Lineage for Protein: Heterochromatin protein 1, HP1

  1. Root: SCOPe 2.05
  2. 1755445Class b: All beta proteins [48724] (176 folds)
  3. 1783288Fold b.34: SH3-like barrel [50036] (21 superfamilies)
    barrel, partly opened; n*=4, S*=8; meander
    the last strand is interrupted by a turn of 3-10 helix
  4. 1785119Superfamily b.34.13: Chromo domain-like [54160] (4 families) (S)
    SH3-like barrel is capped by a C-terminal helix
  5. 1785158Family b.34.13.2: Chromo domain [54165] (8 proteins)
    lacks the SH3-like barrel first strand that can be complemented by bound peptide ligand; in shadow chromo domain the corresponding site is altered by insertion; similarity to the IL8-like fold
  6. 1785203Protein Heterochromatin protein 1, HP1 [54166] (4 species)
    duplication: consists of two homologous domains, N-terminal chromo domain and C-terminal chromo shadow domain

Species:

  1. 1785204Fission yeast (Schizosaccharomyces pombe), SWI6 [TaxId:4896] [54169] (1 PDB entry)
    • Domains for 1e0b:
      1. 1785205Domain d1e0ba_: 1e0b A: [37476]
        C-terminal shadow chromo domain
        complexed with 1pg
      2. 1785206Domain d1e0bb_: 1e0b B: [37477]
        C-terminal shadow chromo domain
        complexed with 1pg
  2. 1785207Fruit fly (Drosophila melanogaster) [TaxId:7227] [75343] (3 PDB entries)
    Uniprot P05205 23-74
    1. Domain for 1kna:
      • 1785209Domain d1knaa_: 1kna A: [72771]
        Chromo domain complexed with histone h3 tail containing dimethyllysine 9
    2. Domain for 1kne:
      • 1785210Domain d1knea_: 1kne A: [72774]
        Chromo domain complexed with histone h3 tail containing trimethyllysine 9
    3. Domain for 1q3l:
      • 1785208Domain d1q3la_: 1q3l A: [111652]
        complexed with histone H3 tail containing monomethyllysine 9 (Uniprot P16106 5-10), chain P
  3. 1785211Human (Homo sapiens) [TaxId:9606] [187099] (3 PDB entries)
    1. Domains for 2fmm:
      1. 1785212Domain d2fmma_: 2fmm A: [133782]
        Other proteins in same PDB: d2fmme1
        automated match to d1s4za_
        complexed with so4
      2. 1785213Domain d2fmmb_: 2fmm B: [133783]
        Other proteins in same PDB: d2fmme1
        automated match to d1s4za_
        complexed with so4
      3. 1785214Domain d2fmmc_: 2fmm C: [133784]
        Other proteins in same PDB: d2fmme1
        automated match to d1s4za_
        complexed with so4
      4. 1785215Domain d2fmmd_: 2fmm D: [133785]
        Other proteins in same PDB: d2fmme1
        automated match to d1s4za_
        complexed with so4
    2. Domain for 3f2u:
    3. Domains for 3q6s:
      1. 1785217Domain d3q6sa_: 3q6s A: [184231]
        automated match to d1s4za_
      2. 1785218Domain d3q6sb_: 3q6s B: [184232]
        automated match to d1s4za_
      3. 1785219Domain d3q6sc_: 3q6s C: [184233]
        automated match to d1s4za_
      4. 1785220Domain d3q6sd_: 3q6s D: [184234]
        automated match to d1s4za_
  4. 1785221Mouse (Mus musculus), HP1 beta (MOD1, M31) [TaxId:10090] [54167] (4 PDB entries)
    1. Domain for 1ap0:
    2. Domains for 1dz1:
      1. 1785222Domain d1dz1a_: 1dz1 A: [37473]
        C-terminal shadow chromo domain
      2. 1785223Domain d1dz1b_: 1dz1 B: [37474]
        C-terminal shadow chromo domain
    3. Domain for 1guw:
      • 1785224Domain d1guwa_: 1guw A: [70584]
        Chromo domain complexed with the lysine 9-methyl histone H3 N-terminal peptide
    4. Domains for 1s4z:
      1. 1785225Domain d1s4za_: 1s4z A: [98515]
        Chromo shadow domain complexed with pxvxl motif peptide of caf-1, chain C
      2. 1785226Domain d1s4zb_: 1s4z B: [98516]
        Chromo shadow domain complexed with pxvxl motif peptide of caf-1, chain C

More info for Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain

Timeline for Protein Heterochromatin protein 1, HP1 from b.34.13.2: Chromo domain: