Lineage for Family d.3.1.1: Papain-like

  1. Root: SCOP 1.75
  2. 849709Class d: Alpha and beta proteins (a+b) [53931] (376 folds)
  3. 851268Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 851269Superfamily d.3.1: Cysteine proteinases [54001] (22 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 851270Family d.3.1.1: Papain-like [54002] (25 proteins)

Proteins:

  1. 851271(Pro)cathepsin B [54022] (3 species)
    1. 851272Species Cow (Bos taurus) [TaxId:9913] [54025] (11 PDB entries)
    2. 851284Species Human (Homo sapiens) [TaxId:9606] [54023] (6 PDB entries)
    3. 851295Species Rat (Rattus norvegicus) [TaxId:10116] [54024] (4 PDB entries)
  2. 851304(Pro)cathepsin K [54028] (2 species)
    1. 851305Species Human (Homo sapiens) [TaxId:9606] [54029] (31 PDB entries)
      Uniprot P43235 116-329
      Uniprot P43235 115-329
      Uniprot P43235 116-329 ! Uniprot P43235 115-329
    2. 851344Species Rabbit (Oryctolagus cuniculus) [TaxId:9986] [142845] (1 PDB entry)
      Uniprot P43236 115-329
  3. 851346(Pro)cathepsin L [54026] (1 species)
  4. 851354(Pro)cathepsin S [82566] (1 species)
  5. 851393(Pro)cathepsin V [64202] (1 species)
  6. 851397(Pro)cathepsin X [54031] (1 species)
  7. 851403Actinidin [54003] (1 species)
  8. 851407Bleomycin hydrolase [54017] (2 species)
    DNA-binding protease that has more insertions in the papain-like fold
    1. 851408Species Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId:4932] [54018] (3 PDB entries)
    2. 851412Species Human (Homo sapiens) [TaxId:9606] [54019] (2 PDB entries)
  9. 851418Caricain (protease omega) [54007] (1 species)
  10. 851425Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330] (2 species)
    1. 851426Species Human (Homo sapiens) [TaxId:9606] [75331] (1 PDB entry)
    2. 851428Species Rat (Rattus norvegicus) [TaxId:10116] [82565] (1 PDB entry)
  11. 851430Cathepsin F [89805] (1 species)
  12. 851434Cathepsin H [81637] (1 species)
    also contains a disulfide-bound minicathepsin H chain
  13. 851445Chymopapain [54009] (1 species)
  14. 851448Cruzain [54020] (1 species)
  15. 851469Ervatamin B [89803] (1 species)
  16. 851472Ervatamin C [102717] (1 species)
  17. 851476Falcipain 2 [142846] (1 species)
  18. 851484Glycyl endopeptidase [54011] (1 species)
  19. 851487Major mite fecal allergen der p 1 [142848] (1 species)
  20. 851492Papain [54005] (1 species)
  21. 851512Proline-specific cysteine protease [54013] (1 species)
  22. 851518Staphopain SspB [102721] (1 species)
  23. 851528Staphopain StpA [54033] (1 species)
  24. 851531Streptococcal pyrogenic exotoxin B [54035] (1 species)
  25. 851541Vignain (bean endopeptidase) [102719] (1 species)

More info for Family d.3.1.1: Papain-like

Timeline for Family d.3.1.1: Papain-like: