Lineage for Family b.34.13.2: Chromo domain

  1. Root: SCOP 1.67
  2. 362614Class b: All beta proteins [48724] (141 folds)
  3. 372425Fold b.34: SH3-like barrel [50036] (15 superfamilies)
    barrel, partly opened; n*=4, S*=8; meander
    the last strand is interrupted by a turn of 3-10 helix
  4. 373032Superfamily b.34.13: Chromo domain-like [54160] (2 families) (S)
    SH3-like barrel is capped by a C-terminal helix
  5. 373050Family b.34.13.2: Chromo domain [54165] (3 proteins)
    lacks the SH3-like barrel first strand that can be complemented by bound peptide ligand; in shadow chromo domain the corresponding site is altered by insertion; similarity to the IL8-like fold

Proteins:

  1. 373051Heterochromatin protein 1, HP1 [54166] (3 species)
    duplication: consists of two homologous domains, N-terminal chromo domain and C-terminal chromo shadow domain
    1. 373052Species Fission yeast (Schizosaccharomyces pombe), SWI6 [TaxId:4896] [54169] (1 PDB entry)
    2. 373055Species Fruit fly (Drosophila melanogaster) [TaxId:7227] [75343] (2 PDB entries)
    3. 373058Species Mouse (Mus musculus), HP1 beta (MOD1, M31) [TaxId:10090] [54167] (4 PDB entries)
  2. 373065Histone methyltransferase clr4, chromo domain [64217] (1 species)
  3. 373068Polycomb protein, Pc [101688] (1 species)

More info for Family b.34.13.2: Chromo domain

Timeline for Family b.34.13.2: Chromo domain: