Lineage for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

  1. Root: SCOP 1.69
  2. 473232Class c: Alpha and beta proteins (a/b) [51349] (136 folds)
  3. 493010Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 493011Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (5 families) (S)
    the constituent families form similar dimers
  5. 493012Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins)
    the active site is between the two identical subunits

Proteins:

  1. 4930133-isopropylmalate dehydrogenase, IPMDH [53661] (7 species)
    1. 493014Species Bacillus coagulans [TaxId:1398] [53664] (1 PDB entry)
    2. 493017Species Chimera (Thermus thermophilus) and (Bacillus subtilis) [TaxId:274] [53663] (2 PDB entries)
    3. 493020Species Escherichia coli [TaxId:562] [53667] (1 PDB entry)
    4. 493023Species Salmonella typhimurium [TaxId:90371] [53666] (1 PDB entry)
    5. 493026Species Thermotoga maritima [TaxId:243274] [110714] (1 PDB entry)
    6. 493028Species Thermus thermophilus [TaxId:274] [53662] (14 PDB entries)
    7. 493051Species Thiobacillus ferrooxidans [TaxId:920] [53665] (1 PDB entry)
  2. 493054Isocitrate dehydrogenase, ICDH [53668] (2 species)
    1. 493055Species Bacillus subtilis [TaxId:1423] [64171] (1 PDB entry)
    2. 493058Species Escherichia coli [TaxId:562] [53669] (26 PDB entries)
  3. 493085NADP-dependent isocitrate dehydrogenase [82524] (2 species)
    1. 493086Species Human (Homo sapiens) [TaxId:9606] [110715] (2 PDB entries)
    2. 493093Species Pig (Sus scrofa) [TaxId:9823] [82525] (2 PDB entries)

More info for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases

Timeline for Family c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases: