Class c: Alpha and beta proteins (a/b) [51349] (147 folds) |
Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily) 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest |
Superfamily c.71.1: Dihydrofolate reductase-like [53597] (2 families) |
Family c.71.1.1: Dihydrofolate reductases [53598] (3 proteins) |
Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain [53610] (2 species) |
Cryptosporidium hominis [TaxId:237895] [102636] (3 PDB entries) Uniprot Q5CGA3 Q27552 |
Domain d1qzfa1: 1qzf A:3-180 [96633] Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2 |
Domain d1qzfb1: 1qzf B:3-180 [96635] Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2 |
Domain d1qzfc1: 1qzf C:3-180 [96637] Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2 |
Domain d1qzfd1: 1qzf D:3-180 [96639] Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2 |
Domain d1qzfe1: 1qzf E:3-180 [96641] Other proteins in same PDB: d1qzfa2, d1qzfb2, d1qzfc2, d1qzfd2, d1qzfe2 complexed with cb3, fol, ndp, ump |
Domain d1seja1: 1sej A:3-180 [105455] Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2 |
Domain d1sejb1: 1sej B:3-180 [105457] Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2 |
Domain d1sejc1: 1sej C:3-180 [105459] Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2 |
Domain d1sejd1: 1sej D:3-180 [105461] Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2 |
Domain d1seje1: 1sej E:3-180 [105463] Other proteins in same PDB: d1seja2, d1sejb2, d1sejc2, d1sejd2, d1seje2 complexed with f89, ndp, ump |
Domain d2oipa1: 2oip A:3-180 [148784] Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2 automatically matched to d1qzfa1 complexed with cb3, mtx, ndp, ump; mutant |
Domain d2oipb1: 2oip B:3-180 [148786] Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2 automatically matched to d1qzfa1 complexed with cb3, mtx, ndp, ump; mutant |
Domain d2oipc1: 2oip C:3-180 [148788] Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2 automatically matched to d1qzfa1 complexed with cb3, mtx, ndp, ump; mutant |
Domain d2oipd1: 2oip D:3-180 [148790] Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2 automatically matched to d1qzfa1 complexed with cb3, mtx, ndp, ump; mutant |
Domain d2oipe1: 2oip E:3-180 [148792] Other proteins in same PDB: d2oipa2, d2oipb2, d2oipc2, d2oipd2, d2oipe2 automatically matched to d1qzfa1 complexed with cb3, mtx, ndp, ump; mutant |
Malaria parasite (Plasmodium falciparum) [TaxId:5833] [88963] (3 PDB entries) |
Domain d1j3ia_: 1j3i A: [84062] Other proteins in same PDB: d1j3ic_, d1j3id_ |
Domain d1j3ib_: 1j3i B: [84063] Other proteins in same PDB: d1j3ic_, d1j3id_ complexed with ndp, ump, wra |
Domain d1j3ja_: 1j3j A: [84066] Other proteins in same PDB: d1j3jc_, d1j3jd_ |
Domain d1j3jb_: 1j3j B: [84067] Other proteins in same PDB: d1j3jc_, d1j3jd_ complexed with cp6, ndp, ump; mutant |
Domain d1j3ka_: 1j3k A: [84070] Other proteins in same PDB: d1j3kc_, d1j3kd_ |
Domain d1j3kb_: 1j3k B: [84071] Other proteins in same PDB: d1j3kc_, d1j3kd_ complexed with ndp, ump, wra; mutant |
Timeline for Protein Bifunctional enzyme dihydrofolate reductase-thymidylate synthase, DFR domain from c.71.1.1: Dihydrofolate reductases: