SCOPe 2.05: Family d.26.1.1: FKBP immunophilin/proline isomerase

Lineage for Family d.26.1.1: FKBP immunophilin/proline isomerase

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.26: FKBP-like [54533] (3 superfamilies)
   core: beta(2)-alpha-beta(2); antiparallel beta-sheet

4. Superfamily d.26.1: FKBP-like [54534] (4 families)

5. Family d.26.1.1: FKBP immunophilin/proline isomerase [54535] (17 proteins)

Proteins:

1. Archaeal FKBP [89879] (1 species)
   contains insert all-beta subdomain; dual function: PPI and chaperone-like activities

   • Species Methanococcus thermolithotrophicus [TaxId:2186] [89880] (1 PDB entry)

2. Calcineurin (FKBP12.6) [54539] (3 species)

   1. Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [54542] (1 PDB entry)

   2. Species Cow (Bos taurus) [TaxId:9913] [54541] (1 PDB entry)

   3. Species Human (Homo sapiens) [TaxId:9606] [54540] (1 PDB entry)

3. FK-506 binding protein (FKBP12), an immunophilin [54536] (2 species)
   cis-trans prolyl-isomerase

   1. Species Cow (Bos taurus) [TaxId:9913] [54538] (2 PDB entries)

   2. Species Human (Homo sapiens) [TaxId:9606] [54537] (42 PDB entries)

4. FKB-6, N-terminal domain [102864] (1 species)

   • Species Nematode (Caenorhabditis elegans) [TaxId:6239] [102865] (1 PDB entry)

5. FKBP13 [110870] (1 species)

   • Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [110871] (2 PDB entries)
     Uniprot Q9SCY2 84-208

6. FKBP25 [54543] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54544] (1 PDB entry)

7. FKBP51, N-terminal domains [82621] (2 species)
   duplication: tandem repeat of two FKBP domains

   1. Species Human (Homo sapiens) [TaxId:9606] [82622] (1 PDB entry)

   2. Species Monkey (Saimiri boliviensis) [TaxId:27679] [82623] (1 PDB entry)

8. FKBP52, N-terminal domains [82619] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [82620] (10 PDB entries)
     Uniprot Q02790 21-427; contains tandem repeat of two FKPB domains

9. FKBP59-I, N-terminal domain [54545] (1 species)

   • Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [54546] (2 PDB entries)

10. Macrophage infectivity potentiator protein (MIP) [64250] (2 species)
    contains all-alpha dimerisation subdomain in the N-terminal extension

    1. Species Legionella pneumophila [TaxId:446] [64251] (1 PDB entry)

    2. Species Trypanosoma cruzi [TaxId:5693] [75387] (1 PDB entry)

11. Mitotic rotamase PIN1, domain 2 [54547] (2 species)
    Domain 1 is a WW-domain

    1. Species Human (Homo sapiens) [TaxId:9606] [54548] (46 PDB entries)

    2. Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [75386] (1 PDB entry)

12. Parvulin [64248] (1 species)

    • Species Human (Homo sapiens), hpar14 [TaxId:9606] [64249] (2 PDB entries)

13. Parvulin 10 (rotamase C) [89877] (1 species)

    • Species Escherichia coli [TaxId:562] [89878] (2 PDB entries)

14. Peptidyl-prolyl cis-trans isomerase FkpA [102866] (1 species)
    similar to MIP; contains all-alpha dimerisation subdomain in the N-terminal extension

    • Species Escherichia coli [TaxId:562] [102867] (3 PDB entries)

15. Porin chaperone SurA, PPIase domains [82624] (1 species)

    • Species Escherichia coli [TaxId:562] [82625] (4 PDB entries)

16. Trigger factor PPIase domain [75388] (3 species)

    1. Species Escherichia coli [TaxId:562] [89881] (3 PDB entries)
       Uniprot P22257

    2. Species Mycoplasma genitalium [TaxId:2097] [75389] (1 PDB entry)

    3. Species Vibrio cholerae [TaxId:666] [110869] (1 PDB entry)
       Uniprot Q9KQS5

17. automated matches [191209] (3 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [189839] (38 PDB entries)

    2. Species Mouse (Mus musculus) [TaxId:10090] [189566] (1 PDB entry)

    3. Species Yellow fever mosquito (Aedes aegypti) [TaxId:7159] [195032] (2 PDB entries)

More info for Family d.26.1.1: FKBP immunophilin/proline isomerase

Timeline for Family d.26.1.1: FKBP immunophilin/proline isomerase:

• Family d.26.1.1: FKBP immunophilin/proline isomerase first appeared (with stable ids) in SCOP 1.55
  
• Family d.26.1.1: FKBP immunophilin/proline isomerase appears in SCOPe 2.04
  
• Family d.26.1.1: FKBP immunophilin/proline isomerase appears in SCOPe 2.06
  
• Family d.26.1.1: FKBP immunophilin/proline isomerase appears in the current release, SCOPe 2.08