SCOPe 2.06: Family c.72.1.2: Thiamin biosynthesis kinases

Lineage for Family c.72.1.2: Thiamin biosynthesis kinases

1. Root: SCOPe 2.06

2. Class c: Alpha and beta proteins (a/b) [51349] (148 folds)

3. Fold c.72: Ribokinase-like [53612] (3 superfamilies)
   core: 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 21345678, strand 7 is antiparallel to the rest
   potential superfamily: members of this fold have similar functions but different ATP-binding sites

4. Superfamily c.72.1: Ribokinase-like [53613] (6 families)
   has extra strand located between strands 2 and 3

5. Family c.72.1.2: Thiamin biosynthesis kinases [53620] (2 proteins)

Proteins:

1. 4-amino-5-hydroxymethyl-2-methylpyrimidine phosphate kinase (HMP-phosphate kinase, ThiD) [69589] (2 species)

   1. Species Salmonella typhimurium [TaxId:90371] [69590] (2 PDB entries)

   2. Species Thermus thermophilus [TaxId:274] [89775] (1 PDB entry)

2. Hydroxyethylthiazole kinase (THZ kinase, ThiK) [53621] (2 species)

   1. Species Bacillus subtilis [TaxId:1423] [53622] (5 PDB entries)

   2. Species Pyrococcus horikoshii [TaxId:53953] [102637] (2 PDB entries)

More info for Family c.72.1.2: Thiamin biosynthesis kinases

Timeline for Family c.72.1.2: Thiamin biosynthesis kinases:

• Family c.72.1.2: Thiamin biosynthesis kinases first appeared (with stable ids) in SCOP 1.55, called Family c.72.1.2: Hydroxyethylthiazole kinase (thz kinase)
  
• Family c.72.1.2: Thiamin biosynthesis kinases appears in SCOPe 2.05
  
• Family c.72.1.2: Thiamin biosynthesis kinases appears in SCOPe 2.07
  
• Family c.72.1.2: Thiamin biosynthesis kinases appears in the current release, SCOPe 2.08