SCOPe 2.08: Protein: Lactoferrin

Lineage for Protein: Lactoferrin

Root: SCOPe 2.08
Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

Fold c.94: Periplasmic binding protein-like II [53849] (1 superfamily)
consists of two similar intertwined domain with 3 layers (a/b/a) each: duplication
mixed beta-sheet of 5 strands, order 21354; strand 5 is antiparallel to the rest

Superfamily c.94.1: Periplasmic binding protein-like II [53850] (4 families)
Similar in architecture to the superfamily I but partly differs in topology
Family c.94.1.2: Transferrin [53888] (4 proteins)
further duplication: composed of two two-domain lobes
Protein Lactoferrin [53889] (6 species)

Species:

Camel (Camelus dromedarius) [TaxId:9838] [64195] (2 PDB entries)
1. Domains for 1dtz:
  1. Domain d1dtza1: 1dtz A:1-333 [59134]
  2. Domain d1dtza2: 1dtz A:334-689 [59135]
2. Domains for 1i6q:
  1. Domain d1i6qa1: 1i6q A:1-333 [66043]
    complexed with co3, fe
  2. Domain d1i6qa2: 1i6q A:334-689 [66044]
    complexed with co3, fe
Cow (Bos taurus) [TaxId:9913] [53891] (20 PDB entries)
1. Domains for 1blf:
  1. Domain d1blfa1: 1blf A:5-333 [35859]
    complexed with co3, fe, nag
  2. Domain d1blfa2: 1blf A:334-689 [35860]
    complexed with co3, fe, nag
2. Domain for 1nkx:
  - Domain d1nkxa_: 1nkx A: [91943]
    C-terminal lobe
    complexed with co3, fe, nag, zn
3. Domain for 1sdx:
  - Domain d1sdx.1: 1sdx A:,E: [98812]
    C-terminal lobe
    complexed with co3, so4, zn
4. Domain for 2alt:
  - Domain d2alta_: 2alt A: [303510]
    automated match to d1nkxa_
    complexed with co3, fe, imn, nag, so4, zn
5. Domain for 2alu:
  - Domain d2alua_: 2alu A: [126981]
    automated match to d1nkxa_
    complexed with co3, fe, nag, so4, zn
6. Domain for 2ays:
  - Domain d2aysa_: 2ays A: [127570]
    automated match to d1nkxa_
    complexed with a2g, co3, fe, nag, so4, zn
7. Domain for 2b6d:
  - Domain d2b6da_: 2b6d A: [303550]
    automated match to d4oqoa_
    complexed with co3, dif, eoh, fe, so4, zn
8. Domain for 2g5j:
  - Domain d2g5ja_: 2g5j A: [303921]
    automated match to d4oqoa_
    complexed with ain, co3, eoh, fe, so4, zn
9. Domain for 2q8j:
  - Domain d2q8ja_: 2q8j A: [139890]
    automated match to d1nkxa_
    complexed with bma, co3, fe, m2p, nag, so4, zn
10. Domain for 2qje:
  - Domain d2qjea_: 2qje A: [150829]
    automated match to d1nkxa_
    complexed with co3, fe, nag, so4, zn
11. Domain for 2qz1:
  - Domain d2qz1a_: 2qz1 A: [304451]
    automated match to d4oqoa_
    complexed with co3, fe, ibp, so4, zn
12. Domain for 3fkx:
  - Domain d3fkxa_: 3fkx A: [305389]
    automated match to d4oqoa_
    complexed with co3, fe, ibp, so4, zn
13. Domain for 3hwq:
  - Domain d3hwqa_: 3hwq A: [305533]
    automated match to d4oqoa_
    complexed with co3, fe, ibp, so4, zn
14. Domain for 3hwv:
  - Domain d3hwva_: 3hwv A: [305534]
    automated match to d4oqoa_
    complexed with co3, dif, eoh, fe, so4, zn
15. Domain for 3hwy:
  - Domain d3hwya_: 3hwy A: [305535]
    automated match to d4oqoa_
    complexed with ain, co3, eoh, fe, so4, zn
16. Domain for 3hwz:
  - Domain d3hwza_: 3hwz A: [305536]
    automated match to d4oqoa_
    complexed with co3, fe, imn, nag, so4, zn
17. Domains for 4oqo:
  1. Domain d4oqoa_: 4oqo A: [237718]
    automated match to d2q8ja_
    complexed with nag
  2. Domain d4oqob_: 4oqo B: [237717]
    automated match to d2q8ja_
    complexed with nag
18. Domains for 5cry:
  1. Domain d5crya_: 5cry A: [278056]
    automated match to d1nkxa_
    complexed with bct, fe, nag
  2. Domain d5cryb_: 5cry B: [278055]
    automated match to d1nkxa_
    complexed with bct, fe, nag
19. Domains for 5hbc:
  1. Domain d5hbca_: 5hbc A: [314634]
    automated match to d1nkxa_
    complexed with bct, fe, nag
  2. Domain d5hbcb_: 5hbc B: [314688]
    automated match to d1nkxa_
    complexed with bct, fe, nag
20. Domains for 7equ:
  1. Domain d7equa_: 7equ A: [405239]
    automated match to d1nkxa_
    complexed with bct, fe, nag
  2. Domain d7equb_: 7equ B: [405289]
    automated match to d1nkxa_
    complexed with bct, fe, nag
Domestic water buffalo (Bubalus arnee bubalis) [TaxId:89462] [53892] (2 PDB entries)
1. Domains for 1biy:
  1. Domain d1biya1: 1biy A:1-333 [35863]
    complexed with co3, fe
  2. Domain d1biya2: 1biy A:334-689 [35864]
    complexed with co3, fe
2. Domains for 1ce2:
  1. Domain d1ce2a1: 1ce2 A:1-333 [35861]
    complexed with co3, fe
  2. Domain d1ce2a2: 1ce2 A:334-689 [35862]
    complexed with co3, fe
Goat (Capra hircus) [TaxId:9925] [89791] (1 PDB entry)
- Domains for 1jw1:
  1. Domain d1jw1a1: 1jw1 A:1-333 [84234]
    complexed with fe
  2. Domain d1jw1a2: 1jw1 A:334-689 [84235]
    complexed with fe
Horse (Equus caballus) [TaxId:9796] [53893] (7 PDB entries)
1. Domains for 1b1x:
  1. Domain d1b1xa1: 1b1x A:1-333 [35865]
    complexed with co3, fe
  2. Domain d1b1xa2: 1b1x A:334-689 [35866]
    complexed with co3, fe
2. Domains for 1b7u:
  1. Domain d1b7ua1: 1b7u A:1-333 [35873]
  2. Domain d1b7ua2: 1b7u A:334-689 [35874]
3. Domains for 1b7z:
  1. Domain d1b7za1: 1b7z A:1-333 [35867]
    complexed with fe, oxl
  2. Domain d1b7za2: 1b7z A:334-689 [35868]
    complexed with fe, oxl
4. Domains for 1f9b:
  1. Domain d1f9ba1: 1f9b A:1-333 [35869]
    complexed with 3id, bct, fe
  2. Domain d1f9ba2: 1f9b A:334-689 [35870]
    complexed with 3id, bct, fe
5. Domains for 1i6b:
  1. Domain d1i6ba1: 1i6b A:1-333 [66036]
  2. Domain d1i6ba2: 1i6b A:334-689 [66037]
6. Domains for 1qjm:
  1. Domain d1qjma1: 1qjm A:1-333 [35871]
    complexed with co3, sm
  2. Domain d1qjma2: 1qjm A:334-689 [35872]
    complexed with co3, sm
7. Domains for 3cr9:
  1. Domain d3cr9a1: 3cr9 A:1-333 [156943]
    automatically matched to d1b1xa1
    complexed with fe, glc
  2. Domain d3cr9a2: 3cr9 A:334-689 [156944]
    automatically matched to d1b1xa2
    complexed with fe, glc
