Lineage for Family d.3.1.1: Papain-like

  1. Root: SCOP 1.65
  2. 323018Class d: Alpha and beta proteins (a+b) [53931] (234 folds)
  3. 324261Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 324262Superfamily d.3.1: Cysteine proteinases [54001] (9 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet
  5. 324263Family d.3.1.1: Papain-like [54002] (20 proteins)

Proteins:

  1. 324264(Pro)cathepsin B [54022] (3 species)
    1. 324265Species Cow (Bos taurus) [TaxId:9913] [54025] (2 PDB entries)
    2. 324268Species Human (Homo sapiens) [TaxId:9606] [54023] (6 PDB entries)
    3. 324279Species Rat (Rattus norvegicus) [TaxId:10116] [54024] (4 PDB entries)
  2. 324288(Pro)cathepsin K [54028] (1 species)
  3. 324309(Pro)cathepsin L [54026] (1 species)
  4. 324317(Pro)cathepsin S [82566] (1 species)
  5. 324324(Pro)cathepsin V [64202] (1 species)
  6. 324328(Pro)cathepsin X [54031] (1 species)
  7. 324334Actinidin [54003] (1 species)
  8. 324338Bleomycin hydrolase [54017] (2 species)
    DNA-binding protease that has more insertions in the papain-like fold
    1. 324339Species Baker's yeast (Saccharomyces cerevisiae), Gal6 [TaxId:4932] [54018] (3 PDB entries)
    2. 324343Species Human (Homo sapiens) [TaxId:9606] [54019] (2 PDB entries)
  9. 324349Caricain (protease omega) [54007] (1 species)
  10. 324356Cathepsin C (dipeptidyl peptidase I), catalytic domain [75330] (2 species)
    1. 324357Species Human (Homo sapiens) [TaxId:9606] [75331] (1 PDB entry)
    2. 324359Species Rat (Rattus norvegicus) [TaxId:10116] [82565] (1 PDB entry)
  11. 324361Cathepsin F [89805] (1 species)
  12. 324365Cathepsin H [81637] (1 species)
    also contains a disulfide-bound minicathepsin H chain
  13. 324376Chymopapain [54009] (1 species)
  14. 324379Cruzain [54020] (1 species)
  15. 324395Ervatamin B [89803] (1 species)
  16. 324398Glycyl endopeptidase [54011] (1 species)
  17. 324401Papain [54005] (1 species)
  18. 324419Proline-specific cysteine protease [54013] (1 species)
  19. 324425Staphopain [54033] (1 species)
  20. 324428Streptococcal pyrogenic exotoxin B [54035] (1 species)

More info for Family d.3.1.1: Papain-like

Timeline for Family d.3.1.1: Papain-like: