SCOPe 2.05: Family c.72.2.1: MurCDEF

Lineage for Family c.72.2.1: MurCDEF

1. Root: SCOPe 2.05

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.72: Ribokinase-like [53612] (3 superfamilies)
   core: 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
   potential superfamily: members of this fold have similar functions but different ATP-binding sites

4. Superfamily c.72.2: MurD-like peptide ligases, catalytic domain [53623] (3 families)
   has extra strand located between strands 1 and 2

5. Family c.72.2.1: MurCDEF [53624] (5 proteins)
   automatically mapped to Pfam PF08245

Proteins:

1. UDP-murNac-tripeptide D-alanyl-D-alanine-adding enzyme MurF [53627] (1 species)

   • Species Escherichia coli [TaxId:562] [53628] (1 PDB entry)

2. UDP-N-acetylmuramate-alanine ligase MurC [82520] (2 species)

   1. Species Haemophilus influenzae [TaxId:727] [89776] (4 PDB entries)

   2. Species Thermotoga maritima [TaxId:2336] [82521] (1 PDB entry)
      TM0231

3. UDP-N-acetylmuramoyl-L-alanine:D-glutamate ligase MurD [53625] (1 species)

   • Species Escherichia coli [TaxId:562] [53626] (6 PDB entries)

4. UDP-N-acetylmuramyl tripeptide synthetase MurE [64150] (1 species)

   • Species Escherichia coli [TaxId:562] [64151] (1 PDB entry)

5. automated matches [254549] (2 species)
   not a true protein

   1. Species Escherichia coli [TaxId:562] [255258] (8 PDB entries)

   2. Species Escherichia coli [TaxId:668369] [255650] (2 PDB entries)

More info for Family c.72.2.1: MurCDEF

Timeline for Family c.72.2.1: MurCDEF:

• Family c.72.2.1: MurCDEF first appeared (with stable ids) in SCOP 1.55, called Family c.72.2.1: MurD/MurF
  
• Family c.72.2.1: MurCDEF appears in SCOPe 2.04
  
• Family c.72.2.1: MurCDEF appears in SCOPe 2.06
  
• Family c.72.2.1: MurCDEF appears in the current release, SCOPe 2.08