Human (Homo sapiens) [TaxId:9606] [53890] (21 PDB entries)
1. Domains for 1b0l:
  1. Domain d1b0la1: 1b0l A:1-334 [35847]
    complexed with co3, fe
  2. Domain d1b0la2: 1b0l A:335-691 [35848]
    complexed with co3, fe
2. Domains for 1bka:
  1. Domain d1bkaa1: 1bka A:4-334 [35852]
    complexed with fe, oxl
  2. Domain d1bkaa2: 1bka A:335-691 [35853]
    complexed with fe, oxl
3. Domains for 1cb6:
  1. Domain d1cb6a1: 1cb6 A:1001-1334 [35840]
    complexed with cl
  2. Domain d1cb6a2: 1cb6 A:1335-1691 [35841]
    complexed with cl
4. Domain for 1dsn:
  - Domain d1dsna_: 1dsn A: [35837]
    complexed with co3, fe
5. Domain for 1eh3:
  - Domain d1eh3a_: 1eh3 A: [35842]
    N-terminal lobe
    complexed with co3, fe
6. Domains for 1fck:
  1. Domain d1fcka1: 1fck A:1-334 [35843]
    complexed with ce, co3
  2. Domain d1fcka2: 1fck A:335-691 [35844]
    complexed with ce, co3
7. Domain for 1h43:
  - Domain d1h43a_: 1h43 A: [76672]
    N-terminal lobe
    complexed with co3, fe
8. Domain for 1h44:
  - Domain d1h44a_: 1h44 A: [76673]
    N-terminal lobe
    complexed with co3, fe
9. Domain for 1h45:
  - Domain d1h45a_: 1h45 A: [76674]
    N-terminal lobe
    complexed with co3, fe
10. Domain for 1hse:
  - Domain d1hsea_: 1hse A: [35849]
    complexed with co3, fe
11. Domains for 1l5t:
  1. Domain d1l5ta_: 1l5t A: [73601]
    N-terminal lobe
    mutant
  2. Domain d1l5tb_: 1l5t B: [73602]
    N-terminal lobe
    mutant
12. Domains for 1lcf:
  1. Domain d1lcfa1: 1lcf A:1-334 [35838]
    complexed with co3, cu, nag, oxl
  2. Domain d1lcfa2: 1lcf A:335-691 [35839]
    complexed with co3, cu, nag, oxl
13. Domain for 1lct:
  - Domain d1lcta_: 1lct A: [35836]
    N-terminal lobe
    complexed with co3, fe
14. Domains for 1lfg:
  1. Domain d1lfga1: 1lfg A:1-334 [35845]
    complexed with co3, fe
  2. Domain d1lfga2: 1lfg A:335-691 [35846]
    complexed with co3, fe
15. Domains for 1lfh:
  1. Domain d1lfha1: 1lfh A:1-334 [35856]
    complexed with cl
  2. Domain d1lfha2: 1lfh A:335-691 [35857]
    complexed with cl
16. Domains for 1lfi:
  1. Domain d1lfia1: 1lfi A:1-334 [35850]
    complexed with co3, cu
  2. Domain d1lfia2: 1lfi A:335-691 [35851]
    complexed with co3, cu
17. Domain for 1lgb:
  - Domain d1lgbc_: 1lgb C: [35858]
    Other proteins in same PDB: d1lgb.1
    N2-fragment (one domain fragment)
    complexed with ca, mn
    fragment; missing more than one-third of the common structure and/or sequence
18. Domains for 1n76:
  1. Domain d1n76a1: 1n76 A:2-334 [80226]
    complexed with co3, fe, na
  2. Domain d1n76a2: 1n76 A:335-691 [80227]
    complexed with co3, fe, na
19. Domains for 1sqy:
  1. Domain d1sqya1: 1sqy A:1-334 [98973]
    complexed with co3, fe
  2. Domain d1sqya2: 1sqy A:335-691 [98974]
    complexed with co3, fe
20. Domain for 1vfd:
  - Domain d1vfda_: 1vfd A: [35855]
    complexed with co3, fe; mutant
21. Domain for 1vfe:
  - Domain d1vfea_: 1vfe A: [35854]
    complexed with co3, fe; mutant