Class c: Alpha and beta proteins (a/b) [51349] (117 folds) |
Fold c.77: Isocitrate/Isopropylmalate dehydrogenases [53658] (1 superfamily) consists of two intertwined (sub)domains related by pseudodyad; duplication 3 layers: a/b/a; single mixed beta-sheet of 10 strands, order 213A945867 (A=10); strands from 5 to 9 are antiparallel to the rest |
Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenases [53659] (2 families) |
c.77.1.1: Dimeric isocitrate & isopropylmalate dehydrogenases [53660] (3 proteins) the active site is between the two identical subunits |
c.77.1.2: Monomeric isocitrate dehydrogenase [82526] (1 protein) the active site is contained within one subunit between the canonical ICDH fold and a large insert domain that itself is a probable rudiment form of ICDH fold resulted from duplication, domain swapping and deletion |
Timeline for Superfamily c.77.1: Isocitrate/Isopropylmalate dehydrogenases: