Lineage for Protein: Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain

  1. Root: SCOP 1.75
  2. 814173Class c: Alpha and beta proteins (a/b) [51349] (147 folds)
  3. 843142Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily)
    3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest
  4. 843143Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families) (S)
  5. 843144Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins)
  6. 843145Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species)

Species:

  1. 843146Cryptosporidium hominis [TaxId:237895] [102636] (3 PDB entries)
    Uniprot Q5CGA3 Q27552
    1. Domains for 1qzf:
      1. 843152Domain d1qzfa1: 1qzf A:3-180 [96633]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
      2. 843153Domain d1qzfb1: 1qzf B:3-180 [96635]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
      3. 843154Domain d1qzfc1: 1qzf C:3-180 [96637]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
      4. 843155Domain d1qzfd1: 1qzf D:3-180 [96639]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
      5. 843156Domain d1qzfe1: 1qzf E:3-180 [96641]
        Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2
        complexed with cb3, fol, ndp, ump
    2. Domains for 1sej:
      1. 843147Domain d1seja1: 1sej A:3-180 [105455]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
      2. 843148Domain d1sejb1: 1sej B:3-180 [105457]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
      3. 843149Domain d1sejc1: 1sej C:3-180 [105459]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
      4. 843150Domain d1sejd1: 1sej D:3-180 [105461]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
      5. 843151Domain d1seje1: 1sej E:3-180 [105463]
        Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2
        complexed with f89, ndp, ump
    3. Domains for 2oip:
      1. 843157Domain d2oipa1: 2oip A:3-180 [148784]
        Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2
        automatically matched to d1qzfa1
        complexed with cb3, mtx, ndp, ump; mutant
      2. 843158Domain d2oipb1: 2oip B:3-180 [148786]
        Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2
        automatically matched to d1qzfa1
        complexed with cb3, mtx, ndp, ump; mutant
      3. 843159Domain d2oipc1: 2oip C:3-180 [148788]
        Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2
        automatically matched to d1qzfa1
        complexed with cb3, mtx, ndp, ump; mutant
      4. 843160Domain d2oipd1: 2oip D:3-180 [148790]
        Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2
        automatically matched to d1qzfa1
        complexed with cb3, mtx, ndp, ump; mutant
      5. 843161Domain d2oipe1: 2oip E:3-180 [148792]
        Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2
        automatically matched to d1qzfa1
        complexed with cb3, mtx, ndp, ump; mutant
  2. 843162Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (3 PDB entries)
    1. Domains for 1j3i:
      1. 843165Domain d1j3ia_: 1j3i A: [84062]
        Other proteins in same PDB: d1j3ic_, d1j3id_
      2. 843166Domain d1j3ib_: 1j3i B: [84063]
        Other proteins in same PDB: d1j3ic_, d1j3id_
        complexed with ndp, ump, wra
    2. Domains for 1j3j:
      1. 843167Domain d1j3ja_: 1j3j A: [84066]
        Other proteins in same PDB: d1j3jc_, d1j3jd_
      2. 843168Domain d1j3jb_: 1j3j B: [84067]
        Other proteins in same PDB: d1j3jc_, d1j3jd_
        complexed with cp6, ndp, ump; mutant
    3. Domains for 1j3k:
      1. 843163Domain d1j3ka_: 1j3k A: [84070]
        Other proteins in same PDB: d1j3kc_, d1j3kd_
      2. 843164Domain d1j3kb_: 1j3k B: [84071]
        Other proteins in same PDB: d1j3kc_, d1j3kd_
        complexed with ndp, ump, wra; mutant

More info for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases

Timeline for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases: