Lineage for Family d.26.1.1: FKBP immunophilin/proline isomerase

  1. Root: SCOPe 2.07
  2. 2494617Class d: Alpha and beta proteins (a+b) [53931] (388 folds)
  3. 2509610Fold d.26: FKBP-like [54533] (3 superfamilies)
    core: beta(2)-alpha-beta(2); antiparallel beta-sheet
  4. 2509611Superfamily d.26.1: FKBP-like [54534] (4 families) (S)
  5. 2509612Family d.26.1.1: FKBP immunophilin/proline isomerase [54535] (17 protein domains)

Protein Domains:

  1. 2509613Archaeal FKBP [89879] (1 species)
    contains insert all-beta subdomain; dual function: PPI and chaperone-like activities
  2. 2509616Calcineurin (FKBP12.6) [54539] (3 species)
    1. 2509617Species Baker's yeast (Saccharomyces cerevisiae) [TaxId:4932] [54542] (1 PDB entry)
    2. 2509619Species Cow (Bos taurus) [TaxId:9913] [54541] (1 PDB entry)
    3. 2509621Species Human (Homo sapiens) [TaxId:9606] [54540] (4 PDB entries)
  3. 2509628FK-506 binding protein (FKBP12), an immunophilin [54536] (2 species)
    cis-trans prolyl-isomerase
    1. 2509629Species Cow (Bos taurus) [TaxId:9913] [54538] (2 PDB entries)
    2. 2509632Species Human (Homo sapiens) [TaxId:9606] [54537] (42 PDB entries)
  4. 2509691FKB-6, N-terminal domain [102864] (1 species)
  5. 2509694FKBP13 [110870] (1 species)
  6. 2509706FKBP25 [54543] (1 species)
  7. 2509711FKBP51, N-terminal domains [82621] (2 species)
    duplication: tandem repeat of two FKBP domains
    1. 2509712Species Human (Homo sapiens) [TaxId:9606] [82622] (1 PDB entry)
    2. 2509715Species Monkey (Saimiri boliviensis) [TaxId:27679] [82623] (1 PDB entry)
  8. 2509718FKBP52, N-terminal domains [82619] (1 species)
  9. 2509747FKBP59-I, N-terminal domain [54545] (1 species)
  10. 2509751Macrophage infectivity potentiator protein (MIP) [64250] (2 species)
    contains all-alpha dimerisation subdomain in the N-terminal extension
    1. 2509752Species Legionella pneumophila [TaxId:446] [64251] (1 PDB entry)
    2. 2509754Species Trypanosoma cruzi [TaxId:5693] [75387] (1 PDB entry)
  11. 2509756Mitotic rotamase PIN1, domain 2 [54547] (2 species)
    Domain 1 is a WW-domain
    1. 2509757Species Human (Homo sapiens) [TaxId:9606] [54548] (47 PDB entries)
    2. 2509807Species Thale cress (Arabidopsis thaliana) [TaxId:3702] [75386] (1 PDB entry)
  12. 2509809Parvulin [64248] (1 species)
  13. 2509813Parvulin 10 (rotamase C) [89877] (1 species)
  14. 2509817Peptidyl-prolyl cis-trans isomerase FkpA [102866] (1 species)
    similar to MIP; contains all-alpha dimerisation subdomain in the N-terminal extension
  15. 2509824Porin chaperone SurA, PPIase domains [82624] (1 species)
  16. 2509841Trigger factor PPIase domain [75388] (3 species)
    1. 2509842Species Escherichia coli [TaxId:562] [89881] (3 PDB entries)
      Uniprot P22257
    2. 2509847Species Mycoplasma genitalium [TaxId:2097] [75389] (1 PDB entry)
    3. 2509849Species Vibrio cholerae [TaxId:666] [110869] (1 PDB entry)
      Uniprot Q9KQS5
  17. 2509852automated matches [191209] (4 species)
    not a true protein
    1. 2509853Species Candida glabrata [TaxId:284593] [322580] (2 PDB entries)
    2. 2509856Species Human (Homo sapiens) [TaxId:9606] [189839] (42 PDB entries)
    3. 2509908Species Mouse (Mus musculus) [TaxId:10090] [189566] (1 PDB entry)
    4. 2509910Species Yellow fever mosquito (Aedes aegypti) [TaxId:7159] [195032] (2 PDB entries)

More info for Family d.26.1.1: FKBP immunophilin/proline isomerase

Timeline for Family d.26.1.1: FKBP immunophilin/proline isomerase: