Lineage for Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like

  1. Root: SCOP 1.69
  2. 473232Class c: Alpha and beta proteins (a/b) [51349] (136 folds)
  3. 493010Fold c.77: Isocitrate/Isopropylmalate dehydrogenase-like [53658] (1 superfamily)
    consists of two intertwined (sub)domains related by pseudo dyad; duplication
    3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest
  4. 493011Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like [53659] (5 families) (S)
    the constituent families form similar dimers

Families:

  1. 493012c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins)
    the active site is between the two identical subunits
  2. 493100c.77.1.2: Monomeric isocitrate dehydrogenase [82526] (1 protein)
    the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion
  3. 493107c.77.1.3: PdxA-like [102656] (1 protein)
    Pfam 04166; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PlsX-like and phosphotransacetylase families
  4. 493121c.77.1.4: PlsX-like [102660] (1 protein)
    Pfam 02504; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and phosphotransacetylase families
  5. 493129c.77.1.5: Phosphotransacetylase [102663] (2 proteins)
    Pfam 01515; contains extra beta-alpha unit between strands 2 and 3; closer relationships to the PdxA-like and PlsX-like families

More info for Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like

Timeline for Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenase-like: