SCOPe 2.08: Family d.32.1.2: Antibiotic resistance proteins

Lineage for Family d.32.1.2: Antibiotic resistance proteins

1. Root: SCOPe 2.08

2. Class d: Alpha and beta proteins (a+b) [53931] (396 folds)

3. Fold d.32: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54592] (1 superfamily)
   beta-alpha-beta(3); 2 layers: alpha/beta

4. Superfamily d.32.1: Glyoxalase/Bleomycin resistance protein/Dihydroxybiphenyl dioxygenase [54593] (11 families)

5. Family d.32.1.2: Antibiotic resistance proteins [54598] (8 proteins)
   duplication: consists of two clear structural repeats each having this fold
   subunit fold and dimeric assembly are similar to those of glyoxalase

Proteins:

1. Bleomycin resistance protein, BRP [54599] (3 species)
   Active as dimer

   1. Species Klebsiella pneumoniae [TaxId:573] [64256] (4 PDB entries)
      the transposon tn5-encoding bleomycin-binding protein, BlmT

   2. Species Streptoalloteichus hindustanus [TaxId:2017] [54601] (2 PDB entries)
      Uniprot P17493

   3. Species Streptomyces verticillus [TaxId:29309] [54600] (3 PDB entries)

2. Fosfomycin resistance protein A (FosA) [82630] (2 species)

   1. Species Pseudomonas aeruginosa [TaxId:287] [82631] (5 PDB entries)

   2. Species Serratia marcescens [TaxId:615] [102871] (1 PDB entry)
      gene from transposon tn2921

3. Fosfomycin resistance protein FosX [102872] (1 species)

   • Species Mesorhizobium loti [TaxId:381] [102873] (1 PDB entry)

4. Hypotheical protein SP0731 [143127] (1 species)

   • Species Pneumococcus (Streptococcus pneumoniae) [TaxId:1313] [143128] (1 PDB entry)
     Uniprot Q97RR3 1-115

5. Hypothetical protein BC3580 [117870] (1 species)

   • Species Bacillus cereus [TaxId:1396] [117871] (1 PDB entry)
     Uniprot Q81AI8

6. Mitomycin resistance protein D, MRD [75394] (1 species)

   • Species Streptomyces lavendulae [TaxId:1914] [75395] (2 PDB entries)

7. Uncharacterized protein Atu1953 [160145] (1 species)

   • Species Agrobacterium tumefaciens [TaxId:358] [160146] (1 PDB entry)
     Uniprot Q8UE11 2-115

8. automated matches [190190] (5 species)
   not a true protein

   1. Species Listeria monocytogenes [TaxId:169963] [187361] (5 PDB entries)

   2. Species Pneumococcus (Streptococcus pneumoniae) [TaxId:1313] [187844] (1 PDB entry)

   3. Species Streptoalloteichus hindustanus [TaxId:2017] [188784] (1 PDB entry)

   4. Species Streptomyces caespitosus [TaxId:53502] [186930] (2 PDB entries)

   5. Species Streptomyces flavoviridis [TaxId:66889] [193979] (2 PDB entries)

More info for Family d.32.1.2: Antibiotic resistance proteins

Timeline for Family d.32.1.2: Antibiotic resistance proteins:

• Family d.32.1.2: Antibiotic resistance proteins first appeared (with stable ids) in SCOP 1.55, called Family d.32.1.2: Bleomycin resistance protein, BRP
  
• Family d.32.1.2: Antibiotic resistance proteins appears in SCOPe 2.07