Lineage for Superfamily d.58.18: ACT-like

  1. Root: SCOP 1.73
  2. 713694Class d: Alpha and beta proteins (a+b) [53931] (334 folds)
  3. 723373Fold d.58: Ferredoxin-like [54861] (55 superfamilies)
    alpha+beta sandwich with antiparallel beta-sheet; (beta-alpha-beta)x2
  4. 725281Superfamily d.58.18: ACT-like [55021] (12 families) (S)
    regulatory domain linked to a wide range of metabolic enzymes

Families:

  1. 725282d.58.18.1: Phosphoglycerate dehydrogenase, regulatory (C-terminal) domain [55022] (1 protein)
  2. 725307d.58.18.2: Allosteric threonine deaminase C-terminal domain [55025] (1 protein)
  3. 725312d.58.18.3: Phenylalanine hydroxylase N-terminal domain [55028] (1 protein)
  4. 725317d.58.18.4: Nickel responsive regulator NikR, C-terminal domain [102999] (1 protein)
  5. 725351d.58.18.5: Glycine cleavage system transcriptional repressor [110980] (1 protein)
    tandem repeat of two ACT-like domains; swapped domain dimer
  6. 725358d.58.18.6: IlvH-like [143376] (1 protein)
    Duplication: tandem repeat of two ACT-like domains; dimer, the N- and C-terminal domains have different dimerisation modes
  7. 725377d.58.18.7: SP0238-like [143381] (1 protein)
    stand-alone protein; dimer, the dimerization interface is formed by parallel packing of the subunit beta-sheets
  8. 725383d.58.18.8: Atu0741-like [143384] (1 protein)
    duplication: tandem repeat of two ACT-like domains; contains strand invasion of extra N-terminal strand into the C-terminal domain beta-sheet; dimerizes with the formation of orthogonally packed intersubunit beta-sheets
  9. 725388d.58.18.9: VC0802-like [143387] (1 protein)
    duplication: tandem repeat of two ACT-like domains; contains circular permutation (the C-terminal strand replacement with extra N-terminal strand); dimerizes with the formation of orthogonally packed intersubunit beta-sheets
  10. 725399d.58.18.10: Aspartokinase allosteric domain-like [143390] (1 protein)
    duplication: tandem repeat of two ACT-like domains; similar subunit and oligomeric structures to the VC0802-like family
  11. 725422d.58.18.11: BT0572-like [143395] (1 protein)
    duplication: tandem repeat of two ACT-like domains; dimerizes with the formation of orthogonally packed intersubunit beta-sheets
  12. 725429d.58.18.12: AF1403 N-terminal domain-like [143398] (1 protein)
    dimerizes with the formation of a single intersubunit beta-sheet

More info for Superfamily d.58.18: ACT-like

Timeline for Superfamily d.58.18: ACT-like: