170] (3 proteins)
   automatically mapped to Pfam PF01085

Proteins:

1. Hedgehog [143496] (1 species)
   lacks the conserved metal ion-binding site

   • Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [143497] (1 PDB entry)
     Uniprot Q02936 50-198

2. Sonic hedgehog [55171] (1 species)

   • Species Mouse (Mus musculus) [TaxId:10090] [55172] (4 PDB entries)

3. automated matches [190324] (2 species)
   not a true protein

   1. Species Human (Homo sapiens) [TaxId:9606] [188953] (17 PDB entries)

   2. Species Mouse (Mus musculus) [TaxId:10090] [228020] (2 PDB entries)

More info for Family d.65.1.2: Hedgehog (development protein), N-terminal signaling domain

Timeline for Family d.65.1.2: Hedgehog (development protein), N-terminal signaling domain:

• Family d.65.1.2: Hedgehog (development protein), N-terminal signaling domain first appeared (with stable ids) in SCOP 1.55, called Family d.65.1.2: Hedgehog (development protein), N-terminal signalling domain
  
• Family d.65.1.2: Hedgehog (development protein), N-terminal signaling domain appears in SCOPe 2.07