Lineage for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 843892Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 843893Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (5 families) (S)
    the constituent families form similar dimers
  5. 843894Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins)
    the active site is between the two identical subunits

Proteins:

  1. 8438953-isopropylmalate dehydrogenase, IPMDH [53661] (9 species)
    1. 843896Species Bacillus coagulans [TaxId:1398] [53664] (2 PDB entries)
    2. 843901Species Chimera (Thermus thermophilus) and (Bacillus subtilis) [TaxId:274] [53663] (2 PDB entries)
    3. 843904Species Escherichia coli [TaxId:562] [53667] (1 PDB entry)
    4. 843907Species Mycobacterium tuberculosis [TaxId:1773] [117725] (2 PDB entries)
      Uniprot P95313
    5. 843916Species Salmonella typhimurium [TaxId:90371] [53666] (1 PDB entry)
    6. 843919Species Sulfolobus tokodaii [TaxId:111955] [117724] (1 PDB entry)
      Uniprot P50455
    7. 843922Species Thermotoga maritima [TaxId:2336] [110714] (1 PDB entry)
      Uniprot Q9WZ26
    8. 843924Species Thermus thermophilus [TaxId:274] [53662] (14 PDB entries)
    9. 843947Species Thiobacillus ferrooxidans [TaxId:920] [53665] (1 PDB entry)
  2. 843950Isocitrate dehydrogenase, ICDH [53668] (2 species)
    1. 843951Species Bacillus subtilis [TaxId:1423] [64171] (1 PDB entry)
    2. 843954Species Escherichia coli [TaxId:562] [53669] (26 PDB entries)
  3. 843981NADP-dependent isocitrate dehydrogenase [82524] (2 species)
    1. 843982Species Human (Homo sapiens) [TaxId:9606] [110715] (2 PDB entries)
      Uniprot O75874
    2. 843989Species Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)

More info for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases: