![]() | Class c: Alpha and beta proteins (a/b) [51349] (148 folds) |
![]() | Fold c.71: Dihydrofolate reductase-like [53596] (1 superfamily) 3 layers: a/b/a; mixed beta-sheet of 8 strands, order 34251687; strand 8 is antiparallel to the rest |
![]() | Superfamily c.71.1: Dihydrofolate reductase-like [53597] (3 families) ![]() |
![]() | Family c.71.1.1: Dihydrofolate reductases [53598] (4 proteins) |
![]() | Protein Dihydrofolate reductases, eukaryotic type [53605] (7 species) |
![]() | Candida glabrata [TaxId:284593] [237803] (4 PDB entries) |
![]() | Domain d3ro9a1: 3ro9 A:3-217 [200501] Other proteins in same PDB: d3ro9a2, d3ro9b2 automated match to d3ro9b_ complexed with 06u, ndp |
![]() | Domain d3ro9b1: 3ro9 B:3-217 [193189] Other proteins in same PDB: d3ro9a2, d3ro9b2 automated match to d3csea_ complexed with 06u, ndp |
![]() | Domain d3roaa1: 3roa A:3-217 [215949] Other proteins in same PDB: d3roaa2, d3roab2 automated match to d3ro9b_ complexed with 06v, cl, ndp |
![]() | Domain d3roab1: 3roa B:3-217 [215950] Other proteins in same PDB: d3roaa2, d3roab2 automated match to d3ro9b_ complexed with 06v, cl, ndp |
![]() | Domain d4h98a1: 4h98 A:4-217 [202388] Other proteins in same PDB: d4h98a2, d4h98b2 automated match to d4h98b_ complexed with 14q, ndp |
![]() | Domain d4h98b1: 4h98 B:4-217 [196719] Other proteins in same PDB: d4h98a2, d4h98b2 automated match to d3csea_ complexed with 14q, ndp |
![]() | Domain d4hoga1: 4hog A:3-217 [237804] Other proteins in same PDB: d4hoga2, d4hogb2 automated match to d3csea_ complexed with 18h, cl, ndp |
![]() | Domain d4hogb1: 4hog B:3-217 [237806] Other proteins in same PDB: d4hoga2, d4hogb2 automated match to d3csea_ complexed with 18h, cl, ndp |
![]() | Candida glabrata [TaxId:5478] [188672] (1 PDB entry) |
![]() | Domain d3csea1: 3cse A:3-217 [173432] Other proteins in same PDB: d3csea2, d3cseb2 automated match to d1ai9a_ complexed with n22, ndp |
![]() | Domain d3cseb1: 3cse B:3-217 [173433] Other proteins in same PDB: d3csea2, d3cseb2 automated match to d1ai9a_ complexed with n22, ndp |
![]() | Chicken (Gallus gallus) [TaxId:9031] [53606] (8 PDB entries) |
![]() | Domain d1dr1a_: 1dr1 A: [34896] complexed with ca, hbi, nap |
![]() | Domain d1dr2a_: 1dr2 A: [34898] complexed with ca, tap |
![]() | Domain d1dr3a_: 1dr3 A: [34897] complexed with ca, hbi, tap |
![]() | Domain d1dr4a_: 1dr4 A: [34900] complexed with ca, hbi, hg, nap |
![]() | Domain d1dr5a_: 1dr5 A: [34901] complexed with ca, hg, nap |
![]() | Domain d1dr6a_: 1dr6 A: [34899] complexed with ca, hbi, mbo, nap |
![]() | Domain d1dr7a_: 1dr7 A: [34902] complexed with ca, mbo, nap |
![]() | Domain d8dfra_: 8dfr A: [34895] complexed with ca, ndp |
![]() | Fungus (Pneumocystis carinii) [TaxId:4754] [53608] (25 PDB entries) |
![]() | Domain d1cd2a_: 1cd2 A: [34919] complexed with fol, nap |
![]() | Domain d1d8ra_: 1d8r A: [302304] automated match to d1vj3a_ complexed with ndp, tab |
![]() | Domain d1daja_: 1daj A: [34921] complexed with mot, ndp |
![]() | Domain d1dyra_: 1dyr A: [34916] complexed with ndp, top |
![]() | Domain d1e26a_: 1e26 A: [59160] complexed with gpb, nap |
![]() | Domain d1klka_: 1klk A: [77439] complexed with ndp, pmd |
![]() | Domain d1ly3a_: 1ly3 A: [74337] complexed with cog, nap |
![]() | Domain d1ly4a_: 1ly4 A: [74338] complexed with coq, nap |
![]() | Domain d1s3ya_: 1s3y A: [98469] complexed with nap, tqt |
![]() | Domain d1vj3a_: 1vj3 A: [100798] complexed with ndp, tab |
![]() | Domain d2cd2a_: 2cd2 A: [34918] complexed with fol, nap |
![]() | Domain d2fzha_: 2fzh A: [134447] automated match to d1cd2a_ complexed with dh1, ndp |
![]() | Domain d2fzia_: 2fzi A: [134448] automated match to d1cd2a_ complexed with dh3, ndp |
![]() | Domain d3cd2a_: 3cd2 A: [34922] complexed with mtx, nap |
![]() | Domain d3nz6x_: 3nz6 X: [182651] automated match to d1cd2a_ complexed with d2j, ndp |
![]() | Domain d3nz9x_: 3nz9 X: [182652] automated match to d1cd2a_ complexed with d2k, ndp |
![]() | Domain d3nzax_: 3nza X: [182653] automated match to d1cd2a_ complexed with cl, d2k, ndp |
![]() | Domain d3nzbx_: 3nzb X: [182654] automated match to d1cd2a_ complexed with d2n, ndp |
![]() | Domain d3nzcx_: 3nzc X: [182655] automated match to d1cd2a_ complexed with d2o, gol, po4 |
![]() | Domain d3td8a_: 3td8 A: [195600] automated match to d3nzbx_ complexed with d2r, ndp |
![]() | Domain d4cd2a_: 4cd2 A: [34917] complexed with fol |
![]() | Domain d4ixed_: 4ixe D: [197193] automated match to d3nzbx_ complexed with ixe, ndp |
![]() | Domain d4ixfx_: 4ixf X: [197194] automated match to d3nzbx_ complexed with ixf, ndp |
![]() | Domain d4ixgx_: 4ixg X: [197103] automated match to d3nzbx_ complexed with ixg, ndp |
![]() | Domain d4qjzd_: 4qjz D: [273656] automated match to d1ly3a_ complexed with 33m, ndp |
![]() | Human (Homo sapiens) [TaxId:9606] [53607] (79 PDB entries) |
![]() | Domain d1boza_: 1boz A: [34905] complexed with ndp, prd |
![]() | Domain d1dhfa_: 1dhf A: [34910] complexed with fol |
![]() | Domain d1dhfb_: 1dhf B: [34911] complexed with fol |
![]() | Domain d1dlra_: 1dlr A: [34909] complexed with mxa, ndp |
![]() | Domain d1dlsa_: 1dls A: [34906] complexed with mtx, ndp |
![]() | Domain d1drfa_: 1drf A: [34907] complexed with fol, so4 |
![]() | Domain d1hfpa_: 1hfp A: [34904] complexed with mot, ndp |
![]() | Domain d1hfqa_: 1hfq A: [34903] complexed with mot, ndp |
![]() | Domain d1hfra_: 1hfr A: [34908] complexed with mot, ndp |
![]() | Domain d1kmsa_: 1kms A: [72756] complexed with lih, ndp, so4 |
![]() | Domain d1kmva_: 1kmv A: [72757] complexed with dms, lii, ndp, so4 |
![]() | Domain d1mvsa_: 1mvs A: [85156] complexed with dtm, so4 |
![]() | Domain d1mvta_: 1mvt A: [85157] complexed with dtm, so4 |
![]() | Domain d1ohja_: 1ohj A: [34914] complexed with cop, ndp |
![]() | Domain d1ohka_: 1ohk A: [34915] complexed with cop, ndp |
![]() | Domain d1pd8a_: 1pd8 A: [94515] complexed with co4, ndp |
![]() | Domain d1pd9a_: 1pd9 A: [94516] complexed with co4, so4 |
![]() | Domain d1pdba_: 1pdb A: [94517] |
![]() | Domain d1s3ua_: 1s3u A: [98464] complexed with so4, tqd |
![]() | Domain d1s3va_: 1s3v A: [98465] complexed with so4, tqd |
![]() | Domain d1s3wa_: 1s3w A: [98466] complexed with nap, tqt |
![]() | Domain d1u71a_: 1u71 A: [161805] automated match to d1dlra_ complexed with mxa, so4 |
![]() | Domain d1u72a_: 1u72 A: [119614] automated match to d1drf__ complexed with mtx, ndp |
![]() | Domain d1yhoa_: 1yho A: [123179] automated match to d1kmva_ complexed with ndp, trr |
![]() | Domain d2c2sa_: 2c2s A: [129682] automated match to d1drf__ complexed with 34b, gol, ndp |
![]() | Domain d2c2sb_: 2c2s B: [129683] automated match to d1drf__ complexed with 34b, gol, ndp |
![]() | Domain d2c2ta_: 2c2t A: [129684] automated match to d1drf__ complexed with 39b, 39e, gol, ndp |
![]() | Domain d2c2tb_: 2c2t B: [129685] automated match to d1drf__ complexed with 39b, 39e, gol, ndp |
![]() | Domain d2dhfa_: 2dhf A: [34912] complexed with dzf |
![]() | Domain d2dhfb_: 2dhf B: [34913] complexed with dzf |
![]() | Domain d2w3aa_: 2w3a A: [169035] automated match to d1dlra_ complexed with gol, ndp, so4, top |
![]() | Domain d2w3ab_: 2w3a B: [169036] automated match to d1dlra_ complexed with gol, ndp, so4, top |
![]() | Domain d2w3ba_: 2w3b A: [169037] automated match to d1dlra_ complexed with fol, k, ndp, vg9 |
![]() | Domain d2w3bb_: 2w3b B: [169038] automated match to d1dlra_ complexed with fol, k, ndp, vg9 |
![]() | Domain d2w3ma_: 2w3m A: [169045] automated match to d1dlra_ complexed with fol, ndp |
![]() | Domain d2w3mb_: 2w3m B: [169046] automated match to d1dlra_ complexed with fol, ndp |
![]() | Domain d3eiga_: 3eig A: [174950] automated match to d1boza_ complexed with cd, mtx, so4; mutant |
![]() | Domain d3f8ya_: 3f8y A: [175577] automated match to d1dlra_ complexed with dh1, ndp, so4; mutant |
![]() | Domain d3f8za_: 3f8z A: [175578] automated match to d1dlra_ complexed with dh1, ndp, so4; mutant |
![]() | Domain d3f91a_: 3f91 A: [175587] automated match to d1drfa_ complexed with dh1, ndp, so4; mutant |
![]() | Domain d3fs6a_: 3fs6 A: [176013] automated match to d1dlra_ complexed with dh1, ndp; mutant |
![]() | Domain d3ghca_: 3ghc A: [176635] automated match to d1dlra_ complexed with ghc, ndp, so4 |
![]() | Domain d3ghva_: 3ghv A: [176654] automated match to d1drfa_ complexed with ghc, gol, ndp, so4; mutant |
![]() | Domain d3ghwa_: 3ghw A: [176655] automated match to d1drfa_ complexed with ghw, ndp, so4 |
![]() | Domain d3gi2a_: 3gi2 A: [176659] automated match to d1dlra_ complexed with ghw, ndp; mutant |
![]() | Domain d3gyfa_: 3gyf A: [177093] automated match to d1dlra_ complexed with 51p, ndp, so4 |
![]() | Domain d3l3ra_: 3l3r A: [179914] automated match to d1drfa_ complexed with ndp, oag, so4; mutant |
![]() | Domain d3ntza_: 3ntz A: [182542] automated match to d1drfa_ complexed with 3tz, ndp, so4 |
![]() | Domain d3nu0a_: 3nu0 A: [182543] automated match to d1drfa_ complexed with 3tu, ndp, so4 |
![]() | Domain d3nxoa_: 3nxo A: [182611] automated match to d1dlra_ complexed with d2b, ndp, so4 |
![]() | Domain d3nxra_: 3nxr A: [182612] automated match to d1drfa_ complexed with d2d, ndp, so4 |
![]() | Domain d3nxta_: 3nxt A: [182614] automated match to d1drfa_ complexed with d2e, ndp, so4 |
![]() | Domain d3nxva_: 3nxv A: [182617] automated match to d1drfa_ complexed with d2f, ndp, so4 |
![]() | Domain d3nxxa_: 3nxx A: [182618] automated match to d1drfa_ complexed with d2d, ndp |
![]() | Domain d3nxya_: 3nxy A: [182619] automated match to d1drfa_ complexed with d2h, ndp, so4 |
![]() | Domain d3nzda_: 3nzd A: [182656] automated match to d1drfa_ complexed with d2q, ndp |
![]() | Domain d3oafa_: 3oaf A: [196276] automated match to d3f91a_ complexed with oag, so4; mutant |
![]() | Domain d3s7aa_: 3s7a A: [185310] automated match to d1drfa_ complexed with 684, so4 |
![]() | Domain d4ddra_: 4ddr A: [194328] automated match to d1kmva_ complexed with mmv, ndp |
![]() | Domain d4g95a_: 4g95 A: [236322] automated match to d1kmva_ complexed with oag, so4 |
![]() | Domain d4kaka_: 4kak A: [228206] automated match to d1kmva_ complexed with 06u, ca, eoh, ndp |
![]() | Domain d4kakb_: 4kak B: [228207] automated match to d1kmva_ complexed with 06u, ca, eoh, ndp |
![]() | Domain d4kbna_: 4kbn A: [228209] automated match to d1kmva_ complexed with 25u, cl, eoh, mg, ndp, nh4, sr |
![]() | Domain d4kbnb_: 4kbn B: [228208] automated match to d1kmva_ complexed with 25u, cl, eoh, mg, ndp, nh4, sr |
![]() | Domain d4kd7a_: 4kd7 A: [228211] automated match to d1kmva_ complexed with 9dr, ndp, so4 |
![]() | Domain d4kd7b_: 4kd7 B: [228210] automated match to d1kmva_ complexed with 9dr, ndp, so4 |
![]() | Domain d4keba_: 4keb A: [228213] automated match to d1kmva_ complexed with 1qz, fol, ndp |
![]() | Domain d4kebb_: 4keb B: [228212] automated match to d1kmva_ complexed with 1qz, fol, ndp |
![]() | Domain d4kfja_: 4kfj A: [228220] automated match to d1kmva_ complexed with 1r0, cl, eoh, fol, mg, ndp |
![]() | Domain d4kfjb_: 4kfj B: [228221] automated match to d1kmva_ complexed with 1r0, cl, eoh, fol, mg, ndp |
![]() | Domain d4m6ja_: 4m6j A: [228387] automated match to d1mvta_ complexed with ndp |
![]() | Domain d4m6ka_: 4m6k A: [228386] automated match to d1mvta_ complexed with fol, gol, nap |
![]() | Domain d4m6la_: 4m6l A: [228388] automated match to d1mvta_ complexed with 21v, dtt, nap, so4 |
![]() | Domain d4qhva_: 4qhv A: [273654] automated match to d1kmva_ complexed with ixf, ndp, so4 |
![]() | Domain d4qjca_: 4qjc A: [273655] automated match to d1kmva_ complexed with ixe, ndp |
![]() | Domain d5hpba_: 5hpb A: [328969] automated match to d1kmva_ complexed with 63w, ndp, so4 |
![]() | Domain d5hqya_: 5hqy A: [328941] automated match to d1kmva_ complexed with 63y, ndp |
![]() | Domain d5hqza_: 5hqz A: [329015] automated match to d1kmva_ complexed with 64j, ndp |
![]() | Domain d5hsra_: 5hsr A: [329241] automated match to d1kmva_ complexed with 63y, ndp |
![]() | Domain d5hsua_: 5hsu A: [329192] automated match to d1kmva_ complexed with 63y, ndp |
![]() | Domain d5ht4a_: 5ht4 A: [329196] automated match to d1kmva_ complexed with 65j, ndp, so4 |
![]() | Domain d5ht5a_: 5ht5 A: [329240] automated match to d1kmva_ complexed with 65h, ndp |
![]() | Domain d5huia_: 5hui A: [329197] automated match to d1kmva_ complexed with 65n, ndp, so4 |
![]() | Domain d5hvba_: 5hvb A: [329195] automated match to d1kmva_ complexed with 65o, ndp |
![]() | Domain d5hvea_: 5hve A: [329274] automated match to d1kmva_ complexed with 65q, ndp |
![]() | Domain d6a7ca_: 6a7c A: [367306] automated match to d1kmva_ complexed with 9qo, ndp, so4 |
![]() | Domain d6a7ea_: 6a7e A: [367307] automated match to d1kmva_ complexed with 9qr, ndp |
![]() | Domain d6dava_: 6dav A: [352099] automated match to d1mvta_ complexed with edo, g3v, nap |
![]() | Domain d6davb_: 6dav B: [352056] automated match to d1mvta_ complexed with edo, g3v, nap |
![]() | Domain d6de4a_: 6de4 A: [352404] automated match to d1kmva_ complexed with ca, cl, eoh, g6y, gol, ndp, so4 |
![]() | Domain d6de4b_: 6de4 B: [352437] automated match to d1kmva_ complexed with ca, cl, eoh, g6y, gol, ndp, so4 |
![]() | Domain d6vcja_: 6vcj A: [396051] automated match to d1kmva_ complexed with fol, lg3, nap, npx |
![]() | Domain d6vcjb_: 6vcj B: [395916] automated match to d1kmva_ complexed with fol, lg3, nap, npx |
![]() | Domain d6vcjc_: 6vcj C: [395978] automated match to d1kmva_ complexed with fol, lg3, nap, npx |
![]() | Domain d6vcjd_: 6vcj D: [395988] automated match to d1kmva_ complexed with fol, lg3, nap, npx |
![]() | Domain d7esea_: 7ese A: [405303] automated match to d1kmva_ complexed with fol, nap |
![]() | Mouse (Mus musculus) [TaxId:10090] [187727] (6 PDB entries) |
![]() | Domain d1u70a_: 1u70 A: [161804] automated match to d1dlsa_ complexed with mtx, ndp |
![]() | Domain d2fzja_: 2fzj A: [164523] automated match to d1drfa_ complexed with dh3, ndp |
![]() | Domain d3d80a_: 3d80 A: [173749] automated match to d1drfa_ complexed with gol, ndp, q22 |
![]() | Domain d3d84x_: 3d84 X: [173750] automated match to d1drfa_ complexed with gol, ndp |
![]() | Domain d3k45a_: 3k45 A: [179057] automated match to d1drfa_ complexed with 51p, ndp |
![]() | Domain d3k47a_: 3k47 A: [179058] automated match to d1drfa_ complexed with d09, ndp |
![]() | Yeast (Candida albicans) [TaxId:5476] [53609] (17 PDB entries) |
![]() | Domain d1ai9a_: 1ai9 A: [34925] complexed with ndp |
![]() | Domain d1ai9b_: 1ai9 B: [34926] complexed with ndp |
![]() | Domain d1aoea_: 1aoe A: [34923] complexed with gw3, ndp |
![]() | Domain d1aoeb_: 1aoe B: [34924] complexed with gw3, ndp |
![]() | Domain d1ia1a_: 1ia1 A: [62103] complexed with ndp, po4, tq3 |
![]() | Domain d1ia1b_: 1ia1 B: [62104] complexed with ndp, po4, tq3 |
![]() | Domain d1ia2a_: 1ia2 A: [62105] complexed with mes, ndp, tq4 |
![]() | Domain d1ia2b_: 1ia2 B: [62106] complexed with mes, ndp, tq4 |
![]() | Domain d1ia3a_: 1ia3 A: [62107] complexed with mes, ndp, tq5 |
![]() | Domain d1ia3b_: 1ia3 B: [62108] complexed with mes, ndp, tq5 |
![]() | Domain d1ia4a_: 1ia4 A: [62109] complexed with mes, ndp, tq6 |
![]() | Domain d1ia4b_: 1ia4 B: [62110] complexed with mes, ndp, tq6 |
![]() | Domain d1m78a_: 1m78 A: [84855] complexed with clz, ndp |
![]() | Domain d1m78b_: 1m78 B: [84856] complexed with clz, ndp |
![]() | Domain d1m79a_: 1m79 A: [84857] complexed with mes, mq1, ndp |
![]() | Domain d1m79b_: 1m79 B: [84858] complexed with mes, mq1, ndp |
![]() | Domain d1m7aa_: 1m7a A: [84859] complexed with mqu, ndp |
![]() | Domain d1m7ab_: 1m7a B: [84860] complexed with mqu, ndp |
![]() | Domain d3qlra1: 3qlr A:3-192 [184476] Other proteins in same PDB: d3qlra2, d3qlrb2 automated match to d1ai9a_ complexed with gly, gol, ndp, qlr |
![]() | Domain d3qlrb1: 3qlr B:3-192 [184477] Other proteins in same PDB: d3qlra2, d3qlrb2 automated match to d1ai9a_ complexed with gly, gol, ndp, qlr |
![]() | Domain d3qlsa1: 3qls A:3-192 [184478] Other proteins in same PDB: d3qlsa2, d3qlsb2 automated match to d1ai9a_ complexed with 55v, gly, gol, ndp |
![]() | Domain d3qlsb1: 3qls B:3-192 [184479] Other proteins in same PDB: d3qlsa2, d3qlsb2 automated match to d1ai9a_ complexed with 55v, gly, gol, ndp |
![]() | Domain d3qlwa_: 3qlw A: [184480] automated match to d1ai9a_ complexed with n22, ndp |
![]() | Domain d3qlwb_: 3qlw B: [184481] automated match to d1ai9a_ complexed with n22, ndp |
![]() | Domain d4h95a_: 4h95 A: [222440] automated match to d4h96a_ complexed with 06u, ndp |
![]() | Domain d4h95b_: 4h95 B: [222441] automated match to d4h96a_ complexed with 06u, ndp |
![]() | Domain d4h96a_: 4h96 A: [196717] automated match to d1aoea_ complexed with 14q, ndp |
![]() | Domain d4h96b_: 4h96 B: [202386] automated match to d4h96a_ complexed with 14q, ndp |
![]() | Domain d4h97a1: 4h97 A:4-192 [202387] Other proteins in same PDB: d4h97a2, d4h97b2 automated match to d4h97b_ complexed with 53s, gol, ndp |
![]() | Domain d4h97b1: 4h97 B:4-192 [196722] Other proteins in same PDB: d4h97a2, d4h97b2 automated match to d1aoea_ complexed with 53s, gol, ndp |
![]() | Domain d4hoea_: 4hoe A: [237805] automated match to d1aoea_ complexed with 18g, gly, gol, ndp |
![]() | Domain d4hoeb_: 4hoe B: [237807] automated match to d1aoea_ complexed with 18g, gly, gol, ndp |
![]() | Domain d4hofa_: 4hof A: [237808] automated match to d1aoea_ complexed with 18h, gly, gol, ndp |
![]() | Domain d4hofb_: 4hof B: [237809] automated match to d1aoea_ complexed with 18h, gly, gol, ndp |
Timeline for Protein Dihydrofolate reductases, eukaryotic type from c.71.1.1: Dihydrofolate reductases: