SCOPe 2.05: Family d.9.1.1: Interleukin 8-like chemokines

Lineage for Family d.9.1.1: Interleukin 8-like chemokines

1. Root: SCOPe 2.05

2. Class d: Alpha and beta proteins (a+b) [53931] (381 folds)

3. Fold d.9: IL8-like [54116] (2 superfamilies)
   beta(3)-alpha

4. Superfamily d.9.1: Interleukin 8-like chemokines [54117] (2 families)
   form dimers with different dimerisation modes

5. Family d.9.1.1: Interleukin 8-like chemokines [54118] (25 proteins)

Proteins:

1. CC chemokine I-309 [54138] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54139] (1 PDB entry)

2. Chemokine domain of fractalkine [54146] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54147] (2 PDB entries)

3. Chemokine hcc-2 (macrophage inflammatory protein-5) [54154] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54155] (1 PDB entry)

4. Eotaxin [54140] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54141] (2 PDB entries)

5. Eotaxin-2 [54142] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54143] (2 PDB entries)

6. Eotaxin-3 [75341] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [75342] (2 PDB entries)

7. Gro beta [54156] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54157] (1 PDB entry)

8. IL-8/MGSA chimeric protein CIL-8M [54126] (1 species)
   IL-8: residues 1-53; MGSA: residues 54-72

   • Species Human (Homo sapiens) [TaxId:9606] [54127] (1 PDB entry)

9. Interleukin-8, IL-8 [54119] (1 species)

   • Species Human (Homo sapiens) [TaxId:9606] [54120] (11 PDB entries)

10. IP-10/CXCL10 [82573] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [82574] (4 PDB entries)

11. Lymphotactin [69632] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [69633] (2 PDB entries)

12. Macrophage inflammatory protein, MIP [54128] (5 species)
    has different dimerisation mode

    1. Species Human (Homo sapiens), 1-alpha [TaxId:9606] [54130] (3 PDB entries)

    2. Species Human (Homo sapiens), 1-beta [TaxId:9606] [54129] (3 PDB entries)

    3. Species Human (Homo sapiens), ccl20/mip-3a [TaxId:9606] [75340] (3 PDB entries)

    4. Species Kaposi's sarcoma-associated herpesvirus, VMIP-II [TaxId:37296] [54131] (7 PDB entries)
       anti-HIV chemokine

    5. Species Mouse (Mus musculus), ccl20/mip-3a [TaxId:10090] [64214] (1 PDB entry)

13. Macrophage inflammatory protein-2 [54152] (1 species)

    • Species Mouse (Mus musculus) [TaxId:10090] [54153] (2 PDB entries)

14. Melanoma growth stimulating activity (MGSA) [54124] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [54125] (3 PDB entries)

15. Monocyte chemoattractant protein-1 (MCP-1, MCAF) [54134] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [54135] (6 PDB entries)

16. Monocyte chemoattractant protein-2 (MCP-2) [54136] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [54137] (1 PDB entry)

17. Monocyte chemoattractant protein-3 (MCP-3) [54144] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [54145] (2 PDB entries)

18. Myeloid progenitor inhibitory factor-1 (MPIF-1) [64215] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [64216] (1 PDB entry)

19. Platelet basic protein, PBP [54148] (1 species)
    synonym: Small inducible cytokine B7; Neutrophil-activating peptide-2 (NAP-2), Connective tissue activating peptide-III (CTAP-III)

    • Species Human (Homo sapiens) [TaxId:9606] [54149] (3 PDB entries)

20. Platelet factor 4, PF4 [54121] (2 species)

    1. Species Cow (Bos taurus) [TaxId:9913] [54122] (1 PDB entry)

    2. Species Human (Homo sapiens) [TaxId:9606] [54123] (6 PDB entries)

21. RANTES (regulated upon activation, normal T-cell expressed and secreted) [54132] (1 species)
    has different dimerisation mode

    • Species Human (Homo sapiens) [TaxId:9606] [54133] (10 PDB entries)
      Uniprot P13501 25-91

22. Small inducible cytokine b11 (CXCL11/I-TAC) [102732] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [102733] (1 PDB entry)

23. Stromal cell-derived factor-1 (SDF-1) [54150] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [54151] (19 PDB entries)

24. Thymus and activation-regulated chemokine, TRAC [102730] (1 species)

    • Species Human (Homo sapiens) [TaxId:9606] [102731] (2 PDB entries)

25. automated matches [190403] (3 species)
    not a true protein

    1. Species Human (Homo sapiens) [TaxId:9606] [187277] (18 PDB entries)

    2. Species Human herpesvirus 8 strain gk18 [TaxId:868565] [269363] (1 PDB entry)

    3. Species Mouse (Mus musculus) [TaxId:10090] [188560] (1 PDB entry)

More info for Family d.9.1.1: Interleukin 8-like chemokines

Timeline for Family d.9.1.1: Interleukin 8-like chemokines:

• Family d.9.1.1: Interleukin 8-like chemokines first appeared (with stable ids) in SCOP 1.55
  
• Family d.9.1.1: Interleukin 8-like chemokines appears in SCOPe 2.04
  
• Family d.9.1.1: Interleukin 8-like chemokines appears in SCOPe 2.06
  
• Family d.9.1.1: Interleukin 8-like chemokines appears in the current release, SCOPe 2.08