Lineage for Superfamily d.3.1: Cysteine proteinases

  1. Root: SCOP 1.71
  2. 595667Class d: Alpha and beta proteins (a+b) [53931] (286 folds)
  3. 597009Fold d.3: Cysteine proteinases [54000] (1 superfamily)
    consists of one alpha-helix and 4 strands of antiparallel beta-sheet and contains the catalytic triad Cys-His-Asn
  4. 597010Superfamily d.3.1: Cysteine proteinases [54001] (12 families) (S)
    the constitute families differ by insertion into and circular permutation of the common catalytic core made of one alpha-helix and 3-strands of beta-sheet

Families:

  1. 597011d.3.1.1: Papain-like [54002] (23 protein domains)
  2. 597209d.3.1.2: FMDV leader protease [54037] (1 protein)
  3. 597223d.3.1.3: Calpain large subunit, catalytic domain (domain II) [54040] (1 protein)
  4. 597239d.3.1.4: Transglutaminase catalytic domain [54044] (1 protein)
  5. 597283d.3.1.5: Arylamine N-acetyltransferase [54047] (1 protein)
    fold similar to that of the factor XIII catalytic domain
  6. 597299d.3.1.6: Ubiquitin carboxyl-terminal hydrolase UCH-l3 [54050] (1 protein)
  7. 597308d.3.1.7: Adenain-like [54054] (4 protein domains)
    Pfam 02902; Ulp1 protease family
  8. 597324d.3.1.8: Microbial transglutaminase [75336] (1 protein)
    inverted positions of the catalytic triad Asp and His residues
  9. 597331d.3.1.9: Ubiquitin carboxyl-terminal hydrolase, UCH [82568] (2 protein domains)
    Pfam 00443
  10. 597342d.3.1.10: Avirulence protein Avrpph3 [102723] (1 protein)
  11. 597346d.3.1.11: Ubiquitin thiolesterase protein OTUB2 (Otubain-2) [110773] (1 protein)
    probably the same as Pfam 02338, OTU-like cysteine protease, but 1TFF (SQ Q96DC9) was not detected by the Pfam model
  12. 597350d.3.1.12: IgG-specific endopeptidase IdeS (Sib38) [117762] (1 protein)

More info for Superfamily d.3.1: Cysteine proteinases

Timeline for Superfamily d.3.1: Cysteine proteinases: